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                       Securities and Exchange Commission
                              Washington, DC 20549

                                    Form 8-K

                                 CURRENT REPORT

                     PURSUANT TO SECTION 13 OR 15(d) OF THE

                         SECURITIES EXCHANGE ACT OF 1934



       Date of Report (Date of earliest event reported) September 24, 2004


                            PATIENT INFOSYSTEMS, INC.
             (Exact Name of Registrant as Specified in its Charter)

            Delaware                     0-22319               16-1476509
(State or Other Jurisdiction of  (Commission File Number)    (IRS Employer
         Incorporation)                                    Identification No.)

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 46 Prince Street, Rochester, New York               14607
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(Address of Principal Executive Offices)           (Zip Code)
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Registrant's telephone number, including area code:  (585) 242-7200

          (Former Name or Former Address, if Changed Since Last Report)

     Check the  appropriate  box below if the Form 8-K  filing  is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

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     Written  communications  pursuant to Rule 425 under the  Securities Act (17
     CFR 230.425)
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     Soliciting  material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
     240.14a-12)

     Pre-commencement   communications  pursuant  to  Rule  14d-2(b)  under  the
     Exchange Act (17 CFR 240.14d-2(b))

     Pre-commencement   communications  pursuant  to  Rule  13e-4(c)  under  the
     Exchange Act (17 CFR 240.13e-4(c))


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ITEM 9.01  Financial Statements and Exhibits

(c)      Exhibits

         Exhibit No.                Description

          99.1     Press Release issued by the Registrant on September 24, 2004






                                   SIGNATURES

     Pursuant to the  requirements  of the Securities  Exchange Act of 1934, the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.

                                             PATIENT INFOSYSTEMS, INC.

Date:  September 24, 2004             By:       /s/Kent A. Tapper
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                                             Kent A. Tapper
                                             Sr. Vice President
                                             principal accounting officer



                                  EXHIBIT INDEX

Exhibit 99.1              Press release issued on September 24, 2004.