UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 14A

           Proxy Statement Pursuant to Section 14(a) of the Securities
                              Exchange Act of 1934

Filed by the Registrant |X|
Filed by a Party other than the Registrant |_|
Check the appropriate box:

|_|   Preliminary Proxy Statement

|_|   Confidential, for Use of the Commission Only (as permitted by Rule
      14a-6(e)(2))

|X|   Definitive Proxy Statement

|_|   Definitive Additional Materials

|_|   Soliciting Material Under Rule 14a-12

                              Alfacell Corporation
                (Name of Registrant as Specified In Its Charter)

                                       N/A
    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):

|X|   No Fee required

|_|   Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.

1)    Title of each class of securities to which transaction applies:

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2)    Aggregate number of securities to which transaction applies:

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3)    Per unit price or other underlying value of transaction computed pursuant
      to Exchange Act Rule 0-11 (Set forth the amount on which the filing fee is
      calculated and state how it was determined):

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5)    Total fee paid:


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|_|   Fee paid previously with preliminary materials:

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|_|   Check box if any part of the fee is offset as provided by Exchange Act
      Rule 0-11(a)(2) and identify the filing for which the offsetting fee was
      paid previously. Identify the previous filing by registration statement
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      1)    Amount Previously Paid:

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      4)    Date Filed:

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                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS

                           TO BE HELD JANUARY 19, 2006

To Our Stockholders:

      We are pleased to notify you that the annual meeting of stockholders (the
"Annual Meeting") of Alfacell Corporation, a Delaware corporation ("Alfacell" or
the "Company"), will be held at the Somerset Marriott Hotel, 110 Davidson
Avenue, Somerset, New Jersey, 08873 on Thursday, January 19, 2006 at 2:00 p.m.
local time, for the following purposes as more fully described in the
accompanying Proxy Statement:

      1.    To elect seven directors, each for a term of one year, to hold
            office until the fiscal 2006 Annual Meeting of Stockholders and
            until their successors are elected and qualified (Proposal No.1);

      2.    To ratify the appointment of J.H. Cohn LLP, independent registered
            public accounting firm, to audit the financial statements of the
            Company for the fiscal year ending July 31, 2006 (Proposal No. 2);
            and

      3.    To transact such other matters as may properly come before the
            Annual Meeting or any postponement or adjournment thereof.

      Only stockholders of record of the Company's Common Stock, par value $.001
per share (the "Common Stock"), at the close of business on November 28, 2005
are entitled to vote at the Annual Meeting or at any postponement or adjournment
thereof.

      WE HOPE THAT AS MANY STOCKHOLDERS AS POSSIBLE WILL PERSONALLY ATTEND THE
ANNUAL MEETING. WHETHER OR NOT YOU PLAN TO ATTEND THE ANNUAL MEETING, PLEASE
COMPLETE THE ENCLOSED PROXY CARD AND SIGN, DATE AND RETURN IT PROMPTLY SO THAT
YOUR SHARES WILL BE REPRESENTED. SENDING IN YOUR PROXY WILL NOT PREVENT YOU FROM
VOTING IN PERSON AT THE ANNUAL MEETING.

                               By Order of the Board of Directors,


                               /s/ Kuslima Shogen
                               Kuslima Shogen
                               Chief Executive Officer and Chairman of the Board

December 16, 2005



                                TABLE OF CONTENTS



                                                                                                    Page
                                                                                                    ----
                                                                                                  
PROXY STATEMENT AND NOTICE OF ANNUAL MEETING OF STOCKHOLDERS..........................................3

ABOUT THE MEETING.....................................................................................3

   What is the purpose of the Annual Meeting?.........................................................3

   Who is entitled to vote?...........................................................................3

   Who can attend the meeting?........................................................................3

   What constitutes a quorum?.........................................................................3

   How do I vote?.....................................................................................4

   Can I vote by telephone or electronically?.........................................................4

   Can I change my vote after I return my proxy card?.................................................4

   What are the Board's recommendations?..............................................................4

   What vote is required to approve each item?........................................................4

STOCK OWNERSHIP.......................................................................................5

   Who are the largest owners of Alfacell's stock?....................................................5

   How much stock do Alfacell's directors and executive officers own?.................................6

   Section 16(a) beneficial ownership reporting compliance............................................7

PROPOSAL NO. 1 -- ELECTION OF DIRECTORS...............................................................7

   Director nomination process........................................................................7

   Nominees standing for election to the Board........................................................9

   Business experience of nominees to the Board.......................................................9

   Family relationships..............................................................................11

   Board recommendation and stockholder vote required................................................11

   How often did the Board meet during 2005?.........................................................11

   Which directors are "independent"?................................................................11

   How are directors compensated?....................................................................11

DIRECTORS' STOCK OPTIONS.............................................................................12

BOARD COMMITTEE MEMBERSHIP...........................................................................12

   What committees has the Board established?........................................................12

REPORT OF THE AUDIT COMMITTEE OF THE BOARD OF DIRECTORS..............................................14

COMMUNICATIONS WITH DIRECTORS........................................................................15

PRINCIPAL ACCOUNTANT FEES AND SERVICES...............................................................15

IDENTIFICATION OF EXECUTIVE OFFICERS.................................................................15

BUSINESS EXPERIENCE OF EXECUTIVE OFFICERS............................................................15



                                       i



                                                                                                  
SUMMARY COMPENSATION TABLE...........................................................................16

OPTION GRANTS IN LAST FISCAL YEAR....................................................................17

AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR AND FISCAL YEAR-END OPTION VALUES....................17

COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION..........................................18

REPORT OF THE COMPENSATION COMMITTEE OF THE BOARD OF DIRECTORS.......................................18

   Chief Executive Officer's Compensation............................................................18

STOCKHOLDER RETURN PERFORMANCE GRAPH.................................................................19

CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS.......................................................19

PROPOSAL NO. 2 -- RATIFICATION OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM......................20

   Board recommendation and stockholder vote required................................................20

CODE OF ETHICS.......................................................................................20

ANNUAL REPORT TO STOCKHOLDERS........................................................................20

STOCKHOLDERS' PROPOSALS..............................................................................20

GENERAL..............................................................................................21

OTHER MATTERS........................................................................................21



                                       ii


                              Alfacell Corporation
                              225 Belleville Avenue
                          Bloomfield, New Jersey 07003

                    ----------------------------------------

                          PROXY STATEMENT AND NOTICE OF
                         ANNUAL MEETING OF STOCKHOLDERS

                    ----------------------------------------

      Alfacell  Corporation  ("Alfacell"  or the  "Company") is furnishing  this
Proxy Statement and the enclosed proxy card in connection with the  solicitation
of  proxies  by the Board of  Directors  of the  Company  for use at the  Annual
Meeting of Stockholders to be held on Thursday,  January 19, 2006,  beginning at
2:00 p.m., at the Somerset  Marriott Hotel, 110 Davidson Avenue,  Somerset,  New
Jersey, 08873 and at any postponements or adjournments  thereof. The approximate
date of  mailing  for this Proxy  Statement  and proxy card as well as a copy of
Alfacell's 2005 Annual Report is December 16, 2005.

                                ABOUT THE MEETING

What is the purpose of the Annual Meeting?

      At  Alfacell's  Annual  Meeting,  stockholders  will act upon the  matters
outlined in the accompanying notice of meeting, including:

      o     the election of directors;

      o     the  ratification of our independent  registered  public  accounting
            firm.

      In addition,  management  will report on our  performance  during 2005 and
respond to questions from stockholders.

Who is entitled to vote?

      Only  stockholders of record of the Company's Common Stock at the close of
business on the record date,  November 28, 2005,  are entitled to receive notice
of the Annual  Meeting and to vote the shares of Common  Stock that they held on
that date at the meeting,  or any  postponement  or  adjournment of the meeting.
Each outstanding share of the Company's Common Stock entitles its holder to cast
one vote on each matter to be voted upon. There are no cumulative voting rights.

Who can attend the meeting?

      All  stockholders as of the record date, or their duly appointed  proxies,
may attend the meeting. Cameras,  recording devices and other electronic devices
will not be permitted  at the meeting.  Please note that if you hold your shares
in "street name" (that is, through a broker or other nominee),  you will need to
bring a copy of a brokerage statement  reflecting your stock ownership as of the
record date and check in at the registration desk at the meeting.

What constitutes a quorum?

      The  presence at the meeting,  in person or by proxy,  of the holders of a
majority of the shares of Common  Stock issued and  outstanding  and entitled to
vote on the record date,  will  constitute a quorum,  permitting  the meeting to
conduct its business.  As of November 28, 2005,  the record date,  approximately
36,666,317 shares of Alfacell's Common Stock were outstanding.  Proxies received
but  marked  as  abstentions  and  broker  non-votes  will  be  included  in the
calculation of the number of shares considered present at the meeting.


                                       3


How do I vote?

      If you complete and properly sign the  accompanying  proxy card and return
it to us, it will be voted as you direct. If you are a registered stockholder as
of the record date and attend the meeting,  you may deliver your completed proxy
card in person.  "Street name" stockholders who wish to vote at the meeting will
need to obtain a proxy card from the institution that holds their shares.

