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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                              Washington D.C. 20549

                                    FORM 10Q



[ X ]    QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15 (d) OF
         THE SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended:             September 30, 2001
                                 -----------------------------------------------

                                       OR

[    ]   TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 (d) OF
         THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from to Commission file number: 0-22319

                            PATIENT INFOSYSTEMS, INC.
                            -------------------------
             (Exact name of registrant as specified in its charter)

__________Delaware_________________         _________16-1476509______________
          --------                                   ----------              ---
(State or other jurisdiction of             (I.R.S. Employer Identification No.)
incorporation or organization)

                      46 Prince Street, Rochester, NY 14607
                      -------------------------------------
                    (Address of principal executive offices)
                                   (Zip Code)

                                 (716) 242-7200
                                 --------------
              (Registrant's telephone number, including area code)


     Indicate  by check mark  whether the  registrant  (1) has filed all reports
required to be filed by Section 13 or 15 (d) of the  Securities  Exchange Act of
1934  during  the  preceding  12 months  (or for such  shorter  period  that the
registrant was required to file such reports),  and (2) has been subject to such
filing requirements for the last 90 days. Yes [X] No [ ]

     As of November 12, 2001, 10,956,024 common shares were outstanding.

--------------------------------------------------------------------------------




PART I. FINANCIAL INFORMATION
Item 1. Consolidated Financial Statements



PATIENT INFOSYSTEMS, INC.

CONDENSED CONSOLIDATED BALANCE SHEETS
---------------------------------------------------------------------------------------------------------------------------
                                                                                    (unaudited)
ASSETS                                                                           September 30, 2001    December 31, 2000
                                                                                 ------------------    -----------------
CURRENT ASSETS:
                                                                                                          
  Cash and cash equivalents                                                                   $30,731              $28,231
  Accounts receivable                                                                         226,553              411,436
  Prepaid expenses and other current assets                                                    85,067              166,167
                                                                               --------------------------------------------
        Total current assets                                                                  342,351              605,834

PROPERTY AND EQUIPMENT, net                                                                   577,448              827,050

Debt issuance costs (net of accumulated amortization of $875,367 and $664,750)                 17,868              192,750
Intangible assets (net of accumulated amortization of $263,792 and $156,113)                  358,931              466,610
Other assets                                                                                     -                 200,000
                                                                               --------------------------------------------

TOTAL ASSETS                                                                               $1,296,598           $2,292,244
                                                                               ============================================

LIABILITIES AND STOCKHOLDERS' DEFICIT

CURRENT LIABILITIES:
  Accounts payable                                                                           $185,170             $233,545
  Accrued salaries and wages                                                                  254,656              176,158
  Borrowings from directors                                                                 3,302,500            1,171,000
  Line of credit                                                                            2,500,000                 -
  Accrued expenses                                                                            575,131              238,561
  Deferred revenue                                                                            122,027              161,961
                                                                               --------------------------------------------
        Total current liabilities                                                           6,939,484            1,981,225
                                                                               --------------------------------------------

LINE OF CREDIT                                                                                   -               2,500,000

STOCKHOLDERS' DEFICIT:
  Common stock - $.01 par value:  shares authorized:
      20,000,000; issued and outstanding: September 30,
     2001 - 10,956,024; December 31, 2000 - 8,220,202                                         109,560               82,202
  Preferred stock - $.01 par value:  shares authorized: 5,000,000
    Series C, 9% cumulative, convertible
      issued and outstanding - 100,000                                                          1,000                1,000
  Additional paid-in capital                                                               24,377,848           24,016,798
  Accumulated other comprehensive income                                                        1,805                1,805
  Accumulated deficit                                                                    (30,133,099)         (26,290,786)
                                                                               --------------------------------------------
        Total stockholders' deficit                                                       (5,642,886)          (2,188,981)
                                                                               --------------------------------------------

TOTAL LIABILITIES AND STOCKHOLDERS' DEFICIT                                                $1,296,598           $2,292,244
                                                                               ============================================

See notes to unaudited condensed consolidated financial statements.




PATIENT INFOSYSTEMS, INC.

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (UNAUDITED)
-----------------------------------------------------------------------------------------------------------------------

                                                                Three Months Ended             Nine Months Ended
                                                                   September 30,                 September 30,
                                                                2001           2000           2001           2000
                                                                ----           ----           ----           ----
REVENUES
                                                                                          
  Operations Fees                                             $307,212       $385,304       $954,860     $1,517,598
  Development Fees                                              15,900         13,246         72,246         34,446
  Licensing Fees                                                30,500         35,000         84,500         80,826
                                                        ------------------------------------------------------------
       Total revenues                                          353,612        433,550      1,111,606      1,632,870
                                                        ------------------------------------------------------------
COSTS AND EXPENSES
  Cost of sales                                                576,900        982,638      1,897,609      3,354,557
  Sales and marketing                                          200,206        234,942        629,396        920,603
  General and administrative                                   423,765        397,323      1,155,214      1,279,835
  Financing Costs                                                8,934        192,750        558,491        472,000
  Research and development                                      68,091         73,997        163,523        237,196
                                                        ------------------------------------------------------------
        Total costs and expenses                             1,277,896      1,881,650      4,404,233      6,264,191
                                                        ------------------------------------------------------------

