FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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(Print or Type Responses)

1. Name and Address of Reporting Person * WHITE TONY L   2. Issuer Name and Ticker or Trading Symbol APPLIED BIOSYSTEMS INC. [ABI] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director _____ 10% Owner __X__ Officer (give title below) _____ Other (specify below) Chairman and CEO (Last) (First) (Middle) APPLIED BIOSYSTEMS INC., 301 MERRITT 7 3. Date of Earliest Transaction (Month/Day/Year) 11/17/2008 (Street) NORWALK, CT 06851-1070 4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Applied Biosystems Group Common Stock 11/17/2008   M   300,000 A $ 27.1875 1,324,850.6816 D   Applied Biosystems Group Common Stock 11/17/2008   M   84,400 A $ 28.2343 1,409,250.6816 D   Applied Biosystems Group Common Stock 11/17/2008   M   84,400 A $ 28.2343 1,493,650.6816 D   Applied Biosystems Group Common Stock 11/17/2008   M   10,815 A $ 25.575 1,504,465.6816 D   Applied Biosystems Group Common Stock 11/17/2008   S   455,610 D $ 29.327 (1) 1,048,855.6816 D   Applied Biosystems Group Common Stock               75,000 I By Elizabeth Ann White Business Interests, LLLP (2) Applied Biosystems Group Common Stock               161,760 I By Tony Lee White 2007 Grantor Retained Annuity Trust (3)

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Applied Biosystems Group Employee Stock Options-Right to Buy

$ 27.1875

11/17/2008

M

300,000

05/13/2003

05/13/2009

Applied Biosystems Group Common Stock

300,000

$ 0

0

D

Applied Biosystems Group Employee Stock Options-Right to Buy

$ 28.2343

11/17/2008

M

84,400

06/17/2002

06/17/2009

Applied Biosystems Group Common Stock

84,400

$ 0

0

D

Applied Biosystems Group Employee Stock Options-Right to Buy

$ 28.2343

11/17/2008

M

84,400

11/30/2002

06/17/2009

Applied Biosystems Group Common Stock

84,400

$ 0

0

D

Applied Biosystems Group Employee Stock Options-Right to Buy

$ 25.575

11/17/2008

M

10,815

(4)

03/26/2011

Applied Biosystems Group Common Stock

10,815

$ 0

0

D

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
WHITE TONY L APPLIED BIOSYSTEMS INC. 301 MERRITT 7 NORWALK, CT 06851-1070	X		Chairman and CEO

Signatures

/s/ Thomas P. Livingston, Attorney-in-Fact for Tony L. White		11/19/2008
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	The price reported is the weighted average sale price in open market transactions at prices ranging from $29.18 to $29.46. The reporting person undertakes to provide upon request by the Securities and Exchange Commission staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price.
(2)	Elizabeth Ann White Business Interests, LLLP, is a family limited partnership (the "FLP"). The reporting person's adult daughter is the sole general partner of the FLP, and the reporting person's wife and a grantor retained annuity trust established by the reporting person are currently the sole limited partners of the FLP.
(3)	The reporting person's wife is the sole trustee of the Tony Lee White 2007 Grantor Retained Annuity Trust.
(4)	These options originally became exercisable in four equal annual installments, commencing March 26, 2002 . Effective January 20, 2005, the vesting of all of these options was accelerated. However, shares received upon the exercise of accelerated options were subject to a restriction on transfer (covering sales, gifts, pledges, and any other method of disposition) that remained in effect for some of the shares until March 26, 2005.

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