Can I vote by telephone or electronically?

      No. We have not  instituted  any  mechanism  for  telephone or  electronic
voting.  However,  "street name" stockholders may be able to vote electronically
through their brokers. If so, instructions  regarding  electronic voting will be
provided  by the  broker  as part  of the  package  which  includes  this  proxy
statement.

Can I change my vote after I return my proxy card?

      Yes. Even after you have submitted your proxy, you may change your vote at
any time  before the proxy is  exercised  by filing  with  Alfacell's  Secretary
either a notice of revocation or a duly executed proxy bearing a later date. The
powers of the proxy  holders  will be  suspended  if you attend  the  meeting in
person and  request  that the  previously  granted  proxy be  revoked,  although
attendance at the meeting will not by itself revoke a previously granted proxy.

What are the Board's recommendations?

      Unless you give other  instructions  on your proxy card, the persons named
as  proxy  holders  on  the  proxy  card  will  vote  in  accordance   with  the
recommendations  of the Board of Directors.  The Board's  recommendation  is set
forth  together with the  description of each item in this proxy  statement.  In
summary, the Board recommends a vote:

      o     FOR election of the nominated slate of directors (see page 11);

      o     FOR  ratification  of the appointment of J.H. Cohn LLP as Alfacell's
            independent registered public accounting firm (see page 20);

      Pursuant  to  the  provisions  of  Rule  14a-4(c)  promulgated  under  the
Securities  Exchange Act of 1934, with respect to any other matter that properly
comes before the meeting,  the proxy  holders  will vote as  recommended  by the
Board of Directors or, if no recommendation is given, in their own discretion.

What vote is required to approve each item?

      Election of directors.  The  affirmative  vote of a plurality of the votes
cast at the meeting,  represented in person or by proxy and entitled to vote, is
required for the election of directors.

      Other  proposals.  For each other proposal,  the  affirmative  vote of the
holders of at least a majority of the shares  represented  in person or by proxy
at the  meeting  and  entitled  to vote on the  proposal  will be  required  for
approval.

      Votes cast  "FOR" a  proposal  constitute  affirmative  votes.  A properly
executed  proxy card marked  "WITHHOLD"  or  "ABSTAIN"  with respect to any such
matter  will  not be voted  on such  matter,  although  it will be  counted  for
purposes of determining  whether there is a quorum and in determining the number
of shares  necessary for approval of such matter.  Accordingly,  a "WITHHOLD" or
"ABSTAIN" will have the effect of a negative vote.

      Broker   non-votes.   Where  brokers  are   prohibited   from   exercising
discretionary  authority  for  beneficial  owners who have not  provided  voting
instructions (commonly referred to as "broker non-votes"), such broker non-votes
will be treated as shares  that are  present for  purposes  of  determining  the
presence of a quorum;  however,  with  respect to  proposals  which  require the
affirmative  vote of a percentage  of shares  present at the Annual  Meeting and
entitled to vote on such proposal for approval,  such broker  non-votes  will be
treated as not  present  for  purposes  of  determining  the outcome of any such
matter.  With  respect to  proposals  which  require the  affirmative  vote of a


                                       4


percentage of the outstanding  shares for approval,  since such broker non-votes
are not cast  "FOR" a  particular  matter,  they  will  have the same  effect as
negative votes or votes cast "AGAINST" such proposals.

                                 STOCK OWNERSHIP

Who are the largest owners of Alfacell's stock?

      The following table sets forth certain  information as of October 31, 2005
concerning  stock  ownership  of  all  persons  known  by  the  Company  to  own
beneficially 5% or more of the outstanding shares of the Company's Common Stock.

                 Security Ownership of Certain Beneficial Owners



Name and address of beneficial                 Amount and Nature of Beneficial       Percent of shares
owner or identity of group                                 Ownership                  outstanding(1)
------------------------------                 -------------------------------       -----------------

                                                                                    
McCash Family Limited Partnership                        9,148,652(2)                     21.1%
N3820 S. Grand Oak Drive
Iron Mountain, MI 49801

McCash, James O., and Trust                              3,652,991(3)                      9.9%
N3820 S. Grand Oak Drive
Iron Mountain, MI 49801

The Knoll Group(4)                                       3,333,180(5)                      8.8%
200 Park Avenue, Suite 3900
New York, NY 10166

Michael A. Roth and Brian J. Stark(6)                    2,095,254(7)                      5.7%
3600 South Lake Drive
St. Francis, WI 53235


----------

(1)   The percentage of stock  outstanding for each stockholder is calculated by
      dividing (i) the number of shares deemed to be  beneficially  held by such
      stockholder  as of the date of the  calculation by (ii) the sum of (A) the
      number  of  shares  of  Common  Stock  outstanding  as of the  date of the
      calculation,  plus (B) the  number of shares  issuable  upon  exercise  of
      options or warrants held by such stockholder  which were exercisable as of
      the date of the  calculation  or which will become  exercisable  within 60
      days after the date of the calculation.

(2)   Includes   6,627,090  shares  subject  to  warrants  which  are  currently
      exercisable or which will become exercisable within 60 days of October 31,
      2005. This information concerning the stock ownership of the McCash Family
      Limited  Partnership  was obtained from the Schedule  13D/A filed with the
      Securities  and Exchange  Commission on May 5, 2005 and other  information
      known to the Company.

(3)   Includes 120,000 shares subject to warrants which will become  exercisable
      within 60 days of October 31, 2005. This information  concerning the stock
      ownership  of the  McCash,  James  O.,  and Trust  was  obtained  from the
      Schedule 13G/A filed with the Securities and Exchange Commission on May 5,
      2005.

(4)   Pursuant to Section  13(d)(3) of the Exchange Act and for purposes of this
      table, Knoll Capital  Management LP, Fred Knoll and Europa  International,
      Inc. are deemed to be a "group" and therefore are collectively referred to
      as The Knoll Group.

(5)   Includes  1,185,000  warrants all of which are currently  exercisable  for
      shares of Common Stock as of October 31, 2005. This information concerning
      the stock  ownership of Knoll  Capital  Management  was obtained  from the
      Schedule 13G filed with the Securities  and Exchange  Commission on August
      25, 2004.


                                       5


(6)   Michael  A. Roth and Brian J. Stark are the joint and  indirect  owners of
      the aforementioned  stock. They are the managing members of Stark Offshore
      Management, LLC, ("Stark Offshore"),  which acts as investment manager and
      has sole power to direct the  management  of SF  Capital  Partners,  Ltd.,
      which  directly  holds all of the shares of Common  Stock.  Through  Stark
      Offshore, Messrs. Roth and Stark possess sole voting and dispositive power
      over all of the foregoing  shares.  This information  concerning the stock
      ownership of Messrs.  Roth and Stark was obtained from the Schedule  13G/A
      filed with the Securities and Exchange Commission on February 14, 2005.

(7)   This does not include  1,041,858  shares of Common Stock that are issuable
      to the stockholders pursuant to certain outstanding  warrants,  because as
      of October  31,  2005 such  warrants  were not  exercisable  nor will they
      automatically become exercisable within 60 days after October 31, 2005.

How much stock do Alfacell's directors and executive officers own?

      The table  below shows the amount of Alfacell  Common  Stock  beneficially
owned  (unless  otherwise  indicated)  by  Alfacell's  directors  and  executive
officers  individually,  and  Alfacell's  directors and executive  officers as a
group. All information is as of October 31, 2005.

                        Security Ownership of Management



                                                                                 Amount and Nature      Percent of
Name and address of beneficial                                                     of Beneficial          shares
owner or identity of group(1)                      Position                         Ownership(2)      outstanding(3)
---------------------------------           --------------------------           -----------------    --------------
                                                                                                    
Kuslima Shogen                              Chief Executive Officer,                 1,307,445(4)            3.5%
                                            Chairman of the Board

John P. Brancaccio                          Director                                    33,750(5)            *

Stephen K. Carter, M.D.                     Director                                   155,000(6)            *

Donald R. Conklin                           Director                                   470,500(7)            1.3%

James J. Loughlin                           Director                                    36,250(8)            *

Robert D. Love                              Chief Financial Officer                     50,000(9)            *

Andrew P. Savadelis                         Director                                   151,250(10)           *

David Sidransky, M.D.                       Director, Chairman of the                  103,750(11)           *
                                            Scientific Advisory Board

Paul M. Weiss, Ph.D.                        Director                                    85,000(12)           *

All executive officers and directors as a                                            2,392,945(13)           6.3%
group (9 persons)


----------
*     Represents less than 1% of Alfacell's outstanding Common Stock.

(1)   Unless otherwise indicated below, the persons in the above table have sole
      voting and investment power with respect to all shares  beneficially owned
      by them.  The  address of all  executive  officers  and  directors  is c/o
      Alfacell  Corporation,  225  Belleville  Avenue,  Bloomfield,  New Jersey,
      07003.