OPERATING LOSS                                               (924,283)    (1,448,100)    (3,292,626)    (4,631,321)

INTEREST EXPENSE                                             (107,644)       (58,080)      (293,583)      (121,579)
INVESTMENT LOSS                                              (200,000)          -          (200,000)          -
OTHER INCOME (EXPENSE)                                          10,566        (4,587)         11,397       (21,144)
                                                        ------------------------------------------------------------
NET LOSS                                                   (1,221,361)    (1,510,767)    (3,774,813)    (4,774,044)

CONVERTIBLE PREFERRED STOCK DIVIDENDS                         (22,500)       (22,500)       (67,500)      (595,000)

NET LOSS ATTRIBUTABLE TO
  COMMON STOCKHOLDERS                                    $ (1,243,861)  $ (1,533,267)  $ (3,842,313)  $ (5,369,044)
                                                        ============================================================
NET LOSS PER SHARE - BASIC
   AND DILUTED                                                $ (0.11)       $ (0.19)       $ (0.41)       $ (0.66)
                                                        ============================================================
WEIGHTED AVERAGE COMMON  SHARES                             10,956,024      8,209,040      9,365,194      8,106,779
                                                        ============================================================


See notes to unaudited condensed consolidated financial statements.




PATIENT INFOSYSTEMS, INC.
CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (UNAUDITED)
---------------------------------------------------------------------------------------------------------------------------
                                                                                    Nine Months           Nine Months
                                                                                       Ended                 Ended
                                                                                September 30, 2001    September 30, 2000

OPERATING ACTIVITIES:
                                                                                                   
  Net loss                                                                         $ (3,774,813)         $ (4,774,044)
  Adjustments to reconcile net loss to net cash used in
    operating activities:
      Depreciation and amortization                                                      576,109               896,544
      Investment Loss                                                                    200,000                  -
      (Gain) loss on sale of property                                                      (305)                21,842
      Compensation expense related to issuance of stock and warrants                     352,673                 1,042
      Decrease in accounts receivable, net                                               184,883               242,338
      Decrease in prepaid expenses and other current assets                               81,100                70,741
      Decrease in other assets                                                              -                   44,011
      Decrease in accounts payable                                                      (48,375)             (267,640)
      Increase in accrued salaries and wages                                              78,498                26,959
      Increase in accrued expenses                                                       269,070                36,662
      Decrease in deferred revenue                                                      (39,934)              (60,469)
                                                                                        --------              --------
            Net cash used in operating activities                                    (2,121,094)           (3,762,014)
                                                                                     -----------           -----------
INVESTING ACTIVITIES:
  Property and equipment additions                                                       (8,706)              (17,976)
  Proceeds from the sale of property                                                        800                18,240
                                                                                         -------               ------
          Net cash (used in) provided by investing activities                            (7,906)                  264
                                                                                         -------               ------
FINANCING ACTIVITIES:
  Proceeds from issuance of common and preferred stock, net                                 -               1,025,020
  Borrowing from directors                                                             2,131,500              375,000
  Line of credit borrowings                                                                 -               2,000,000
                                                                                       ---------            ---------
            Net cash provided by financing activities                                  2,131,500            3,400,020
                                                                                      ----------            ---------
NET (DECREASE) INCREASE IN CASH AND CASH  EQUIVALENTS                                      2,500             (361,730)

CASH AND CASH EQUIVALENTS AT
  BEGINNING OF PERIOD                                                                     28,231              489,521
                                                                                         -------              -------
CASH AND CASH EQUIVALENTS AT
  END OF PERIOD                                                                          $30,731             $127,791
                                                                                        ========             ========
Supplemental disclosures of non-cash information
  Dividend delared on Class C Convertible Preferred Stock                               $67,500               $45,000
                                                                                        ========              =======
  Value of beneficial conversion feature on Class C Convertible Preferred Stock
    recognized as a dividend                                                            $  -                 $550,000
                                                                                        ========             ========


See notes to unaudited condensed consolidated financial statements.

PATIENT INFOSYSTEMS, INC.

