Edgar Filing: AMICUS THERAPEUTICS INC

Ownership Submission

FORM 4

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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3235-0287

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(Print or Type Responses)

1. Name and Address of Reporting Person ^*

FHM IV LP

2. Issuer Name and Ticker or Trading Symbol
AMICUS THERAPEUTICS INC [FOLD]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

_____ Director	__X__ 10% Owner
_____ Officer (give title below)	_____ Other (specify below)

(Last)

(First)

(Middle)

601 UNION STREET, SUITE 3200

3. Date of Earliest Transaction (Month/Day/Year)
03/06/2008

(Street)

SEATTLE, WA 98101

4. If Amendment, Date Original Filed(Month/Day/Year)

6. Individual or Joint/Group Filing(Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person

(City)

(State)

(Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
1.Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	Code	V	Amount	(A) or (D)	Price		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
Common Stock	03/06/2008		P		192	A	$ 9.9	893,210	I	By Frazier Healthcare V, LP ⁽¹⁾ ⁽²⁾
Common Stock	03/06/2008		P		500	A	$ 9.92	893,710	I	By Frazier Healthcare V, LP ⁽¹⁾ ⁽²⁾
Common Stock	03/06/2008		P		1,100	A	$ 9.93	894,810	I	By Frazier Healthcare V, LP ⁽¹⁾ ⁽²⁾
Common Stock	03/06/2008		P		800	A	$ 9.935	895,610	I	By Frazier Healthcare V, LP ⁽¹⁾ ⁽²⁾
Common Stock	03/06/2008		P		300	A	$ 9.94	895,910	I	By Frazier Healthcare V, LP ⁽¹⁾ ⁽²⁾
Common Stock	03/06/2008		P		192	A	$ 9.95	896,102	I	By Frazier Healthcare V, LP ⁽¹⁾ ⁽²⁾
Common Stock	03/06/2008		P		1,000	A	$ 9.955	897,102	I	By Frazier Healthcare V, LP ⁽¹⁾ ⁽²⁾
Common Stock	03/06/2008		P		993	A	$ 9.96	898,095	I	By Frazier Healthcare V, LP ⁽¹⁾ ⁽²⁾
Common Stock	03/06/2008		P		600	A	$ 9.965	898,695	I	By Frazier Healthcare V, LP ⁽¹⁾ ⁽²⁾
Common Stock	03/06/2008		P		800	A	$ 9.9675	899,495	I	By Frazier Healthcare V, LP ⁽¹⁾ ⁽²⁾
Common Stock	03/06/2008		P		400	A	$ 9.97	899,895	I	By Frazier Healthcare V, LP ⁽¹⁾ ⁽²⁾
Common Stock	03/06/2008		P		500	A	$ 9.9725	900,395	I	By Frazier Healthcare V, LP ⁽¹⁾ ⁽²⁾
Common Stock	03/06/2008		P		501	A	$ 9.9775	900,896	I	By Frazier Healthcare V, LP ⁽¹⁾ ⁽²⁾
Common Stock	03/06/2008		P		2,100	A	$ 9.98	902,996	I	By Frazier Healthcare V, LP ⁽¹⁾ ⁽²⁾
Common Stock	03/06/2008		P		1,300	A	$ 9.985	904,296	I	By Frazier Healthcare V, LP ⁽¹⁾ ⁽²⁾
Common Stock	03/06/2008		P		400	A	$ 9.99	904,696	I	By Frazier Healthcare V, LP ⁽¹⁾ ⁽²⁾
Common Stock	03/06/2008		P		1,100	A	$ 9.995	905,796	I	By Frazier Healthcare V, LP ⁽¹⁾ ⁽²⁾
Common Stock	03/06/2008		P		800	A	$ 9.9975	906,596	I	By Frazier Healthcare V, LP ⁽¹⁾ ⁽²⁾
Common Stock	03/06/2008		P		868	A	$ 10	907,464	I	By Frazier Healthcare V, LP ⁽¹⁾ ⁽²⁾
Common Stock	03/06/2008		P		300	A	$ 10.01	907,764	I	By Frazier Healthcare V, LP ⁽¹⁾ ⁽²⁾
Common Stock	03/06/2008		P		37	A	$ 10.07	907,801	I	By Frazier Healthcare V, LP ⁽¹⁾ ⁽²⁾
Common Stock	03/06/2008		P		5,263	A	$ 10.08	913,064	I	By Frazier Healthcare V, LP ⁽¹⁾ ⁽²⁾
Common Stock	03/06/2008		P		200	A	$ 10.12	913,264	I	By Frazier Healthcare V, LP ⁽¹⁾ ⁽²⁾
Common Stock	03/06/2008		P		1,800	A	$ 10.14	915,064	I	By Frazier Healthcare V, LP ⁽¹⁾ ⁽²⁾
Common Stock	03/06/2008		P		100	A	$ 10.18	915,164	I	By Frazier Healthcare V, LP ⁽¹⁾ ⁽²⁾
Common Stock	03/10/2008		P		200	A	$ 9.98	915,364	I	By Frazier Healthcare V, LP ⁽¹⁾ ⁽²⁾
Common Stock	03/10/2008		P		100	A	$ 10.04	915,464	I	By Frazier Healthcare V, LP ⁽¹⁾ ⁽²⁾
Common Stock	03/10/2008		P		100	A	$ 10.07	915,564	I	By Frazier Healthcare V, LP ⁽¹⁾ ⁽²⁾
Common Stock	03/10/2008		P		200	A	$ 10.0775	915,764	I	By Frazier Healthcare V, LP ⁽¹⁾ ⁽²⁾
Common Stock	03/10/2008		P		160	A	$ 10.18	915,924	I	By Frazier Healthcare V, LP ⁽¹⁾ ⁽²⁾