(2)   All shares listed are Common  Stock.  Except as discussed  below,  none of
      these  shares are subject to rights to acquire  beneficial  ownership,  as
      specified  in Rule  13d-3(1)  under the Exchange  Act, and the  beneficial
      owner has sole voting and investment power,  subject to community property
      law where applicable.

(3)   The percentage of stock  outstanding for each stockholder is calculated by
      dividing (i) the number of shares deemed to be  beneficially  held by such
      stockholder  as of October  31,  2005 by (ii) the sum of (A) the number of
      shares of Common  Stock  outstanding  as of October  31, 2005 plus (B) the
      number of shares  issuable  upon  exercise of options or warrants  held by
      such  stockholder  which were  exercisable as of October 31, 2005 or which
      will  become  exercisable  within 60 days  after  October  31,  2005.


                                       6


(4)   Includes  150,000  shares  pledged in 1997 by Ms. Shogen to secure a loan.
      The lender is now claiming that such shares were transferred by Ms. Shogen
      to the lender in February  2003. Ms. Shogen denies that such transfer took
      place  and  believes  that she  maintains  beneficial  ownership  of those
      shares.  She has filed a  lawsuit  against  the  lender  to  resolve  this
      dispute.  However,  since the  lender is  alleging  that the  shares  were
      transferred,  Ms.  Shogen filed a Form 4 to reflect the alleged  transfer.
      Ms. Shogen is vigorously  maintaining  the position that the filing of the
      Form 4 does  not  reflect  the  transfer  of  shares.  If  Ms.  Shogen  is
      successful  in her lawsuit she will file an  amendment to the Form 4. Also
      includes 758,000 shares underlying options which are currently exercisable
      or which will  become  exercisable  within 60 days  October  31,  2005 and
      110,000  shares  underlying  warrants  which are currently  exercisable or
      which will become exercisable within 60 days after October 31, 2005.

(5)   Includes 33,750 shares underlying options which are currently  exercisable
      or which will become exercisable within 60 days after October 31, 2005.

(6)   Includes 155,000 shares underlying options which are currently exercisable
      or which will become exercisable within 60 days after October 31, 2005.

(7)   Includes 85,000 shares underlying options which are currently  exercisable
      or which will become exercisable within 60 days after October 31, 2005 and
      110,000  shares  underlying  warrants  which are currently  exercisable or
      which will become exercisable within 60 days after October 31, 2005.

(8)   Includes 33,750 shares underlying options which are currently  exercisable
      or which will become exercisable within 60 days after October 31, 2005.

(9)   Includes 50,000 shares underlying options which are currently  exercisable
      or which will become exercisable within 60 days after October 31, 2005.

(10)  Includes 151,750 shares underlying options which are currently exercisable
      or which will become exercisable within 60 days after October 31, 2005.

(11)  Includes 63,750 shares underlying options which are currently  exercisable
      or which will become exercisable within 60 days after October 31, 2005.

(12)  Includes 72,500 shares underlying options which are currently  exercisable
      or which will become exercisable within 60 days after October 31, 2005.

(13)  Includes all shares owned  beneficially by the directors and the executive
      officers named in the table.

Section 16(a) beneficial ownership reporting compliance

      Based upon a review of filings with the Securities and Exchange Commission
and written  representations  of certain reporting persons that no other reports
were  required,  we believe that during  fiscal year 2005 all of our  directors,
executive officers and beneficial owners of more than 10% of any class of equity
securities complied on a timely basis with the reporting requirements of Section
16(a) of the Securities Exchange Act of 1934, as amended.

                     PROPOSAL NO. 1 -- ELECTION OF DIRECTORS

      Under  Alfacell's  By-laws,  all  directors  elected by  stockholders  are
elected for a one-year  term.  Each of the  nominees  has  consented  to serve a
one-year term. If any of them should become  unavailable to serve as a director,
the Board may designate a substitute nominee. In that case, the persons named as
proxies will vote for the substitute nominee designated by the Board.

Director nomination process

      The Board of Directors  (the "Board") does not have a standing  nominating
committee or nominating  committee  charter.  Nominees are  recommended  for the
Board's  selection  by a majority  of our  directors  meeting the  criteria  for
independence   as  required  by  the  Nasdaq  Stock  Market  (the   "Independent
Directors").  The  Company  believes  it is  appropriate  not to have a standing
nominating  committee  because  we feel  that  obtaining  an input  from all the
Independent Directors in connection with the nominations enhances the nomination
process.


                                       7


      CRITERIA FOR BOARD MEMBERSHIP. The Board determines the required selection
criteria and  qualifications  of director  nominees  based upon the needs of the
Company at the time  nominees  are  considered.  Directors  should  possess  the
highest personal and professional ethics, integrity and values, and be committed
to  representing  the  long-term  interests of the  Company's  stockholders.  In
evaluating  a  candidate  for  nomination  as a  director  of the  Company,  the
Independent  Directors will consider criteria  including  business and financial
expertise;  geography;  experience as a director of a public company; gender and
ethnic diversity on the Board;  and general criteria such as ethical  standards,
independent  thought,  practical  wisdom  and  mature  judgment.  The Board will
consider these criteria for nominees identified by the Independent Directors, by
stockholders, or through some other source.

      These general  criteria are subject to modification and the Board shall be
able, in the exercise of its discretion,  to deviate from these general criteria
from  time to  time,  as the  Board  may  deem  appropriate  or as  required  by
applicable laws and regulations.

      STOCKHOLDER  NOMINEES.  The Independent  Directors will consider qualified
candidates  for  possible   nomination  that  are  submitted  by  the  Company's
stockholders.  Stockholders  wishing  to  make  such a  submission  may do so by
sending the following  information to the Board c/o Chief  Executive  Officer at
225  Belleville  Avenue,  Bloomfield,  New Jersey  07003  within  the  timeframe
described under the caption, "Stockholder Proposals" below.

      o     Name, age and contact information of the candidate;

      o     A brief biographical sketch and resume;

      o     Written consent  evidencing the candidate's  willingness to be named
            in the proxy and to serve as a director if elected;

      o     A description  of all  arrangements  or  understandings  between the
            stockholder  and the candidate and any other person  relating to the
            candidate;

      o     A signed statement as to the submitting stockholder's current status
            as a stockholder and the number of shares currently held; and

      o     All other  information about the candidate that would be required to
            be  included  in the  proxy  statement  soliciting  proxies  for the
            election of directors under the rules promulgated under the Exchange
            Act.

      PROCESS FOR IDENTIFYING AND EVALUATING NOMINEES. The Independent Directors
believe  Alfacell is  well-served  by its  current  directors.  In the  ordinary
course,  absent special  circumstances  or a material change in the criteria for
Board  membership,  the  Independent  Directors will recommend to the Board that
they  renominate  incumbent  directors  who continue to be  qualified  for Board
service and are willing to continue as  directors.  If an incumbent  director is
not standing for re-election, or if a vacancy on the Board occurs between annual
stockholder  meetings,   the  Independent  Directors  will  seek  out  potential
candidates  for Board  appointment  who meet the  criteria  for  selection  as a
nominee and have the specific  qualities or skills being sought. The Independent
Directors conduct a process of making a preliminary  assessment of each proposed
nominee based upon the resume and biographical information, an indication of the
individual's  willingness  to  serve  and  other  background  information.  This
information is evaluated  against the criteria set forth above and the Company's
specific  needs  at  that  time.  Based  upon a  preliminary  assessment  of the
candidate(s),  those who appear best suited to meet the  Company's  needs may be
invited to participate  in a series of  interviews,  which are used as a further
means of evaluating  potential  candidates.  On the basis of information learned
during this process at least a majority of the Independent Directors, determines
which  nominee(s)  to  recommend  to the  Board  for  inclusion  as the slate of
candidates that the Board  recommends for election at each annual meeting of the
Company's stockholders.

      The Board uses the same process for evaluating all nominees, regardless of
the original source of the nomination.


                                       8


Nominees standing for election to the Board



                                                                                       Current Position
        Name                             Age        Director Since (1)                   With Company
-------------------------               -----       ------------------    ----------------------------------------
                                                                 
Kuslima Shogen                            60               1981           Chief Executive Officer, Chairman of the
                                                                          Board

John P. Brancaccio                        57               2004           Director

Stephen K. Carter, M.D.                   67               1997           Director

Donald R. Conklin                         69               1997           Director

James J. Loughlin                         62               2004           Director

David Sidransky, M.D.                     46               2004           Director, Chairman of the Scientific
                                                                          Advisory Board

Paul M. Weiss, Ph.D.                      47               2003           Director


(1)   The current term of each director expires on the Annual Meeting for fiscal
      year 2005 to be held on January 19, 2006.

Business experience of nominees to the Board

      The nominees have provided the following information about their principal
occupation, business experience and other matters.

