UNITED STATES SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, DC 20549

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FORM 8-K

CURRENT REPORT
Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

Safeguard Scientifics, Inc.
(Exact Name of Registrant as Specified in Charter)

Not applicable
(Former Name or Former Address, if Changed Since Last Report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):

⃞ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

⃞ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

⃞ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

⃞ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

ITEM 2.02.     Results of Operations and Financial Condition

On Friday, February 11, 2011, Peter Boni, Chief Executive Officer of Safeguard Scientifics, Inc. (the “Company”) made a publicized appearance at the Stifel Nicolaus Technology, Communications & Internet Conference which was available by webcast to the general public.  In response to a question from the audience during his presentation, Mr. Boni commented regarding the aggregate revenue of the Company’s partner companies for 2010. The text of Mr. Boni’s comment is attached hereto as Exhibit 99.1 and is hereby incorporated by reference.

On February 17, 2011, the Company issued a press release regarding the date and time of its 2010 year-end earnings call.  Included in that release is certain information regarding the aggregate revenue of the Company’s partner companies for 2010.  A copy of the Company’s press release is attached hereto as Exhibit 99.2 and is hereby incorporated by reference.

This information shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (“Exchange Act”), or incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such a filing.

ITEM 9.01.     Financial Statements and Exhibits

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

EXHIBIT INDEX