Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
Polack Axel
   2. Issuer Name and Ticker or Trading Symbol
bluebird bio, Inc. [BLUE] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
TVM V LIFE SCIENCE VENTURES GMBH & CO., MAXIMILIANSTRASSE 35, ENTRANCE C		 3. Date of Earliest Transaction (Month/Day/Year)
06/24/2013
(Street)

MUNICH, 2M 80539		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 06/24/2013   C   2,254,357 (1) A $ 0 2,254,357 I See footnote (2)

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Series A-1 Convertible Preferred Stock (3) 06/24/2013   C     6,169,117   (3)   (3) Common Stock 325,255 (3) 0 I See footnote (2)
Series A-2 Convertible Preferred Stock (3) 06/24/2013   C     11,835,834   (3)   (3) Common Stock 624,021 (3) 0 I See footnote (2)
Series B Convertible Preferred Stock (3) 06/24/2013   C     17,749,014   (3)   (3) Common Stock 935,783 (3) 0 I See footnote (2)
Series C Convertible Preferred Stock (3) 06/24/2013   C     3,994,248   (3)   (3) Common Stock 210,589 (3) 0 I See footnote (2)
Series D Convertible Preferred Stock (3) 06/24/2013   C     3,010,234   (3)   (3) Common Stock 158,709 (3) 0 I See footnote (2)
Warrant to Purchase Series A-1 Stock (right to buy) $ 0.6619 06/24/2013   J(4)     660,982   (5) 11/16/2015 Series A-1 Convertible Preferred Stock 660,982 $ 0 0 I See footnote (2)
Warrant to Purchase Common Stock (right to buy) $ 12.55 06/24/2013   J(4)   34,849     (5) 11/16/2015 Common Stock 34,849 $ 0 34,849 I See footnote (2)
Warrant to Purchase Series A-1 Stock (right to buy) $ 0.6619 06/24/2013   J(4)     440,650   (5) 10/26/2016 Series A-1 Convertible Preferred Stock 440,650 $ 0 0 I See footnote (2)
Warrant to Purchase Common Stock (right to buy) $ 12.55 06/24/2013   J(4)   23,232     (5) 10/26/2016 Common Stock 23,232 $ 0 23,232 I See footnote (2)
Warrant to Purchase Series A-1 Stock (right to buy) $ 0.6619 06/24/2013   J(4)     1,038,674   (5) 05/03/2017 Series A-1 Convertible Preferred Stock 1,038,674 $ 0 0 I See footnote (2)
Warrant to Purchase Common Stock (right to buy) $ 12.55 06/24/2013   J(4)   54,760     (5) 05/03/2017 Common Stock 54,760 $ 0 54,760 I See footnote (2)
Warrant to Purchase Series A-1 Stock (right to buy) $ 0.6619 06/24/2013   J(4)     236,062   (5) 08/28/2018 Series A-1 Convertible Preferred Stock 236,062 $ 0 0 I See footnote (2)
Warrant to Purchase Common Stock (right to buy) $ 12.55 06/24/2013   J(4)   12,445     (5) 08/28/2018 Common Stock 12,445 $ 0 12,445 I See footnote (2)
Warrant to Purchase Series A-1 Stock (right to buy) $ 0.6619 06/24/2013   J(4)     236,062   (5) 12/18/2018 Series A-1 Convertible Preferred Stock 236,062 $ 0 0 I See footnote (2)
Warrant to Purchase Common Stock (right to buy) $ 12.55 06/24/2013   J(4)   12,445     (5) 12/18/2018 Common Stock 12,445 $ 0 12,445 I See footnote (2)
Warrant to Purchase Series A-1 Stock (right to buy) $ 0.6619 06/24/2013   J(4)     462,681   (5) 04/15/2019 Series A-1 Convertible Preferred Stock 462,681 $ 0 0 I See footnote (2)
Warrant to Purchase Common Stock (right to buy) $ 12.55 06/24/2013   J(4)   24,393     (5) 04/15/2019 Common Stock 24,393 $ 0 24,393 I See footnote (2)
Warrant to Purchase Series B Stock (right to buy) $ 0.3262 06/24/2013   J(6)     287,400   (5) 04/15/2019 Series B Convertible Preferred Stock 287,400 $ 0 0 I See footnote (2)
Warrant to Purchase Common Stock (right to buy) $ 6.19 06/24/2013   J(6)   15,152     (5) 04/15/2019 Common Stock 15,152 $ 0 15,152 I See footnote (2)

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
Polack Axel
TVM V LIFE SCIENCE VENTURES GMBH & CO.
MAXIMILIANSTRASSE 35, ENTRANCE C
MUNICH, 2M 80539		   X      

Signatures

 /s/ Linda C. Bain, Attorney-in-Fact   06/26/2013
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Represents the total number of shares received upon conversion of shares of the Issuer's Series A-1 Convertible Preferred Stock (the "Series A-1 Shares"), Series A-2 Convertible Preferred Stock (the "Series A-2 Shares"), Series B Convertible Preferred Stock (the "Series B Shares"), Series C Convertible Preferred Stock (the "Series C Shares") and Series D Convertible Preferred Stock (the "Series D Shares" and together with the Series A-1 Shares, the Series A-2 Shares, the Series B Shares and the Series C Shares, collectively, the "Preferred Shares").
(2) The securities are held directly by TVM V Life Science Ventures GmbH & Co. KG. ("TVM V"). The Reporting Person is an authorized officer of TVM V's general partner, TVM Capital GmbH, and disclaims beneficial ownership of all shares held by the foregoing entities except to the extent of his pecuniary interest therein.
(3) Effective upon the closing of the Issuer's initial public offering of its Common Stock, each Preferred Share automatically converted at a ratio of 18.967-to-one into the number of shares of Common Stock shown in column 7. The Preferred Shares had no expiration date.
(4) Upon completion of the Issuer's initial public offering, the warrant to purchase shares of Series A-1 Preferred Stock automatically converted on an 18.967-for-one basis into a warrant to purchase shares of Common Stock. Disposition of the Warrant to Purchase Series A-1 Preferred Stock and acquisition of the Warrant to Purchase Common Stock is listed solely for the purpose of reporting such conversion of the shares underlying the security.
(5) This warrant is immediately exercisable.
(6) Upon completion of the Issuer's initial public offering, the warrant to purchase shares of Series B Preferred Stock automatically converted on an 18.967-for-one basis into a warrant to purchase shares of Common Stock. Disposition of the Warrant to Purchase Series B Preferred Stock and acquisition of the Warrant to Purchase Common Stock is listed solely for the purpose of reporting such conversion of the shares underlying the security.

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