Securities and Exchange Commission
                              Washington, DC 20549

                                    Form 8-K

                                 CURRENT REPORT

                     PURSUANT TO SECTION 13 OR 15(d) OF THE

                         SECURITIES EXCHANGE ACT OF 1934



Date of Report (Date of earliest event reported)  June 18, 2004
                                                 --------------


                            PATIENT INFOSYSTEMS, INC.
             (Exact Name of Registrant as Specified in its Charter)


         Delaware                      0-22319                16-1476509
(State or Other Jurisdiction   (Commission File Number)     (IRS Employer
 of Incorporation)                                        Identification No.)



46 Prince Street, Rochester, New York                     14607
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(Address of Principal Executive Offices)                  (Zip Code)

Registrant's telephone number, including area code   (585) 242-7200
                                                     --------------



          (Former Name or Former Address, if Changed Since Last Report)




ITEM 7. FINANCIAL STATEMENTS, PRO FORMA FINANCIAL INFORMATION AND EXHIBITS.

     See Exhibit Index.

ITEM 9. REGULATION FD DISCLOSURE.

     On June 18, 2004,  the  registrant  issued a press  release  regarding  the
closing  of a private  placement  of shares of its common  stock.  A copy of the
press release is attached as Exhibit 99.1.




                                   SIGNATURES

     Pursuant to the  requirements  of the Securities  Exchange Act of 1934, the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.

                                             PATIENT INFOSYSTEMS, INC.

Date:  June 18, 2004                         By: /s/ Roger L. Chaufournier
                                                 -------------------------
                                                    Roger L. Chaufournier
                                                    Chief Executive Officer







                                  EXHIBIT INDEX


Exhibit 99.1     Press Release dated June 18, 2004 announcing closing of private
                 placement