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
	Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.		SEC 1474 (9-02)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security
(Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code
(Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date
(Month/Day/Year)

7. Title and Amount of Underlying Securities
(Instr. 3 and 4)

8. Price of Derivative Security
(Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)

11. Nature of Indirect Beneficial Ownership
(Instr. 4)

Code

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Reporting Owners

Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
FHM IV LP 601 UNION STREET, SUITE 3200 SEATTLE, WA 98101		X
Frazier Healthcare V, LP 601 UNION STREET, SUITE 3200 SEATTLE, WA 98101		X
FHM V, LP 601 UNION STREET, SUITE 3200 SEATTLE, WA 98101		X
FHM V, LLC 601 UNION STREET, SUITE 3200 SEATTLE, WA 98101		X
FRAZIER HEALTHCARE IV LP 601 UNION STREET, SUITE 3200 SEATTLE, WA 98101		X
FRAZIER AFFILIATES IV LP 601 UNION STREET, SUITE 3200 SEATTLE, WA 98101		X

Signatures

FHM IV, LP, By: FHM IV, LLC, its General Partner, By: /s/ Thomas S. Hodge, Chief Operating Officer		03/10/2008
^**Signature of Reporting Person		Date
Frazier Healthcare V, LP, By: FHM V, LP, its General Partner, By: FHM V, LLC, its General Partner, By: /s/ Thomas S. Hodge, Chief Operating Officer		03/10/2008
^**Signature of Reporting Person		Date
FHM V, LP, By: FHM V, LLC, its General Partner, By: /s/ Thomas S. Hodge, Chief Operating Officer		03/10/2008
^**Signature of Reporting Person		Date
FHM V, LLC, By: /s/ Thomas S. Hodge, Chief Operating Officer		03/10/2008
^**Signature of Reporting Person		Date
Frazier Healthcare IV, LP, By: FHM IV, LP, its General Partner, By: FHM IV, LLC, its General Partner, By: /s/ Thomas S. Hodge, Chief Operating Officer		03/10/2008
^**Signature of Reporting Person		Date
Frazier Affiliates IV, LP, By: FHM IV, LP, its General Partner, By: FHM IV, LLC, its General Partner, By: /s/ Thomas S. Hodge, Chief Operating Officer		03/10/2008
^**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	The securities are owned directly by Frazier Healthcare V, LP. FHM V, LP, a joint filer, serves as the general partner of Frazier Healthcare V, LP and FHM V, LLC, serves as the general partner of FHM V, LP. FHM V, LP and FHM V, LLC disclaim beneficial ownership of the reported securities except to the extent of their pecuniary interest therein.
(2)	There is no direct relationship among or between FHM V, LLC, FHM V, L.P. and Frazier Healthcare V, L.P., on the one hand, and FHM IV, LP, Frazier Healthcare IV, LP and Frazier Affiliates IV, LP, on the other. Beneficial ownership of Issuer shares as described herein and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of the shares for purposes of Section 16 or for any other purpose.
Remarks: Exhibit 99.1 - Joint Filer Information

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Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.