Notes to Unaudited Condensed  Consolidated  Financial  Statements for the period
ended September 30, 2001

1.   The accompanying  condensed consolidated financial statements for the three
     and nine month periods ended  September 30, 2001 and 2000 are unaudited and
     reflect all adjustments  (consisting only of normal recurring  adjustments)
     which are, in the opinion of management,  necessary for a fair presentation
     of the financial  position and operating  results for the interim  periods.
     These unaudited condensed  consolidated financial statements should be read
     in conjunction with the audited consolidated financial statements and notes
     thereto,  together with  management's  discussion and analysis of financial
     condition  and results of  operations  contained  in the  Company's  Annual
     Report  on  Form  10-K  for the  year  ended  December  31,  2000.  Certain
     reclassifications  of  2000  amounts  have  been  made to  conform  to 2001
     presentations.  The  results of  operations  for the three and nine  months
     ended September 30, 2001 are not necessarily  indicative of the results for
     the entire year ending December 31, 2001.

2.   On March 28, 2001, the Company  entered into an Amended and Restated Credit
     Agreement with Wells Fargo Bank Iowa,  N.A., which extended the term of the
     Company's  credit facility to March 31, 2002 under  substantially  the same
     terms.  Dr.  Schaffer  and Mr.  Pappajohn,  two  directors  of the Company,
     guaranteed this  extension.  In  consideration  for their  guarantees,  the
     Company  re-priced 625,000 warrants  previously  granted in connection with
     prior guarantees to $0.05 per share, effective April 1, 2001. The net value
     of these  re-priced  warrants is $35,735.  The Company is  amortizing  this
     amount as debt issuance cost using a straight-line method over the 12-month
     period  ending March 31, 2002.  The  estimated  fair value of the re-priced
     warrants was determined using the Black Scholes method.

3.   The Company  borrowed  $2,131,500  for working  capital from Mr.  Pappajohn
     during the nine month period ended  September 30, 2001.  From September 30,
     2001 through October 31, 2001, the Company borrowed an additional  $265,000
     from Mr.  Pappajohn.  Through  October 31, 2001, a total of $3,567,500  has
     been borrowed from Mr. Pappajohn and Dr. Schaffer,  all of which is secured
     by the assets of the Company. There can be no assurances that Mr. Pappajohn
     will continue to make funds available to the Company. If such funds are not
     available, the Company will cease operations.

     On June 6,  2001,  the  Company  issued  a total  of  2,319,156  shares  of
     unregistered Common Stock to Mr. Pappajohn and Dr. Schaffer as compensation
     for their  continued  financial  support of the Company.  Based upon recent
     trading of the Company's Common Stock at the time of issuance,  the Company
     assigned a fair  market  value of $0.15 per share or a total of $347,873 to
     these unregistered  shares and realized this amount as an operating expense
     in June of 2001.

4.   For the  three-month  periods  ended  September  30,  2001  and  2000,  the
     calculations  for the basic and diluted loss per share were based upon loss
     attributable   to  common   stockholders   of  $1,243,861  and  $1,533,267,
     respectively,  and a weighted average number of common shares of 10,956,024
     and 8,209,040 respectively.

     For  the  nine-month  periods  ended  September  30,  2001  and  2000,  the
     calculations  for the basic and diluted loss per share were based upon loss
     attributable   to  common   stockholders   of  $3,842,313  and  $5,369,044,
     respectively,  and a weighted  average number of common shares of 9,365,194
     and 8,106,779 respectively.

     Options and warrants to purchase  shares of Common  Stock were  outstanding
     but not included in the computation of diluted loss per share for the three
     and nine month periods ended September 30, 2001 and 2000 because the effect
     would have been antidilutive due to the net loss in those periods.

5.   The accompanying unaudited condensed consolidated financial statements have
     been prepared on a going concern basis,  which contemplates the realization
     of assets and the  satisfaction  of  liabilities  in the  normal  course of
     business.  As shown in the accompanying  unaudited  condensed  consolidated
     financial statements,  the Company incurred a net loss of for the three and
     nine month periods ended  September 30, 2001 of $1,221,361 and  $3,774,813,
     respectively,  and had an  accumulated  deficit of $30,133,099 at September
     30, 2001. These factors,  among others,  may indicate that the Company will
     be unable to continue as a going concern for a reasonable period of time.

     The unaudited condensed  consolidated  financial  statements do not include
     any adjustments relating to the recoverability of assets and classification
     of  liabilities  that might be  necessary  should the  Company be unable to
     continue as a going concern.  The Company's  ability to continue as a going
     concern is dependant upon its ability to generate  sufficient  cash flow to
     meet its  obligations.  Management  is currently  assessing  the  Company's
     operating   structure  for  the  purpose  of  reducing  ongoing   expenses,
     increasing  sources of revenue and is  negotiating  the terms of additional
     debt or equity financing.

6.   The Company held an  investment  of Common Stock in a private  company (the
     "Investment")  that was recorded at its  historical  cost of $200,000.  The
     Company  has  been  made  aware  that the  private  company  to  which  the
     Investment  relates intends to cease operations.  Accordingly,  the Company
     considers  the  Investment  to be other than  temporarily  impaired and has
     written  off the  Investment's  entire  carrying  value  of  $200,000  as a
     non-operating expense as of September 30, 2001.