      Kuslima Shogen has served as our Chief  Executive  Officer since September
1986,  as Chairman of the Board  since  August 1996 and as a Director  since our
inception.  She also served as our Acting Chief Financial  Officer from June 23,
1999 until  March 2004,  as our Chief  Financial  Officer  from  September  1986
through July 1994 and as our President  from  September  1986 through July 1996.
Ms. Shogen formed the company in 1981 to pursue  research that she had initiated
while a biology student in the University Honors Program at Fairleigh  Dickenson
University.  Prior  to our  founding,  from  1976 to 1981  she was  founder  and
president of a biomedical  research  consortium  specializing in Good Laboratory
Practices  and  animal  toxicology.  During  that  time,  she also  served  as a
consultant  for the Lever  Brothers  Research  Group.  Ms.  Shogen has  received
numerous awards for achievements in biology,  including the Sigma Xi first prize
from the  Scientific  Research  Society of North America in 1974 and first prize
for the most  outstanding  research  paper in  biology  at the  Eastern  College
Science  Conferences  competitions  in 1972,  1973,  and 1974. She earned a B.S.
degree in 1974,  M.S.  in 1976 and also  completed  graduate  studies in 1978 in
embryology  from  Fairleigh  Dickenson  University.  In April 1998,  Ms.  Shogen
received the Pinnacle Award from FDU, the highest honor the  University  bestows
on its graduates. She is a Phi Beta Kappa graduate.

      John P.  Brancaccio  joined the Board of  Directors in January  2004.  Mr.
Brancaccio has been the chief  financial  officer of  Accelerated  Technologies,
Inc., an incubator for venture backed medical device  companies.  He also serves
on the boards of Callisto  Pharmaceuticals,  Inc. and FermaVir  Pharmaceuticals,
Inc. both of which are publicly traded  biopharmaceutical  companies where he is
chairman  of  their  respective  Audit  Committees.  He was  the  secretary  and
treasurer of Memory Pharmaceuticals Corporation from December 2003 to March 2004
after serving in the capacity of their acting chief  financial  officer from May
2002 to December 2003. Prior to Memory Pharmaceuticals,  Mr. Brancaccio held the
positions of chief financial officer and chief operating officer of Eline Group,
a publicly traded entertainment and media company,  where he oversaw the roll up
of  several  related  companies  into the group  and  completed  private  equity
financing  placements.  Prior to joining Eline Group, he held a number of senior
executive   positions  in  public  and  private  companies   including  Atlantic
Pharmaceuticals,  Zambon  Corporation,  Deven  International and Health Learning
Systems.  During his tenure  with these  companies  he  participated  in initial
public  offerings and the  negotiating of licensing and  development  agreements
within both the  pharmaceutical  and biotechnology  industries.  He is a retired
Certified Public Accountant and a graduate of Seton Hall University.


                                       9


      Stephen K. Carter,  M.D.  joined the Board of  Directors  in May 1997.  In
addition,  Dr. Carter serves as a senior clinical consultant to Sugen, Inc. From
1995  through  1997,  he  served  as  Senior  Vice  President  of  Research  and
Development for  Boehringer-Ingelheim  Pharmaceuticals.  Before this, Dr. Carter
spent over 13 years with  Bristol-Myers  Squibb, an international  leader in the
development  of  innovative  anti-cancer  and  anti-viral  therapies.  He held a
variety  of  senior  executive  research  and  development  positions  while  at
Bristol-Myers,  including  serving  for five years as Senior Vice  President  of
worldwide  clinical  research and  development  of its  Pharmaceutical  Research
Institute.  From  1976  to  1982,  he  established  and  directed  the  Northern
California Cancer Program. Prior to this, he held a number of positions during a
nine-year  tenure at the National  Cancer  Institute,  including the position of
Deputy Director at the National  Institutes of Health. He has also been a member
of the faculties of the medical schools of Stanford  University,  the University
of California at San Francisco and New York University. Dr. Carter has published
extensively on the development of anti-cancer  drugs, was the co-founding editor
of journals devoted to cancer therapeutics or immunology,  and has served on the
editorial  boards  of a  number  of  additional  journals  dedicated  to  cancer
treatment.  He is a member of the  American  Society of Clinical  Oncology,  the
American Association for Cancer Research,  and the Society of Surgical Oncology,
as well as several  other  medical  societies.  Dr.  Carter earned his B.A. from
Columbia  University  and his M.D. from New York Medical  College.  He currently
serves on the Boards of Directors of Cytogen Corporation,  Vion Pharmaceuticals,
Emisphere Technologies, Inc. and Tapestry Pharmaceuticals, Inc.

      Donald R. Conklin joined the Board of Directors in May 1997.  Prior to his
retirement in May 1997, Mr. Conklin was a senior executive with Schering-Plough,
a major  worldwide  pharmaceutical  firm.  During  his more  than 35 years  with
Schering-Plough,  he held a variety of key management positions within the firm.
From 1986 to 1994, he served as President of Schering-Plough Pharmaceuticals and
Executive  Vice-President of Schering-Plough  Corporation.  In this position, he
was responsible for worldwide pharmaceutical operations, including the launch of
INTRON  A(R)  (interferon  alfa-2b).  Prior to this,  Mr.  Conklin had served as
President  of  Schering  USA and  had  held a  variety  of  executive  marketing
positions in the United States, Europe, and Latin America. Immediately preceding
his retirement,  he was Chairman of Schering-Plough  Health Care Products and an
Executive Vice President of  Schering-Plough  Corporation.  Mr. Conklin received
his B.A. with highest  honors from Williams  College and his M.B.A.  degree from
the Rutgers  University School of Business.  He currently serves on the Board of
Directors of Ventiv Health, Inc.

      James J.  Loughlin  joined the Board of  Directors  in January  2004.  Mr.
Loughlin retired as a partner with KPMG LLP ("KPMG") in September 2003, where he
was responsible for the  Pharmaceuticals  Practice,  Life Sciences and Chemicals
division.  During his career, Mr. Loughlin served in various executive positions
throughout KPMG,  including Managing Partner of the firm's Milwaukee,  Wisconsin
office, Partner-in-Charge of Human Resources for the United States in the firm's
National Executive Office in New York, and  Partner-in-Charge  of Audit Practice
in the firm's Short Hills,  New Jersey office.  Mr. Loughlin was also elected to
and served on the firm's Board of Directors from 1995 until 2000.  Mr.  Loughlin
has   gained   extensive   experience   serving   multinational   pharmaceutical
manufacturing  and  distribution  companies.  Mr. Loughlin is a Certified Public
Accountant. He received his B.S. in accounting from St. Peter's College.

      David Sidransky,  M.D.,  joined our Board of Directors May 2004 and serves
as Chairman of our  Scientific  Advisory  Board.  Dr.  Sidransky is a founder of
several private  biotechnology  companies and has served on numerous  scientific
advisory  boards of many  private  and public  companies,  including  Medimmune,
Telik, Roche and Amgen. He was formerly on the board of scientific counselors at
the NIDCR and a member of the Recombinant DNA advisory committee at the National
Institute  of Health NIH (RAC).  He is currently  Vice-Chairman  of the Board of
Directors of ImClone Systems.  Dr. Sidransky is on numerous editorial boards and
has served as senior editor of several cancer related journals.  Currently,  Dr.
Sidransky is the Director of the Head and Neck Cancer Research Division at Johns
Hopkins University School of Medicine. In addition, he is Professor of Oncology,
Otolaryngology-Head  and Neck Surgery,  Cellular & Molecular Medicine,  Urology,
Genetics,  and Pathology at John Hopkins University and Hospital.  Dr. Sidransky
is certified in Internal  Medicine and Medical Oncology by the American Board of
Medicine. He has over 300 peer-reviewed  publications,  and has contributed more
than 50 cancer reviews and chapters and also has numerous  issued  biotechnology
patents. He has been the recipient of many awards and honors, including the 1997
Sarstedt International prize from the German Society of Clinical Chemistry, 1998
Alton Ochsner Award Relating Smoking and Health by the American College of Chest
Physicians.


                                       10


      Paul Weiss,  Ph.D.,  joined our Board of Directors in February  2003.  Dr.
Weiss is President of the Gala Biotech business unit of Cardinal Health.  He had
served as a  director  on Gala's  Board  from 1998 to 2001,  when he joined  the
management  team as Senior  Vice  President  of Business  Development.  He later
became  President of Gala and has remained so since the  acquisition  of Gala by
Cardinal  Health in 2003.  Prior to  joining  Gala  Design,  Dr.  Weiss was Vice
President of Technology and Product  Licensing at 3-Dimensional  Pharmaceuticals
(3DP) from 1998 to 2001,  which went  public in 2001 and was later  acquired  by
J&J.  Prior to joining  3DP,  Dr.  Weiss was  Director  of  Licensing  for Wyeth
Pharmaceuticals.  Dr. Weiss holds a Ph.D.  in  Biochemistry  and an MBA from the
University  of  Wisconsin-Madison  and a B.Sc.  in  Biochemistry  from  Carleton
University Institute of Biochemistry in Ottawa, Ontario.

Family relationships

      There are no family  relationships among any of the Company's directors or
executive officers.

