SCHEDULE 14A
                                 (Rule 14a-101)
                     INFORMATION REQUIRED IN PROXY STATEMENT
                            SCHEDULE 14A INFORMATION
Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

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                            PATIENT INFOSYSTEMS, INC.
                (Name of Registrant as Specified in Its Charter)


    (Name of Person(s) Filing Proxy Statement, if Other Than the Registrant)


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     Statement No.: Schedule 14A
(3)    Filing Party: Patient Infosystems, Inc. (4) Date Filed: May 15, 2003
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     This supplement  ("Supplement") updates and supplements certain information
provided in the Proxy Statement  ("Proxy  Statement") for the Special Meeting of
Stockholders  which was  originally  scheduled for December 9, 2003 and has been
adjourned until December 31, 2003. At the Special Meeting, our stockholders will
be asked to consider,  among other things, a proposal to approve an amendment to
our  Certificate of  Incorporation  to increase our authorized  capital stock so
that we may complete our acquisition ("Acquisition") of substantially all of the
assets of American CareSource Corporation ("ACS"). Stockholders should carefully
review  this  Supplement  and  the  Proxy  Statement.  The  information  in this
Supplement replaces any inconsistent information in the Proxy Statement.

     You can vote your  shares  by  completing  and  returning  the  proxy  card
included with your Proxy Statement.  You can revoke a proxy at any time prior to
its exercise at the adjourned  Special Meeting by following the  instructions in
the Proxy Statement.

Recent Developments

     ACS has received  written  notification  of the  termination of contractual
relations from Pinnacol Assurance,  which is the largest volume provider to ACS.
The termination of this contract will result in a significant  reduction in ACS'
revenues.  ACS' revenues from Pinnacol Assurance was as follows during the years
ended December 31, 2001 and 2002, respectively,  and during the six months ended
June 30, 2003:



            Year Ended                         Year Ended                Six Months Ended
         December 31, 2001                 December 31, 2002              June 30, 2003
----------------  -------------    -------------  -------------   ------------- -------------
                  Percentage of                   Percentage of                 Percentage of
    Amount        Total Revenue       Amount      Total Revenue      Amount     Total Revenue
----------------  -------------    -------------  -------------   ------------- -------------
                                                                  
   $1,163,041          45.7%         $2,786,409        28.9%       $1,936,799       40.5%


ACS has a limited number of customers,  a few of which account for a substantial
portion of its business.  During the last six months, ACS has received notice of
the  termination of contracts from  customers  representing  in excess of 56% of
ACS' revenues during the six months ended June 30, 2003.

     During the last six months,  ACS has received  written  notification of the
termination  of  contractual  relations  from Pinnacol  Assurance and two of its
other customers  which in the aggregate  accounted for over 51% of ACS' revenues
during the fiscal year ended  December  31, 2002 and  accounted  for over 56% of
ACS'  revenues  during the six months ended June 30, 2003.  The  termination  of
these  contracts  will  result  in a  significant  reduction  of ACS'  revenues.
Although a variety of reasons may be provided for the termination of each of the
customer  agreements,  the  termination of such an extensive  amount of customer
business may reflect a substantial  level of customer  dissatisfaction  with the
services  provided by ACS.  Although  Patient  Infosystems  believes that it can
provide  assistance to ACS and that as a combined  company,  ACS will be able to
provide better services,  no assurance can be given that more customers will not
terminate their relationships with ACS following the closing of the Acquisition.
In addition,  ACS generally  does not have  long-term  contracts  with its other
customers.  Significant  declines in the level of use of ACS  services by one or
more of its remaining  customers  could have a material  adverse  effect on ACS'
business  and  results of  operations.  Additionally,  an adverse  change in the
financial condition of any of these customers,  including an adverse change as a
result of a change in governmental or private reimbursement programs, could have
a material adverse effect on its business.

Decrease in Number of Shares to be Issued to ACS

     As consideration  for  substantially  all of ACS' assets,  we had agreed to
issue  18,000,000  shares of our common  stock to ACS  (1,500,000  shares  after
giving effect to the 1 for 12 reverse stock split which is also discussed in the
Proxy Statement).  As a result of, among other things,  the recent  developments
disclosed  above,  we have  agreed  with ACS that we will issue only  13,200,000
shares of our common stock (1,100,000 shares after giving effect to the 1 for 12
reverse stock split) to ACS upon closing of the Acquisition.  To the extent that
fewer shares of our common stock will be issued,  there will be a  corresponding
decrease in total stockholders' equity. In reviewing the information provided in
the Proxy Statement,  stockholders should consider the decrease in consideration
provided to ACS and the corresponding reduction in pro forma total stockholders'
equity  from  $1,919,014  to  $1,247,014  as a result  of the  reduction  in the
purchase consideration.