Securities and Exchange Commission
                              Washington, DC 20549

                                    Form 8-K

                                 CURRENT REPORT

                     PURSUANT TO SECTION 13 OR 15(d) OF THE

                         SECURITIES EXCHANGE ACT OF 1934



Date of Report (Date of earliest event reported)  April 8, 2004


                            PATIENT INFOSYSTEMS, INC.
             (Exact Name of Registrant as Specified in its Charter)


             Delaware              0-22319                  16-1476509
(State or Other Jurisdiction   (Commission File Number)  (IRS Employer
        of Incorporation)                                Identification No.)


46 Prince Street, Rochester, New York                    14607
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(Address of Principal Executive Offices)                 (Zip Code)

Registrant's telephone number, including area code  (585) 242-7200

          (Former Name or Former Address, if Changed Since Last Report)


ITEM 9.  REGULATION FD DISCLOSURE.

     Attached  hereto as Exhibit 99.1 is a copy of a Press Release issued by the
registrant on April 8, 2004.



                                   SIGNATURES

     Pursuant to the  requirements  of the Securities  Exchange Act of 1934, the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.

                                              PATIENT INFOSYSTEMS, INC.

Date:  April 8, 2004                        By: /s/Roger L. Chaufournier
                                                 ------------------------
                                                 Roger L. Chaufournier
                                                 Chief Executive Officer


                                  EXHIBIT INDEX


Exhibit 99.1 Press release issued on April 8, 2004.