Board recommendation and stockholder vote required

      The Board of  Directors  recommends a vote FOR the election of each of the
nominees named above.  (Proposal No. 1 on the proxy card).  The affirmative vote
of a plurality  of the votes  represented  in person or by proxy and entitled to
vote, cast at the meeting is required for the election of directors.

How often did the Board meet during 2005?

      The Board of Directors  met four times  during the 2005 fiscal year.  Each
director  attended at least 75% of the total number of meetings of the Board and
committees on which he or she served.

Which directors are "independent"?

      The Board of Directors has  determined  that the  following  directors are
"independent"  under the current Nasdaq rules:  John P.  Brancaccio,  Stephen K.
Carter, M.D., Donald R. Conklin, James J. Loughlin and Paul M. Weiss, Ph.D.

How are directors compensated?

      Effective  in  January  2005,  the Board  implemented  a new  non-employee
director  compensation policy. Under the new compensation policy, each member of
the Board who is not an  employee  of  Alfacell  receives  $10,000  per annum in
consideration  of the  member's  serving  on the  Board,  payable  in four equal
quarterly  installments.  Each Board  member who was not an employee of Alfacell
also received  $1,000 for each Board meeting  attended in person,  $500 for each
Board meeting attended  telephonically  and reimbursement for travel and related
expenses incurred in connection with attendance at meetings.  Under our director
compensation  policies,  directors  who also serve as executive  officers do not
receive compensation for their service on our board of directors.

      In May  1997  and in  December  1997,  the  Board  of  Directors  and  the
stockholders,  respectively,  approved our 1997 Stock Option Plan, which,  among
other  things,  provides  for  automatic  grants of  options  under a formula to
non-employee directors which are independent directors for purposes of this plan
on an annual  basis.  The formula  provides  that (i) on each December 31st each
independent director  automatically receives an option to purchase 15,000 shares
of our  Common  Stock,  or the  regular  grant;  and  (ii)  on the  date of each
independent  director's  initial  election to the Board of Directors,  the newly
elected independent  director  automatically  receives an option to purchase the
independent  director's  pro rata share of the regular  grant  which  equals the
product of 1,250  multiplied  by the  number of whole  months  remaining  in the
calendar year, or the pro rata grant.  Each option granted pursuant to a regular
grant and a pro rata  grant  vests and  becomes  exercisable  on  December  30th
following  the date of grant.  An option will not become  exercisable  as to any
shares  unless the  independent  director has served  continuously  on the Board
during the year  preceding  the date on which such options are scheduled to vest
and become  exercisable,  or from the date the  independent  director joined the
Board  until the date on which the  options  are  scheduled  to vest and  become
exercisable.   However,  if  an  independent  director  does  not  fulfill  such
continuous  service  requirement  due to the  independent  director's  death  or
disability all options held by the  independent  director  nonetheless  vest and
become  exercisable  as  described  herein.  An option  granted  pursuant to the
formula remains exercisable for a period


                                       11


of five years after the date the option first becomes exercisable. The per share
exercise price of an option granted under the formula is equal to the average of
the high and low trade  prices of our Common  Stock for the twenty (20)  trading
days preceding the date of grant.

      In  addition  to  the  regular  option  grants  awarded  to  each  of  the
independent  or  non-employee  directors  of the Company  during the fiscal year
ended July 31, 2005, the  non-employee  directors  were awarded a  discretionary
grant  pursuant to the 1997 Stock  Option  Plan.  Pursuant to the  discretionary
grants,  each  non-employee  director  was granted an option to  purchase  5,000
shares of our Common  Stock.  The exercise  price and vesting  schedules for the
discretionary  grants  are set  forth  in the  table  titled  "Directors'  Stock
Options" below.

                            DIRECTORS' STOCK OPTIONS

      During the fiscal year ended July 31, 2005,  the following  independent or
non-employee  directors were granted options under  Alfacell's 1997 Stock Option
Plan as set forth above.

                                                 Number of
Name                                             Options(1)     Exercise Price
-----------------------------------              ----------     --------------
John P. Brancaccio                                 20,000            $4.38
Stephen K. Carter, M.D.                            20,000            $4.38
Donald R. Conklin                                  20,000            $4.38
James J. Loughlin                                  20,000            $4.38
David Sidransky, M.D.                              20,000            $4.38
Paul M. Weiss, Ph.D.                               20,000            $4.38

----------
(1)   All the options  listed here were granted on December  31,  2004,  vest on
      December 30, 2005 and expire on December 30, 2010.

                           BOARD COMMITTEE MEMBERSHIP

What committees has the Board established?

      The Board of Directors has standing Compensation and Audit Committees. The
membership  of the standing  committees as of the fiscal year end July 31, 2005,
is set forth in the following table.

                                                   Compensation         Audit
      Name                                           Committee        Committee
      -------------------------------              ------------       ---------
                                                        **                *
      John P. Brancaccio
      Donald R. Conklin                                 *
      James J. Loughlin                                                   **
      Paul M. Weiss, Ph.D.                              *                 *

----------
*     Member

**    Chair

      Compensation  Committee.  All of the  members of  Alfacell's  Compensation
Committee were considered "independent directors," as independence is defined in
Rule  4200(a)(15)  of the National  Association of Securities  Dealers  ("NASD")
listing standards. In fiscal 2005, the Compensation Committee met five times.

The Compensation Committee's primary functions are to:

      o     Approve  executive  compensation,  including the corporate goals and
            objectives to be used in evaluating  the  performance of the CEO and
            determining the CEO's compensation;


                                       12


      o     Approve salary ranges and bonus plans for non-executive officers;

      o     Administering  stock  plans and  benefit  programs  and  approve any
            amendments to existing plans;

      o     Recommend director compensation; and

      o     Review the compensation policy for all of Alfacell's employees.

      Audit  Committee.  All of the members of Alfacell's  Audit  Committee were
considered   "independent   directors,"  as  independence  is  defined  in  Rule
4200(a)(15) of the National  Association of Securities  Dealers ("NASD") listing
standards  and  Section  10A(m)(3)  of the  Exchange  Act.  Alfacell's  Board of
Directors has determined that Mr. Loughlin and Mr. Brancaccio  qualify as "audit
committee  financial  experts" as defined by Item 401(h) of  Regulation  S-K. In
fiscal 2005, the Audit Committee met seven times.

      On November 9, 2003, the Board of Directors adopted Alfacell Corporation's
Audit Committee  Charter.  A copy of the Audit Committee  Charter was previously
included as Exhibit A to Alfacell's Definitive Proxy Statement,  Amendment No. 1
on  Schedule  14A,  previously  filed with the  Commission  on December 8, 2003.
According to the  Charter,  the Audit  Committee  shall be comprised of at least
three directors,  each of whom shall meet the  independence  requirements of the
Nasdaq National  Market and Section  10A(m)(3) of the Securities  Exchange,  and
each of whom shall not have  participated  in the  preparation  of the financial
statements  of the  Company at any time during the past three  years.  The Audit
Committee's purpose, duties and responsibilities under its charter include those
specified  in the  listing  standards  of the Nasdaq  Stock  Exchange  for audit
committees.

      The Charter  describes  the primary  functions  of the Audit  Committee as
follows:

      o     To appoint,  evaluate and, as the  Committee  may deem  appropriate,
            terminate and replace our independent  registered  public accounting
            firm;

      o     To monitor the  independence  of our independent  registered  public
            accounting firm;

      o     To  determine  the  compensation  to  be  paid  to  our  independent
            registered public accounting firm;

      o     To review with  management  and our  independent  registered  public
            accounting firm the effect of regulatory and accounting  initiatives
            as well as off-balance  sheet structures on the Company's  financial
            statements;

      o     To review the experience and qualifications of the senior members of
            the  independent  registered  public  accounting  firm  team and the
            quality  control  procedures  thereof.  To review the experience and
            qualifications of our Company's senior finance executives;

      o     To pre-approve all audit services and permitted  non-audit  services
            to be performed by our independent registered public accounting firm
            and to establish  policies and  procedures for the engagement of our
            independent  registered  public accounting firm to provide permitted
            non-audit services;

      o     To conduct  annual  reviews and  assessments  of the adequacy of our
            Charter and the continued independence of the independent registered
            public  accounting  firm and recommend  any proposed  changes to the
            Board for approval;

      o     To review all related-party  transactions for potential  conflict of
            interest situations and approve such related-party transactions;

      o     To establish  procedures for the confidential and anonymous receipt,
            retention  and  treatment  of  complaints  regarding  the  Company's
            accounting, internal controls and auditing matters; and

      o     To report to the Board on such matters.


                                       13


             REPORT OF THE AUDIT COMMITTEE OF THE BOARD OF DIRECTORS

      As of July 31, 2005, the Audit Committee of Alfacell's  Board of Directors
was composed of James J.  Loughlin,  Chairman,  John P.  Brancaccio  and Paul M.
Weiss, Ph.D., all of whom were non-employee directors.  All members of the Audit
Committee were independent as independence is defined in Rule 4200(a)(15) of the
NASD listing  standards and Section  10A(m)(3) of the Exchange  Act.  Alfacell's
Board of Directors has determined that Messrs.  Loughlin and Brancaccio  qualify
as audit  committee  financial  experts as defined by Item 401(h) of  Regulation
S-K.

