FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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(Print or Type Responses)

1. Name and Address of Reporting Person *   ARTAL INTERNATIONAL SCA 2. Date of Event Requiring Statement (Month/Day/Year) 03/31/2012 3. Issuer Name and Ticker or Trading Symbol LEXICON PHARMACEUTICALS, INC./DE [LXRX] (Last) (First) (Middle) 10-12 AVENUE PASTEUR 4. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director __X__ 10% Owner _____ Officer (give title below) _____ Other (specify below) 5. If Amendment, Date Original Filed(Month/Day/Year) (Street) LUXEMBOURG, N4 L-2310 6. Individual or Joint/Group Filing(Check Applicable Line) ___ Form filed by One Reporting Person _X_ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Beneficially Owned

1.Title of Security (Instr. 4) 2. Amount of Securities Beneficially Owned (Instr. 4) 3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 4. Nature of Indirect Beneficial Ownership (Instr. 5) Common Stock 250,372,135 I See Footnotes (1) (2)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.			SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
ARTAL INTERNATIONAL SCA 10-12 AVENUE PASTEUR LUXEMBOURG, N4 L-2310	  X	  X	Â	Â
Artal International Management S.A. 10-12 AVENUE PASTEUR LUXEMBOURG, N4 L-2310	  X	  X	Â	Â
ARTAL GROUP S A 10-12 AVENUE PASTEUR LUXEMBOURG, N4 L-2310	  X	  X	Â	Â
WESTEND SA 10-12 AVENUE PASTEUR LUXEMBOURG, N4 L-2310	  X	  X	Â	Â
Stichting Administratiekantoor Westend DE BOELELAAN 7, AMSTERDAM, P7 NL-1083 HJ	  X	  X	Â	Â
Minne Pascal PLACE STE. GUDULE, 19 BRUXELLES, C9 B-1000	  X	  X	Â	Â

Signatures

/s/ Anne Goffard, Managing Director for ARTAL INTERNATIONAL MANAGEMENT S.A., managing partner for ARTAL INTERNATIONAL S.C.A.		04/10/2012
**Signature of Reporting Person		Date
/s/ Anne Goffard, Managing Director for ARTAL INTERNATIONAL MANAGEMENT S.A.		04/10/2012
**Signature of Reporting Person		Date
/s/ Anne Goffard, Authorized Person for ARTAL GROUP S.A.		04/10/2012
**Signature of Reporting Person		Date
/s/ Pascal Minne, Director for WESTEND S.A.		04/10/2012
**Signature of Reporting Person		Date
/s/ Pascal Minne, Sole Member of the Board for STICHTING ADMINISTRATIEKANTOOR WESTEND		04/10/2012
**Signature of Reporting Person		Date
/s/ Pascal Minne		04/10/2012
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 5(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	244,818,843 of the reported shares of Issuer common stock are owned directly by Invus, L.P. and 5,553,292 of the reported shares of Issuer common stock are owned directly by Invus Public Equities, L.P. Invus Advisors, L.L.C. is the general partner of Invus, L.P., and Invus Public Equities Advisors, LLC is the general partner of Invus Public Equities, L.P. Artal International S.C.A. is the managing member of each of Invus Advisors, L.L.C. and Invus Public Equities Advisors, LLC. Artal International Management S.A. is the general partner of Artal International S.C.A., which is a wholly owned subsidiary of Artal Group S.A., which is a wholly owned subsidiary of Westend S.A., which is a wholly owned subsidiary of Stichting Administratiekantoor Westend (the "Stichting"). (Continued in Footnote 2)
(2)	Mr. Pascal Minne is the sole member of the board of the Stichting. Accordingly, each of Artal International S.C.A., Artal International Management S.A., Artal Group S.A., Westend S.A., the Stichting and Mr. Minne may be deemed to be indirect beneficial owners of the reported securities. Each of Artal International S.C.A., Artal International Management S.A., Artal Group S.A., Westend S.A., the Stichting and Mr. Minne disclaims beneficial ownership of such securities, except to the extent of its or his pecuniary interest therein.
  Remarks: For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, Artal International S.C.A., Artal International Management S.A., Artal Group S.A., Westend S.A., the Stichting and Mr. Minne may be deemed to be directors by deputization of the Issuer by virtue of Invus, L.P.'s right to designate certain members of the Issuer's board of directors pursuant to a stockholders' agreement between the Issuer and Invus, L.P.

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