7.   On June 29, 2001,  Statement of Financial  Accounting  Standards (SFAS) No.
     141,  "Business  Combinations"  was  issued  by  the  Financial  Accounting
     Standards  Board (FASB).  SFAS No. 141 requires that the purchase method of
     accounting be used for all business  combinations  initiated after June 30,
     2001.  Goodwill  and certain  intangible  assets will remain on the balance
     sheet and not be amortized.  On an annual basis, and when there is a reason
     to suspect that their values have diminished or impaired, these assets must
     be tested for impairment,  and write-downs may be necessary. The Company is
     required  to  implement  SFAS  No.  141 on  July  1,  2001  and it has  not
     determined  the  impact,  if any,  that  this  statement  will  have on its
     consolidated financial position or the results of operations.

     On June 29, 2001, SFAS No. 142,  "Goodwill and Other Intangible Assets" was
     issued by the FASB.  SFAS No. 142 changes the  accounting for goodwill from
     an  amortization  method to an  impairment-only  approach.  Amortization of
     goodwill,  including goodwill recorded in past business combinations,  will
     cease upon adoption of this statement. The Company is required to implement
     SFAS No. 142 by January 1, 2002 and has not determined the impact,  if any,
     that this statement  will have on its  consolidated  financial  position or
     results of operations.






Item 2. Management's  Discussion and Analysis of Financial Condition and Results
     of Operations.

     Management's  discussion  and analysis  provides a review of the  Company's
operating  results for the three and nine month periods ended September 30, 2001
and 2000 and its financial  condition at September  30, 2001.  The focus of this
review is on the underlying  business reasons for significant changes and trends
affecting the revenues,  net losses and financial condition of the Company. This
review should be read in conjunction with the accompanying  unaudited  condensed
consolidated financial statements.

     In an effort to give investors a well-rounded view of the Company's current
condition and future opportunities,  this Quarterly Report on Form 10-Q includes
forecasts by the  Company's  management  about future  performance  and results.
Because they are forward-looking,  these forecasts involve uncertainties.  These
uncertainties  include the  Company's  ability to continue its  operations  as a
result of, among other things,  continuing losses,  working capital  shortfalls,
uncertainties with respect to sources of capital,  risks of market acceptance of
or preference for the Company's systems and services,  competitive  forces,  the
impact of  changes in government  regulations,  general  economic factors in the
healthcare  industry and other factors  discussed in the Company's  filings with
the Securities and Exchange Commission, including the Company's Annual Report on
Form 10-K for the year ended December 31, 2000.

     Results of Operations

     Revenues

     Revenues  consist  of  revenues  from  operations,   development  fees  and
licensing fees. Revenues decreased from $433,550 and $1,632,870 during the three
and nine month periods ended September 30, 2000,  respectively,  to $353,612 and
$1,111,606  during the three and nine month periods ended September 30, 2001, or
18% and 32% respectively.



                                                        Three Months Ended                     Nine Months Ended
                                                           September 30,                         September 30,
Revenues                                               2001             2000                 2001             2000
--------                                               ----             ----                 ----             ----
Operations Fees
                                                                                              
  Disease Management and Compliance                $ 108,184        $ 164,935            $ 363,541        $ 493,559
  Surveys                                             42,244           54,089              128,424          315,976
  Demand Management                                  138,784          146,603              408,895          619,859
  Other                                               18,000           19,677               54,000           88,204
                                            ----------------------------------    ----------------------------------
Total Operations Fees                                307,212          385,304              954,860        1,517,598
Development Fees                                      15,900           13,246               72,246           34,446
Licensing Fees                                        30,500           35,000               84,500           80,826
                                            ----------------------------------    ----------------------------------

Total Revenues                                     $ 353,612        $ 433,550          $ 1,111,606      $ 1,632,870
                                            ----------------------------------    ----------------------------------


     Operations  revenues are generated as the Company provides  services to its
customers. Operations revenues decreased from $385,304 and $1,517,598 during the
three and nine month periods ended September 30, 2000, respectively, to $307,212
and $954,860  during the three and nine month periods ended  September 30, 2001,
respectively.  Operations  revenues continue to be the primary source of revenue
for the Company.  Operations  revenues  declined  because of the  termination of
agreements  for the  conduct  of  surveys  as a result of the  elimination  of a
Medicare product by two of the Company's primary customers and the completion of
several compliance programs that have not been fully replaced by new programs.

     The Company's revenue has continued to decline. The Company has established
relationships  with  several  new  customers  and entered  into joint  marketing
relationships with several of its strategic partners.  While revenues from these
relationships  have been realized and are expected to grow, no assurances can be
given that such revenues will be material to the Company's results of operations
and  financial  condition.   The  Company  has  identified  other  possible  new
customers,  but there can be no assurance that such  prospects  will  contribute
revenue in the near term, if at all.