      On  November  9,  2003,  the Board of  Directors  adopted a written  Audit
Committee  charter.  Such  charter  requires  the  Company to meet the rules and
regulations of the Securities and Exchange Commission and the Sarbanes-Oxley Act
of 2002.  The  members  of the Audit  Committee  meet  current  audit  committee
requirements.  Alfacell  will  endeavor to  continue  to meet all current  audit
committee  requirements.  The Audit Committee is charged with the responsibility
of selecting and appointing the independent  registered  public  accounting firm
and has chosen to have the selection ratified by stockholders.

      Management  is  responsible  for  Alfacell's  internal  controls  and  the
financial reporting process. Alfacell's independent registered public accounting
firm is responsible for performing an independent audit of Alfacell's  financial
statements  and  management's  assessment  of internal  control  over  financial
reporting in  accordance  with the  standards of the Public  Company  Accounting
Oversight  Board (United  States) and to issue a report on Alfacell's  financial
statements  and  management's  assessment  of internal  control  over  financial
reporting. The Audit Committee's  responsibility is to monitor and oversee these
processes. In carrying out its oversight  responsibilities,  the Audit Committee
is not  providing  any  expert,  professional  or special  assurances  as to our
financial  statements or any  professional  certification.  The Audit  Committee
relies on the information provided and representations made to it by management,
and also on the reports on our  financial  statements  that it receives from our
independent registered public accounting firm.

      In this  context,  the Audit  Committee  has  reviewed and  discussed  the
financial  statements  with  management and our  independent  registered  public
accounting firm.  Management  represented to the Audit Committee that Alfacell's
financial  statements  were prepared in accordance  with  accounting  principles
generally accepted in the United States. The Audit Committee  discussed with the
independent  registered  public accounting firm matters required to be discussed
by Statement on Auditing Standards No. 61, Communications with Audit Committees,
as amended.

      Alfacell's independent registered public accounting firm also provided and
discussed  with  the  Audit  Committee  the  written   disclosure   required  by
Independence Standards Board Standard No. 1 (Independence Discussions with Audit
Committees).   The  Audit   Committee  also  reviewed  and  discussed  with  the
independent registered public accounting firm the firm's independence. The Audit
Committee  found that the  non-audit  services,  as  described  on page 15 under
"Audit-Related  Fees,"  "Tax  Fees,"  and  "All  Other  Fees"  provided  by  the
independent  registered  public  accounting  firm during the year ended July 31,
2005  were  compatible  with  maintaining  the  independent   registered  public
accounting firm' independence.

      Based  upon the  Audit  Committee's  discussion  with  management  and the
independent  registered public accounting firm and the Audit Committee's  review
of the representation of management and the report of the independent registered
public accounting firm to the Audit Committee,  the Audit Committee  recommended
to the Board of Directors that the audited  financial  statements be included in
Alfacell's  Annual  Report on Form 10-K for the year ended  July 31,  2005 filed
with the Securities and Exchange Commission on October 14, 2005.

      In addition,  the Audit Committee has approved the  reappointment  of J.H.
Cohn LLP as our independent  registered  public  accounting firm for fiscal year
2006, and has submitted the  reappointment  to the stockholders for ratification
at this annual meeting. The Audit Committee  pre-approved the terms of the audit
services to be provided by our independent registered public accounting firm for
fiscal year 2006.

      This  report  is  respectfully  submitted  by the  members  of  the  Audit
Committee of the Board.

                                               James J. Loughlin, Chairman
                                               John P. Brancaccio
                                               Paul M. Weiss, Ph.D.


                                       14


                          COMMUNICATIONS WITH DIRECTORS

      Stockholders or other interested parties may communicate with any director
or committee of the Board by writing to them c/o Chairman of the Board, Alfacell
Corporation,  225 Belleville Avenue,  Bloomfield,  New Jersey 07003. Comments or
questions  regarding the  Company's  accounting,  internal  controls or auditing
matters  will be  referred  to  members  of the  Audit  Committee.  Comments  or
questions  regarding the nomination of directors and other corporate  governance
matters will be referred to the appropriate independent directors.

       The Company has a policy of encouraging all directors to attend the
 annual stockholder meetings. All of our directors attended the annual meeting
for fiscal year 2004.

                     PRINCIPAL ACCOUNTANT FEES AND SERVICES

      In accordance with the requirements of the Sarbanes-Oxley Act of 2002 (the
"Act") and the Audit Committee's  charter,  all audit and audit-related work and
all non-audit work performed by the  independent  registered  public  accounting
firm,  J.H. Cohn LLP, is approved in advance by the Audit  Committee,  including
the proposed fees for such work. The Audit Committee is informed of each service
actually rendered that was approved through its pre-approval process.

Audit fees

      Audit  fees  billed  to  Alfacell  by J.H.  Cohn LLP for the  audit of the
financial  statements  and  management's  assessment  of internal  control  over
financial  reporting included in Alfacell's Annual Report on Form 10-K, audit of
reviews of the financial  statements included in Alfacell's Quarterly Reports on
Form 10-Q, work related to Alfacell's  registration  statements and consultation
on accounting topics for the years ended July 31, 2005 and July 31, 2004 totaled
approximately $108,000 and $82,000 respectively.

Audit-related fees

      None.

Tax fees

      None.

All other fees

      None.

                      IDENTIFICATION OF EXECUTIVE OFFICERS



                                                      Current Position
          Name                   Age                    With Company                 Officer Since(1)
     --------------            --------     ------------------------------------     ----------------
                                                                                   
     Kuslima Shogen               60        Chief Executive Officer and Chairman            1981
                                                        of the Board

     Robert D. Love               55              Chief Financial Officer                   2005


      (1)   Officers of Alfacell hold office until their  successors are elected
            and qualified or until their earlier removal, death or resignation.

                    BUSINESS EXPERIENCE OF EXECUTIVE OFFICERS

      Set forth below is certain information regarding the executive officers of
the Company who do not serve on the Board of Directors.

      Robert D. Love has over 25 years of domestic and international  experience
in the pharmaceutical  industry. Mr. Love joined Alfacell as its Chief Financial
Officer in May 2005. He has held  senior-level  positions in Finance,  Corporate
Development  and  Marketing  with P&L  responsibility  at large,  privately-held
companies as well as major, publicly traded global pharmaceutical  corporations.
From 2003 to 2005,  Mr.  Love served as Senior  Vice  President,


                                       15


CFO  and  COO  of   TriGenesis   Therapeutics,   Inc.,   a  start-up   specialty
pharmaceutical company that he co-founded.  From 1998 through 2002, he served as
both Senior Vice  President  in charge of  Business  Partnering  and Senior Vice
President,    Finance    and    Acquisitions    at    Quintiles    Transnational
Corporation/Innovex,  a leading pharmaceutical  services organization.  Prior to
Innovex,  Mr. Love was CFO at Mutual  Pharmaceuticals/United  Research Labs from
1995 to  1998.  From  1976  through  1995,  he held  several  senior  management
positions  at  SmithKline  Beecham,   including  Vice  President  and  Director,
Strategic Product Development - Worldwide from 1993 to 1995, Vice President, CFO
in the UK - one of the Company's largest ex-U.S. operations - from 1991 to 1993,
and  Director,  Finance - North  America  from 1988 to 1991.  Mr. Love began his
career as an  accountant  at Coopers  and  Lybrand in 1972.  He earned a B.A. in
Accounting  from  Rutgers  University  and a  M.B.A.  with  a  concentration  in
Finance/Marketing   from  Villanova   University.   He  is  a  Certified  Public
Accountant.

                           SUMMARY COMPENSATION TABLE

      The following  table provides a summary of cash and non-cash  compensation
for each of the last three fiscal years ended July 31, 2005,  2004 and 2003 with
respect to the person serving as Alfacell's  Chief Executive  Officer during the
year  ended  July  31,  2005,  and  Alfacell's  only  other  executive   officer
(collectively, the "Named Officers").



                                                                                               Long-Term
                                                     Annual Compensation                      Compensation
                                        ----------------------------------------------        ------------
                                                                      Other Annual      Securities Underlying         All Other
Name and Principal Position   Year      Salary ($)      Bonus ($)  Compensation ($)(1)         Options (#)       Compensation ($)(2)
---------------------------   ----      ----------      ---------  -------------------         -----------       -------------------
                                                                                                     
Kuslima Shogen                2005      $207,002           --             --                    250,000                $6,012
Chief Executive Officer,      2004      $150,000(3)        --             --                    300,000                $6,058
Chairman of the Board of      2003      $150,000(3)        --             --                    115,000                $2,077
Directors

Robert D. Love(4)             2005      $ 13,846           --             --                    400,000(5)                 --
Chief Financial Officer       2004            --           --             --                         --                    --
                              2003            --           --             --                         --                    --

Andrew P. Savadelis(6)        2005      $168,692           --             --                         --                $3,738
Senior Vice President,        2004      $ 50,365           --             --                    413,750(6)                 --
Chief Financial Officer,      2003            --           --             --                         --                    --
Director


----------
(1)   Excludes  perquisites and other personal benefits that in the aggregate do
      not  exceed the  lesser of  $50,000  or 10% of the Named  Officer's  total
      annual salary and bonus.

