Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
WINGER DENNIS L
   2. Issuer Name and Ticker or Trading Symbol
APPLERA CORP [ABI/CRA] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
Senior Vice President and CFO
(Last)
(First)
(Middle)
APPLERA CORPORATION, 301 MERRITT 7		 3. Date of Earliest Transaction (Month/Day/Year)
05/03/2007
(Street)

NORWALK, CT 06851-1070		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Applied Biosystems Group Common Stock 05/03/2007   M   12,200 A $ 17.1149 79,501.2555 D  
Applied Biosystems Group Common Stock 05/03/2007   S(1)   61 D $ 31.02 79,440.2555 D  
Applied Biosystems Group Common Stock 05/03/2007   S(1)   305 D $ 31.01 79,135.2555 D  
Applied Biosystems Group Common Stock 05/03/2007   S(1)   305 D $ 31 78,830.2555 D  
Applied Biosystems Group Common Stock 05/03/2007   S(1)   487 D $ 30.99 78,343.2555 D  
Applied Biosystems Group Common Stock 05/03/2007   S(1)   61 D $ 30.98 78,282.2555 D  
Applied Biosystems Group Common Stock 05/03/2007   S(1)   426 D $ 30.97 77,856.2555 D  
Applied Biosystems Group Common Stock 05/03/2007   S(1)   548 D $ 30.96 77,308.2555 D  
Applied Biosystems Group Common Stock 05/03/2007   S(1)   183 D $ 30.95 77,125.2555 D  
Applied Biosystems Group Common Stock 05/03/2007   S(1)   305 D $ 30.94 76,820.2555 D  
Applied Biosystems Group Common Stock 05/03/2007   S(1)   366 D $ 30.93 76,454.2555 D  
Applied Biosystems Group Common Stock 05/03/2007   S(1)   244 D $ 30.92 76,210.2555 D  
Applied Biosystems Group Common Stock 05/03/2007   S(1)   304 D $ 30.91 75,906.2555 D  
Applied Biosystems Group Common Stock 05/03/2007   S(1)   184 D $ 30.9 75,722.2555 D  
Applied Biosystems Group Common Stock 05/03/2007   S(1)   183 D $ 30.89 75,539.2555 D  
Applied Biosystems Group Common Stock 05/03/2007   S(1)   184 D $ 30.88 75,355.2555 D  
Applied Biosystems Group Common Stock 05/03/2007   S(1)   244 D $ 30.87 75,111.2555 D  
Applied Biosystems Group Common Stock 05/03/2007   S(1)   181 D $ 30.86 74,930.2555 D  
Applied Biosystems Group Common Stock 05/03/2007   S(1)   61 D $ 30.85 74,869.2555 D  
Applied Biosystems Group Common Stock 05/03/2007   S(1)   365 D $ 30.84 74,504.2555 D  
Applied Biosystems Group Common Stock 05/03/2007   S(1)   121 D $ 30.83 74,383.2555 D  
Applied Biosystems Group Common Stock 05/03/2007   S(1)   121 D $ 30.82 74,262.2555 D  
Applied Biosystems Group Common Stock 05/03/2007   S(1)   305 D $ 30.81 73,957.2555 D  
Applied Biosystems Group Common Stock 05/03/2007   S(1)   122 D $ 30.8 73,835.2555 D  
Applied Biosystems Group Common Stock 05/03/2007   S(1)   305 D $ 30.79 73,530.2555 D  
Applied Biosystems Group Common Stock 05/03/2007   S(1)   243 D $ 30.78 73,287.2555 D  
Applied Biosystems Group Common Stock 05/03/2007   S(1)   61 D $ 30.76 73,226.2555 D  
Applied Biosystems Group Common Stock 05/03/2007   S(1)   61 D $ 30.74 73,165.2555 D  
Applied Biosystems Group Common Stock 05/03/2007   S(1)   62 D $ 30.73 73,103.2555 D  
Applied Biosystems Group Common Stock 05/03/2007   S(1)   61 D $ 30.72 73,042.2555 D  

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Applied Biosystems Group Employee Stock Options-Right to Buy $ 17.1149 05/03/2007   M     12,200 02/06/2002 06/26/2007 Applied Biosystems Group Common Stock 12,200 $ 0 22,400 D  
Celera Group Employee Stock Options-Right to Buy $ 6.9774 05/03/2007   M     4,800 09/25/2001 09/25/2007 Celera Group Common Stock 4,800 $ 0 2,625 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
WINGER DENNIS L
APPLERA CORPORATION
301 MERRITT 7
NORWALK, CT 06851-1070		       Senior Vice President and CFO  

Signatures

 /s/ Thomas P. Livingston, Attorney-In-Fact for Dennis L. Winger   05/07/2007
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Reflects sale by independent third-party administrator under the issuer's Insider Diversification Program.
 
Remarks:
This is the first of three forms being filed by the reporting person on May 7, 2007.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.