     Development fee revenues increased from $13,246 to $15,900 and from $34,446
to $72,246 for the three and nine month  periods  ended  September  30, 2000 and
2001,  respectively.  This increase was due to increased focus on development of
new programs  and  enhancement  of existing  programs.  Development  fee revenue
represents  the  amounts  that  the  Company   charges  its  customers  for  the
development  or  customization  programs  for  which  it  anticipates  on  going
operations revenues. The Company has entered into new development agreements but
anticipates  that revenue from program  development  will remain constant in the
future.

     License fee revenues  recognized  from the Case  Management  Support System
decreased to $30,500 from $35,000 for the  three-month  periods ended  September
30,  2001 and 2000, respectively.  License  Revenue  increased  to $84,500  from
$80,826  for  the  nine  month  periods  ended   September  30,  2001  and  2000
respectively.  These changes are due to the  negotiated  schedule of fees in the
ongoing contracts. The Company has not entered into any new licensing agreements
for its Case  Management  Support  System and the revenue for the current period
reflects ongoing revenue from the existing agreements.

     Costs and Expenses

     Cost of sales include salaries and related  benefits,  services provided by
third  parties,  and  other  expenses  associated  with the  implementation  and
delivery of the  Company's  standard  and  customized  population,  demand,  and
disease management  programs.  Cost of sales for the three and nine months ended
September  30, 2001 was $576,900 and  $1,897,609,  respectively,  as compared to
$982,638 and $3,354,557 (a decrease of 41% and 43%,  respectively) for the three
and nine month  periods ended  September  30, 2000.  The decrease in these costs
primarily  reflects a response to the decreased  level of population and disease
management  operational  activities.  The Company's gross margin continues to be
negative.  The Company  anticipates  that  revenue must  substantially  increase
before it will  recognize  economies of scale.  No  assurance  can be given that
revenues will increase or that, if they do, they will exceed costs and expenses.

     Sales  and  marketing  expenses  consist  primarily  of  salaries,  related
benefits,  travel costs,  sales materials and other marketing  related expenses.
Sales  and  marketing  expenses  for the  three  and nine  month  periods  ended
September  30, 2001 were  $200,206  an  $629,396,  respectively,  as compared to
$234,942 and $920,603,  respectively, for the three and nine month periods ended
September 30, 2000.  Spending in this area has decreased due to the  termination
of staff and renegotiation of certain  compensation  plans. The Company does not
have the resources to expand its sales and  marketing  staff but expects it will
be required to invest in the sales and marketing process, and that such expenses
related to sales and marketing may increase in future periods.

     General  and  administrative   expenses  include  the  costs  of  corporate
operations,  finance and accounting, human resources and other general operating
expenses of the Company.  General and administrative  expenses for the three and
nine month  periods  ended  September  30, 2001 were  $423,765  and  $1,155,214,
respectively,  as compared to $397,323  and  $1,279,835,  respectively,  for the
three and nine month periods ended September 30, 2000. These  expenditures  have
been  incurred to maintain  the  corporate  infrastructure  necessary to support
anticipated program operations.  The change in these costs is primarily a result
of reductions in staff and closing of  facilities  in  Pennsylvania  and Canada,
offset by increases in certain other expenses.  The Company expects that general
and administrative expenses will remain relatively constant in future periods.

     Financing costs consist of expenses incurred to obtain  sufficient  working
capital to continue  operations.  These  expense  have  primarily  consisted  of
compensation  cost for shares of the Company's  Common Stock as well as warrants
to  purchase  the  Company's  Common  Stock.  Financing  costs  were  $8,934 and
$558,491, respectively, for the three and nine month periods ended September 30,
2001 as compared to $192,750 and $472,000,  respectively, for the three and nine
month periods ended September 30, 2000. A decrease in financing costs during the
most recent 3 month period was seen because no new equity was issued during that
period.  The increase in financing  costs over the nine month period is a result
of the  Company's  continued  dependence  on debt  to  obtain  working  capital.
Financing  costs are expected to remain  relatively  constant until such time as
the Company can reduce its dependence on debt to fund its operations.

     Research and development expenses consist primarily of salaries and related
benefits and  administrative  costs  associated  with the development of certain
components of the Company's integrated  information capture and delivery system,
as well as development of the Company's standardized disease management programs
and the Company's Internet based technology  products.  Research and development
expenses for the three and nine months ended September 30, 2001 were $68,091 and
$163,523,  respectively, as compared to $73,997 and $237,196,  respectively, for
the same periods of 2000.

     The Company  recorded an investment  loss of $200,000  during the three and
nine month periods ended  September  30,2001.  The Company held an investment of
Common Stock in a private  company (the  "Investment")  that was recorded at its
historical  cost of  $200,000.  The Company has been made aware that the private
company  to  which  the  Investment   relates   intends  to  cease   operations.
Accordingly,  the Company  considers the Investment to be other than temporarily
impaired and has written off the Investment's  entire carrying value of $200,000
as a non-operating expense as of September 30, 2001.