(2)   Consist of Alfacell's annual contributions to a 401(k) plan.

(3)   Unpaid gross salary of $80,780 for the fiscal year ended July 31, 2003 was
      paid during the fiscal year ended July 31, 2004.

(4)   Mr. Love was appointed our Chief Financial Officer on May 23, 2005.

(5)   Mr. Love was granted a ten-year stock option to purchase 400,000 shares of
      our common stock  commensurate with his appointment as our Chief Financial
      Officer.  The options vest and become  exercisable  as to 50,000 shares on
      November  23, 2005,  75,000  shares each on November 23, 2006 and November
      2007 and 100,000 shares each on November 23, 2008 and November 23, 2009.

(6)   Mr. Savadelis left as our Chief Financial  Officer effective as of May 20,
      2005. 262,500 of these options were cancelled at that time.


                                       16


                        OPTION GRANTS IN LAST FISCAL YEAR

      The following  table  contains  information  concerning the grant of stock
options to the Named Officers during the fiscal year ended July 31, 2005:



                                                Individual Grants
                             ---------------------------------------------------------      Potential Realizable Value at
                              Number of       % of Total                                    Assumed Annual Rates of Stock
                              Securities       Options                                      Price Appreciation for Option
                              Underlying      Granted to    Exercise or                                Term (2)
                               Options       Employees in    Base Price    Expiration      ------------------------------
   Name                      Granted (#)     Fiscal Year    ($/Share)(1)       Date            5%($)            10%($)
-------------------------------------------------------------------------------------------------------------------------
                                                                                            
Kuslima Shogen                250,000(3)        26.80%         $6.73         9/12/14       $ 1,058,115        $2,681,472
Robert D. Love                400,000(4)        42.87%         $1.87         5/23/15       $   470,413        $1,192,119
Andrew P. Savadelis                --              --             --            --                  --                --


(1)  The exercise price of these options was based on the closing price of our
     Common Stock on the date of grant.

(2)  The amounts set forth in the two columns represent hypothetical gains that
     might be achieved by the optionees if the respective options are exercised
     at the end of their terms. These gains are based on assumed rates of stock
     price appreciation of 5% and 10%.

(3)  100,000 of these options vest and become exercisable immediately and 50,000
     options each on September 13, 2005, 2006 and 2007.

(4)  50,000 of these options vest and become exercisable on November 23, 2005,
     75,000 shares each on November 23, 2006 and 2007 and 100,000 shares each on
     November 23, 2008 and 2009.

                 AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR
                        AND FISCAL YEAR-END OPTION VALUES

      The following table sets forth the  information  with respect to the Named
Officers  concerning the exercise of options during 2005 and unexercised options
held as of July 31, 2005.



                                                                 Number of Securities                Value of Unexercised
                                                                Underlying Unexercised               In-the-Money Options
                                                                Options at Year-End (#)                at Year-End ($)(2)
                            Shares                           -----------------------------      ------------------------------
                         Acquired on           Value
       Name              Exercise (#)    Realized ($)(1)     Exercisable     Unexercisable      Exercisable      Unexercisable
-------------------      ------------    ---------------     -----------     -------------      -----------      -------------
                                                                                                 
Kuslima Shogen               None              None             645,445          309,000          $881,842         $354,570
Robert D. Love               None              None                0             400,000             $0            $892,000
Andrew P. Savadelis          None              None             151,250             0                $0               $0


----------
(1)   Based on the fair market  value of the  purchased  shares on the  exercise
      date less the share exercise price paid.

(2)   The fair market value of the Common Stock at the fiscal year end was based
      on the  average of the high and low trade  prices  ($2.23)  for the Common
      Stock obtained from the Nasdaq  SmallCap Market on the last trading day of
      the fiscal year ended July 31, 2005.


                                       17


           COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

      During the fiscal  year ended July 31,  2005,  the members of the Board of
Directors  who served on the  Compensation  Committee  were Messrs.  Brancaccio,
Conklin and Weiss.  All such directors are independent  directors and have never
been  officers  of  Alfacell.  During the fiscal  year ended July 31,  2005,  no
executive  officer of Alfacell served on the Compensation  Committee or Board of
Directors of any other entity which had any executive officer who also served on
the Compensation Committee or Board of Directors of Alfacell.

         REPORT OF THE COMPENSATION COMMITTEE OF THE BOARD OF DIRECTORS

      The Compensation  Committee has overall  responsibility for evaluating and
approving the  Company's  executive  officer  compensation  plans,  policies and
programs,  including  compensation  of the Chief Executive  Officer.  During the
fiscal year ended July 31, 2005 the  Compensation  Committee  consisted of three
independent directors. Our compensation program, both for our executive officers
as well as for all employees,  is based on the philosophy  that the interests of
our employees should be closely aligned with those of our stockholders.  As with
many other biotechnology companies,  Alfacell's current level of development and
the highly  volatile nature of  biotechnology  stocks in general makes executive
compensation,  which is normally based on sales and earnings  goals, or strictly
based on stock  performance,  impracticable.  In determining  compensation,  the
Compensation  Committee  generally  reviews the progress made by the  individual
officer in attaining  his or her  individual  goals and the progress made by the
Company  in  its  drug  development  programs.  In  addition,  the  Compensation
Committee keeps the Company's stock performance in mind when making compensation
decisions.  Finally, the Compensation Committee generally reviews and takes into
account competitive factors regarding compensation.  Our compensation program is
based on the following principles:

      o     Compensation  opportunities should attract the best talent, motivate
            individuals to perform at their highest levels,  reward  outstanding
            achievement,  and retain the  leadership  and skills  necessary  for
            building long-term stockholder value;

      o     A bonus  potential  which is tied directly to operating  objectives;
            and

      o     A long-term  incentive  award  generally in the form of stock option
            grants to increase ownership in the Company and encourage executives
            to manage from the perspective of owners of the Company.

Chief Executive Officer's Compensation

      The  compensation  paid in the fiscal  year ended  July 31,  2005,  to the
Company's Chief Executive  Officer and the other executive  officer named in the
Summary Compensation Table above consisted of base salary and stock options. The
compensation  level for each of these  executives  in the fiscal year ended July
31, 2005, was based on the  Compensation  Committee's  evaluation of a number of
factors,  including the executive's position and  responsibilities,  service and
accomplishments and present and expected future value to the Company.

      This report is respectfully  submitted by the members of the  Compensation
Committee of the Board.

                                                   John P. Brancaccio, Chairman
                                                   Donald R. Conklin
                                                   Paul M. Weiss, Ph.D.


                                       18


                      STOCKHOLDER RETURN PERFORMANCE GRAPH

      The graph below  summarizes  the total  cumulative  return  experienced by
Alfacell's  stockholders  during  the  five-year  period  ended  July 31,  2005,
compared to the Nasdaq Stock Market Index and the Nasdaq  Pharmaceutical  Index.
The  changes  for the  periods  shown in the  graph  and  table are based on the
assumption that $100.00 was invested in Alfacell Corporation Common Stock and in
each index below on July 31, 2000 and that all cash dividends  were  reinvested.
The table does not forecast performance of our common stock.

 [THE FOLLOWING TABLE WAS REPRESENTED AS A LINE CHART IN THE PRINTED MATERIAL.]

                                             Cumulative Total Return
                               -------------------------------------------------
                                7/00     7/01    7/02      7/03   7/04     7/05

ALFACELL CORPORATION           100.00   94.89    36.96   145.65  728.24   233.92
NASDAQ STOCK MARKET (U.S.)     100.00   54.55    36.63    47.77   51.74    58.89
NASDAQ PHARMACEUTICAL          100.00   86.27    53.06    79.19   75.11    89.47

                 CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

      At fiscal  years  ended July 31,  2005 and 2004,  $161,342  and  $151,815,
respectively  were due from Kuslima  Shogen,  the Company's  CEO, from which the
Company earned 8% interest in the amount of  approximately  $9,500 on the unpaid
principal balance for each of the fiscal years 2005 and 2004. This loan was made
prior to July 30, 2002 and has not since been  materially  modified,  thus it is
not in violation of the Sarbanes-Oxley Act of 2002.

      In May  2005,  we  issued a  ten-year  stock  option  to Robert D. Love to
purchase  400,000  shares of Common Stock at a per share exercise price of $1.87
in connection with his appointment as Chief Financial Officer of the Company.