     The  Company   recorded   interest   expenses  of  $107,644  and  $293,583,
respectively,  for the three and nine month periods ended  September 30, 2001 as
compared to $58,080  and  $121,579,  respectively,  for the three and nine month
periods ended September 30, 2000.  These expenses are related the Company's debt
and are expected to increase  steadily until the Company  becomes less dependent
on debt to fund its operations.

     The Company recorded other income of $10,566 and $11,397, respectively, for
the three and nine  month  periods  ended  September  30,  2001 as  compared  to
expenses  $4,587  and  $21,144,  respectively,  for the  same  periods  of 2000,
principally  due to  receipt  of a state tax  refund  and to the sale of certain
assets.

     The Company had a net loss  attributable to the common  shareholders  after
preferred stock dividends, of $1,243,861 and $3,842,313,  respectively,  for the
three and nine months ended  September  30, 2001 as compared to  $1,533,267  and
$5,369,044,  respectively,  for the three and nine month periods ended September
30, 2000  respectively.  This represents a net loss per common share of $.41 for
the nine month period  ended  September  30, 2001,  as compared to a net loss of
$.66 per common share in the same period of 2000. The preferred  stock dividends
in 2000 include a beneficial conversion feature for the 100,000 shares of Series
C Stock of $550,000.

     Liquidity and Capital Resources

     At  September  30,  2001 the  Company  had a  working  capital  deficit  of
$6,597,133  as compared to  $1,375,391  at December 31, 2000.  The September 30,
2001 amounts reflect the effects of the Company's  continuing  losses as well as
increased  borrowings,  $2,500,000  of which was  considered  to be a  long-term
liability  at December  31, 2000 but is  classified  as a current  liability  at
September 30, 2001.  Since its inception,  the Company has primarily  funded its
operations,  working  capital  needs and capital  expenditures  from the sale of
equity securities and borrowings from directors and external sources.

     On March 31,  2000,  the Company  completed a private  placement of 100,000
shares  of newly  issued  Series C 9%  Cumulative  Convertible  Preferred  Stock
("Series  C"),  raising  $1,000,000  in  total  proceeds.  These  shares  can be
converted  into Common Stock at a rate of 8 shares of Common Stock to 1 share of
Series C Preferred Stock.  Each Series C share has voting rights equivalent to 8
shares of Common Stock  (800,000  shares).  The proceeds from this issuance were
used to support the Company's operations. The fair market value of the Company's
Common  Stock at the time of  issuance  of Series C Stock was $1.9375 per share.
The Series C Preferred  Stock is convertible at a price equal to $1.25 per share
of Common Stock resulting in a discount,  or beneficial  conversion  feature, of
$0.6875  per  share.  The total  amount of this  beneficial  conversion  feature
($550,000) is deemed to be the  equivalent of a preferred  stock  dividend.  The
Company  recorded  the deemed  dividend at the date of  issuance  by  increasing
accumulated  deficit and increasing  additional  paid-in  capital.  Accordingly,
there was no net effect on total stockholders' equity.

     On March 28, 2001, the Company  entered into an Amended and Restated Credit
Agreement  with Wells  Fargo Bank Iowa,  N.A.,  which  extended  the term of the
Company's credit facility to March 31, 2002 under  substantially the same terms.
Dr. Schaffer and Mr.  Pappajohn,  two directors of the Company,  guaranteed this
extension. In consideration for their guarantees,  the Company re-priced 625,000
warrants  previously  granted in connection  with prior  guarantees to $0.05 per
share,  effective April 1, 2001. The Company assigned a fair value of $35,735 to
the warrants and intends to fully  amortize this deferred  financing  cost using
the  straight-line  method over the 12-month  period ending March 31, 2002.  The
estimated fair value of the re-priced  warrants was determined as the difference
between (i) the fair market value of the  original  warrants as of April 1, 2001
using the Black  Scholes  method and (ii) the fair market value of the re-priced
warrants as of April 1, 2001.

     The Company  borrowed  $2,131,500  for working  capital from Mr.  Pappajohn
during the nine month period ended  September 30, 2001.  From September 30, 2001
through October 31, 2001, the Company  borrowed an additional  $265,000 from Mr.
Pappajohn.  Through  October 31, 2001, a total of  $3,567,500  has been borrowed
from Mr.  Pappajohn and Dr.  Schaffer,  all of which is secured by the assets of
the Company. There can be no assurances that Mr. Pappajohn will continue to make
funds  available to the Company.  If such funds are not  available,  the Company
will cease operations.

     The Company held an  investment  of Common Stock in a private  company (the
"Investment") that was recorded at its historical cost of $200,000.  The Company
has been made aware that the  private  company to which the  Investment  relates
intends to cease operations.  Accordingly,  the Company considers the Investment
to be other than  temporarily  impaired  and has  written  off the  Investment's
entire carrying value of $200,000 as a non-operating expense as of September 30,
2001.

     The  Company has  expended  substantial  amounts to expand its  operational
capabilities  and  strengthen  its  infrastructure,  which at the same  time has
increased its  administrative  and technical  costs. In addition,  the Company's
cash has been  steadily  depleted as a result of operating  losses.  The Company
anticipates  that its losses will  continue  and,  except for the loans from Mr.
Pappajohn,  the Company has no available capital.  Accordingly,  the Company has
been  required  to seek  capital to  maintain  its  operations.  Any  additional
financing,  which includes the issuance of additional securities of the Company,
may be dilutive to the Company's existing stockholders. If the Company is unable
to identify additional capital, it will be required to cease operations.

     On June  7,  2001,  the  Company  issued  a press  release  concerning  the
execution of a definitive  agreement to acquire  substantially all the assets of
Health Data  Solutions of  Brownsburg,  Indiana and its affiliate  American Care
Source of Dallas, Texas.

     On September 28, 2001, the Company issued a press release  announcing  that
the agreement to acquire  substantially  all the assets of Health Data Solutions
and American Care Source was terminated.

     Inflation

     Inflation did not have a significant  impact on the Company's  costs during
the three and nine month periods ended  September 30, 2001 and 2000. The Company
continues  to monitor the impact of  inflation  in order to minimize its effects
through pricing strategies, productivity improvements and cost reductions.

     Forward Looking Statements

     When used in this and in future  filings by the Company with the Securities
and Exchange Commission,  in the Company's press releases and in oral statements
made with the approval of an authorized  executive  officer of the Company,  the
words or phrases "will likely result,"  "expects," "plans," "will continue," "is
anticipated,"  "estimated,"  "project,"  or  "outlook"  or  similar  expressions
(including  confirmations by an authorized  executive  officer of the Company of
any such  expressions  made by a third party with  respect to the  Company)  are
intended  to  identify  "forward-looking  statements"  within the meaning of the
Private Securities  Litigation Reform Act of 1995. The Company wishes to caution
readers not to place undue reliance on any such forward-looking statements, each
of which speak only as of the date made.  Such statements are subject to certain
risks and  uncertainties  that could cause actual  results to differ  materially
from  historical  earnings and those presently  anticipated or projected.  These
uncertainties  include the  Company's  ability to continue its  operations  as a
result of, among other things,  continuing losses,  working capital short falls,
uncertainties with respect to sources of capital,  risks of market acceptance of
or preference for the Company's systems and services,  competitive  forces,  the
impact of, changes in government  regulations,  general  economic factors in the
healthcare  industry and other factors  discussed in the Company's  filings with
the Securities and Exchange Commission  including the Company's Annual Report on
Form 10-K for the year ended December 31, 2000. The Company has no obligation to
publicly  release  the  result  of  any  revisions,  which  may be  made  to any
forward-looking  statements to reflect  anticipated or  unanticipated  events or
circumstances occurring after the date of such statements.

     New Accounting Pronouncements

     During  the  first  quarter  of 2001,  the  Company  adopted  Statement  of
Financial  Accounting  Standards  ("SFAS") No. 133,  Accounting  for  Derivative
Instruments  and  Hedging  Activities.   The  Company  has  not  identified  any
derivatives  that  meet  criteria  for a  derivative  instrument  and  does  not
participate in any hedging  activities.  As a result,  management of the Company
concluded  that  there  was no  material  effect on the  Company's  consolidated
financial  position,  results of  operations  or cash flows  resulting  from the
adoption of SFAS No. 133 in 2001.

     In September 2000, the Financial Accounting Standards Board issued SFAS No.
140,   "Accounting   for  Transfers  and  Servicing  of  Financial   Assets  and
Extinguishment of Liabilities,"  which supercedes SFAS No. 125,  "Accounting for
Transfers and Servicing of Financial Assets and Extinguishments of Liabilities."
This standard is effective for transfers  occurring  after March 31, 2001,  with
certain disclosure requirements effective for the year ending December 31, 2000.
Management of the Company has concluded that there was no material effect on the
Company's consolidated  financial position,  results of operations or cash flows
resulting from the adoption of SFAS No. 140 at September 30, 2001.

     On June 29, 2001,  Statement of Financial  Accounting  Standards (SFAS) No.
141, "Business  Combinations" was issued by the Financial  Accounting  Standards
Board (FASB).  SFAS No. 141 requires  that the purchase  method of accounting be
used for all business  combinations  initiated after June 30, 2001. Goodwill and
certain intangible assets will remain on the balance sheet and not be amortized.
On an annual basis, and when there is a reason to suspect that their values have
diminished  or  impaired,  these  assets  must be  tested  for  impairment,  and
write-downs may be necessary.  The Company is required to implement SFAS No. 141
on  July 1,  2001  and it has not  determined  the  impact,  if any,  that  this
statement  will have on its  consolidated  financial  position or the results of
operations.