                                       19


 PROPOSAL NO. 2 -- RATIFICATION OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

      As part of our implementing the  Sarbanes-Oxley  Act, the Audit Committee,
rather  than  the  full  Board,  selected  our  independent   registered  public
accounting  firm,  reviewed  the  scope of the  annual  audit  and  pre-approved
audit-related  and other services to be performed by the independent  registered
public  accounting firm. After evaluating their  performance in fiscal 2005, the
Audit Committee has selected J.H. Cohn LLP as our independent  registered public
accounting firm for our fiscal year 2006 ending July 31, 2006. You are requested
to ratify the Audit  Committee's  appointment  of J.H.  Cohn LLP as  independent
registered  public accounting firm for our fiscal 2006. A representative of J.H.
Cohn LLP will be present at the Annual Meeting and will have the  opportunity to
make statements if they desire to do so. Such representative is also expected to
be available to respond to appropriate  questions from  stockholders  present at
the meeting.

Board recommendation and stockholder vote required

      The  Board  of  Directors  recommends  a  vote  FOR  ratification  of  the
appointment  of  J.H.  Cohn  LLP as  Alfacell's  independent  registered  public
accounting  firm for the year ending July 31, 2006  (Proposal No. 2 on the proxy
card). The affirmative vote of a majority of the shares represented in person or
by proxy at the meeting and  entitled to vote on the  proposal  will be required
for approval.

      If the  appointment  is not  ratified,  the Audit  Committee  will  select
another  independent  registered  public  accounting firm. If the appointment is
ratified,  the Audit Committee reserves the right to appoint another independent
registered public accounting firm.

                                 CODE OF ETHICS

      Alfacell has adopted a written Code of Business  Conduct and Ethics ("Code
of Ethics") that applies to the Company's principal executive officer, principal
financial officer, principal accounting officer, controller and to all its other
employees.  These  standards  are a guide to help ensure that all our  employees
live  up to our  high  ethical  standards.  A copy  of the  Code  of  Ethics  is
maintained on our website at www.alfacell.com.

      We intend to post on our  website,  any  amendment  to or waiver  from any
provision in our Code of Ethics that applies to our principal executive officer,
principal  financial officer,  principal  accounting  officer or controller,  or
persons  performing  similar  functions,  and that relates to any element of the
standards enumerated in the rules of the Securities and Exchange Commission.

                          ANNUAL REPORT TO STOCKHOLDERS

      Alfacell's  2005 Annual Report to Stockholders on Form 10-K for the fiscal
year ended July 31, 2005, including audited financial statements, filed with the
Securities and Exchange  Commission on October 14, 2005,  accompanies this proxy
statement.

                             STOCKHOLDERS' PROPOSALS

      It  is  anticipated   that  Alfacell's   fiscal  2006  Annual  Meeting  of
Stockholders  will be  held  on or  about  January  25,  2007.  In  order  for a
stockholder  to have a proposal  included  in the proxy  statement  for the 2006
annual stockholders'  meeting, the proposal must comply with both the procedures
identified by Rule 14a-8 under the Securities  Exchange Act of 1934, as amended,
(the "Exchange Act"),  and be received in writing by Alfacell's  Secretary on or
before 5:00 P.M.  Eastern Standard Time on August 18, 2006. Such a proposal will
be considered at the 2006 annual stockholders' meeting.

      In the event a stockholder does not meet the August 18, 2005 deadline, the
stockholder  can still give  notice of a proposal  to be  presented  at the 2006
annual stockholders' meeting until October 27, 2006, however, such proposal will
not be included in the proxy materials relating to such meeting. Such a proposal
will be considered timely within Rule 14a-4(c) and may be considered at the 2006
annual stockholders' meeting if it complies with Rule 14a-8.


                                       20


      Any proposal  received after November 1, 2006 will be considered  untimely
within  14a-4(c) of the Exchange Act and the persons named in the proxy for such
meeting may  exercise  their  discretionary  voting  power with  respect to such
proposal.

                                     GENERAL

      The  expenses  of  preparing  and  mailing  this proxy  statement  and the
accompanying proxy card and the cost of solicitation of proxies, if any, will be
borne by Alfacell. In addition to the use of mailings,  proxies may be solicited
by personal interview,  telephone and telegraph, and by directors,  officers and
regular employees of Alfacell without special compensation  therefore.  Alfacell
expects to  reimburse  banks,  brokers and other  persons  for their  reasonable
out-of-pocket  expenses in handling  proxy  materials for  beneficial  owners of
Alfacell's Common Stock.

      Unless contrary  instructions  are indicated on the proxy card, all shares
of  Common  Stock  represented  by  valid  proxies  received  pursuant  to  this
solicitation  (and not  revoked  before they are voted) will be voted FOR all of
the proposals described in this proxy statement.

                                  OTHER MATTERS

      The Board of Directors  knows of no other matters to be brought before the
Annual Meeting.  If matters other than the foregoing  should arise at the Annual
Meeting,  it is intended that the shares represented by proxies will be voted in
accordance  with the  judgment  of the persons  named in the proxy card.  Please
complete, sign and date the enclosed proxy card, which is revocable as described
herein, and mail it promptly in the enclosed postage-paid envelope.

                                  By Order of the Board of Directors,


                                  /s/ Kuslima Shogen
                                  ------------------
                                  Kuslima Shogen
                                  Chief Executive Officer, Chairman of the Board

Dated: December 16, 2005


                                       21


                              ALFACELL CORPORATION
                                      PROXY
                                  COMMON STOCK

                        ANNUAL MEETING: JANUARY 19, 2006
           THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

      Kuslima Shogen, as proxy, is hereby authorized to represent and to vote as
designated  below and on the reverse side upon the following  proposals,  and in
the  discretion of the proxies on such other matters as may properly come before
the Annual  Meeting of  Stockholders  of Alfacell  Corporation to be held at the
Somerset  Marriott Hotel,  110 Davidson  Avenue,  Somerset,  New Jersey 08873 on
Thursday,  January 19,  2005 at 2:00 p.m.  local  time,  or any  adjournment(s),
postponement(s) or other delay(s) thereof (the "Annual Meeting"),  all shares of
common  stock of  Alfacell to which the  undersigned  is entitled to vote at the
Annual Meeting.  The following  proposals are more fully described in the Notice
of Annual Meeting and Proxy  Statement for the Annual Meeting dated December 16,
2005 (receipt of which is hereby acknowledged).

      UNLESS OTHERWISE DIRECTED,  THIS PROXY WILL BE VOTED "FOR" THE ELECTION OF
ALL OF THE NOMINEES LISTED IN PROPOSAL 1 AND "FOR" PROPOSAL 2 AND WILL BE VOTED,
EITHER FOR OR AGAINST,  AT THE DISCRETION OF THE PROXIES,  ON SUCH OTHER MATTERS
AS MAY  PROPERLY  COME  BEFORE  THE  ANNUAL  MEETING.  THE  BOARD  OF  DIRECTORS
RECOMMENDS THAT STOCKHOLDERS VOTE "FOR" PROPOSALS 1 AND 2.

(Continued and to be dated and signed on the reverse side.)

                                                      ALFACELL CORPORATION
                                                      225 BELLEVILLE AVENUE
                                                      BLOOMFIELD, NJ 07003

--------------------------------------------------------------------------------

1.   To elect seven (7)    FOR all nominees |_|    WITHHOLD AUTHORITY  |_|
     directors             listed below            for all nominees listed below

     FOR ALL EXCEPT  |_|
     those nominees that I have listed below

      Nominees: Kuslima Shogen, John P. Brancaccio, Stephen K. Carter, Donald R.
Conklin, James J. Loughlin, David Sidransky and Paul M. Weiss (INSTRUCTIONS:  TO
WITHHOLD  AUTHORITY TO VOTE FOR ANY INDIVIDUAL  NOMINEE,  MARK THE "FOR ALL
EXCEPT" BOX AND WRITE THAT NOMINEE'S NAME IN THE SPACE PROVIDED BELOW.)

      Exceptions:_______________________________________________________________

2.    To ratify  the  appointment  of J.H.  Cohn LLP as  Alfacell's  independent
      registered  public  accounting  firm for the fiscal  year  ending July 31,
      2006.

         FOR      |_|               AGAINST    |_|             ABSTAIN    |_|

3.    To transact  such other  business as may  properly  come before the Annual
      Meeting.

                                        PLEASE  CHECK  THIS BOX IF YOU EXPECT TO
                                        ATTEND THE ANNUAL MEETING IN PERSON. |_|

                                        (Please  sign exactly as name appears to
                                        the left, date and return. If shares are
                                        held by joint tenants, both should sign.
                                        When signing as an  attorney,  executor,
                                        administrator,   trustee  or   guardian,
                                        please  give  full  title as such.  If a
                                        corporation,   please   sign   in   full
                                        corporate  name by  president  or  other
                                        authorized  officer.  If a  partnership,
                                        please  sign  in  partnership   name  by
                                        authorized person.)


                                        Please Date: ___________________________


                                        Sign Here: _____________________________


                                        ________________________________________
                                         Additional Signature (if held jointly)

                                   Votes must be indicated in Black or Blue ink.

                PLEASE SIGN AND DATE AND RETURN YOUR PROXY TODAY


                                       22