     On June 29, 2001, SFAS No. 142,  "Goodwill and Other Intangible Assets" was
issued by the FASB.  SFAS No. 142 changes the  accounting  for goodwill  from an
amortization  method to an impairment-only  approach.  Amortization of goodwill,
including  goodwill  recorded  in past  business  combinations,  will cease upon
adoption of this statement. The Company is required to implement SFAS No. 142 by
January 1, 2002 and has not determined  the impact,  if any, that this statement
will have on its consolidated financial position or results of operations.

Item 3.  Quantitative and Qualitative Disclosures About Market Risk

     The Company is exposed to changes in interest  rates  primarily in its cash
transactions.  The interest paid on the Company's  outstanding line of credit is
based upon the prime rate.  The Company has the option of reducing  its interest
expenses by rolling the outstanding line of credit balance into notes that carry
a rate equal to LIBOR plus 1.75%.

     In relation to the operations of Patient Infosystems  Canada,  fluctuations
of foreign  currency can impact the Company's net  operating  results.  However,
management  believes that due to the relative size of its  operations in Canada,
such impact would not be significant to the consolidated  financial  statements.
The  Company  currently  has no  significant  investments  in  foreign  currency
instruments.

     The  balances  the Company has in cash or cash  equivalents  are  generally
available without legal restrictions to fund ordinary business  operations.  The
Company  regularly  invests excess operating cash in certificates of deposit and
U.S.  government bonds and other bonds that are subject to changes in short-term
interest rates.  Accordingly,  the Company believes that the market risk arising
from its holding of these financial  instruments is minimal. The Company did not
make any purchases of available-for-sale  securities in the three and nine month
periods ended September 30, 2000 and 2001.

PART II - OTHER INFORMATION

Item 2.  Changes in Securities and Use of Proceeds

     Borrowing from directors

     The Company  borrowed  $2,131,500  for working  capital from Mr.  Pappajohn
during the nine month period ended  September 30, 2001.  From September 30, 2001
through October 31, 2001, the Company  borrowed an additional  $265,000 from Mr.
Pappajohn.  Through  October 31, 2001, a total of  $3,567,500  has been borrowed
from Mr.  Pappajohn and Dr.  Schaffer,  all of which is secured by the assets of
the Company. There can be no assurances that Mr. Pappajohn will continue to make
funds  available to the Company.  If such funds are not  available,  the Company
will cease operations.


Item 6.  Exhibits and Reports on Form 8-K


     On June  7,  2001,  the  Company  issued  a press  release  concerning  the
execution of a definitive  agreement to acquire  substantially all the assets of
Health Data  Solutions of  Brownsburg,  Indiana and its affiliate  American Care
Source of Dallas, Texas.

     On September 28, 2001, the Company issued a press release  announcing  that
the agreement to acquire  substantially  all the assets of Health Data Solutions
and American Care Source was terminated.



Exhibits:
--------

(a)  (11)  Statements of Computation of Per Share Earnings

(b)  Incorporated  herein  by  reference  in  entirety,  is a copy of the  press
     release filed with the Commission by the Company on June 7, 2001 as Exhibit
     99.1 of Form 8-K.







SIGNATURES

Pursuant  to the  requirements  of the  Securities  Exchange  Act of  1934,  the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned thereunto duly authorized.

Dated:  November 12, 2001



                                              PATIENT INFOSYSTEMS, INC.
                                              (Registrant)


Date: November 12, 2001                      /s/Roger L. Chaufournier
      ------------------------------         -----------------------------------
                                             Roger L. Chaufournier
                                             Director, President and
                                             Chief Executive Officer

Date: November 12, 2001                      /s/ Kent A. Tapper
      ------------------------------         -----------------------------------
                                             Kent A. Tapper
                                             Principal Accounting Officer






Exhibit 11. Statement of Computation of Per Share Earnings



PATIENT INFOSYSTEMS, INC.

                                                       Three Months Ended                     Nine Months Ended
                                                          September 30,                          September 30,
                                                      2001             2000                  2001                2000
                                                ------------     ------------         -------------       -------------
                                                                                              
Net loss                                        $(1,221,361)     $(1,510,767)         $ (3,774,813)       $ (4,774,044)
Convertible preferred Stock dividends               (22,500)         (22,500)              (67,500)           (595,000)
                                                    --------         --------              --------           ---------
Net loss attributable to
     Common Stockholders                        $(1,243,861)     $(1,533,267)         $ (3,842,313)       $ (5,369,044)
                                                ------------     ------------         -------------       -------------
Weighted average common shares                   10,956,024        8,209,040             9,365,194           8,106,779
                                                 -----------       ----------            ----------          ---------
Net loss per share - Basic and diluted            $   (0.11)       $   (0.19)           $    (0.41)         $    (0.66)
                                                  ==========       ==========           ===========         ===========