UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549



                                  SCHEDULE 13G

                   Under the Securities Exchange Act of 1934*

                                (Amendment No. 6)



                               Quidel Corporation
                               ------------------
                                (Name of Issuer)

                         Common Stock, $0.001 par value
                         ------------------------------
                         (Title of Class of Securities)

                                    74838J101
                                    ---------
                                 (CUSIP Number)

                                December 31, 2008
                                -----------------
             (Date of Event Which Requires Filing of this Statement)

           Check the appropriate box to designate the rule pursuant to
                         which this Schedule is filed:

                                [ ] Rule 13d-1(b)
                                [X] Rule 13d-1(c)
                                [ ] Rule 13d-1(d)

  *The remainder of this cover page shall be filled out for a reporting person's
  initial filing on this form with respect to the subject class of securities,
  and for any subsequent amendment containing information which would alter the
  disclosures provided in a prior cover page.

  The information required on the remainder of this cover page shall not be
  deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
  Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
  the Act but shall be subject to all other provisions of the Act (however, see
  the Notes).







-------------------------------                                -----------------
CUSIP No.  74838J101                     13G                   Page 2 of 8 Pages
-------------------------------                                -----------------

---------- ---------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Oracle Partners, L.P.
---------- ---------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                      (a) [ ]
                                                                      (b) [X]
---------- ---------------------------------------------------------------------
3          SEC USE ONLY
---------- ---------------------------------------------------------------------
4          CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware
-------------------- ------ ----------------------------------------------------
                     5      SOLE VOTING POWER

                            0
                     ------ ----------------------------------------------------
     NUMBER OF       6      SHARED VOTING POWER
      SHARES
   BENEFICIALLY             1,698,935
     OWNED BY
       EACH          ------ ----------------------------------------------------
     REPORTING       7      SOLE DISPOSITIVE POWER
      PERSON
       WITH                 0
                     ------ ----------------------------------------------------
                     8      SHARED DISPOSITIVE POWER

                            1,698,935
---------- ---------------------------------------------------------------------
9          AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           1,698,935
---------- ---------------------------------------------------------------------
10         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

           N/A
---------- ---------------------------------------------------------------------
11         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

           5.6%
---------- ---------------------------------------------------------------------
12         TYPE OF REPORTING PERSON*

           PN
---------- ---------------------------------------------------------------------






-------------------------------                                -----------------
CUSIP No.  74838J101                     13G                   Page 3 of 8 Pages
-------------------------------                                -----------------

---------- ---------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Oracle Associates, LLC
---------- ---------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                      (a) [ ]
                                                                      (b) [X]
---------- ---------------------------------------------------------------------
3          SEC USE ONLY
---------- ---------------------------------------------------------------------
4          CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware
-------------------- ------ ----------------------------------------------------
                     5      SOLE VOTING POWER

                            0
                     ------ ----------------------------------------------------
     NUMBER OF       6      SHARED VOTING POWER
      SHARES
   BENEFICIALLY             2,255,921
     OWNED BY
       EACH          ------ ----------------------------------------------------
     REPORTING       7      SOLE DISPOSITIVE POWER
      PERSON
       WITH                 0
                     ------ ----------------------------------------------------
                     8      SHARED DISPOSITIVE POWER

                            2,255,921
---------- ---------------------------------------------------------------------
9          AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           2,255,921
---------- ---------------------------------------------------------------------
10         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

           N/A
---------- ---------------------------------------------------------------------
11         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

           7.5%
---------- ---------------------------------------------------------------------
12         TYPE OF REPORTING PERSON*

           OO
---------- ---------------------------------------------------------------------






-------------------------------                                -----------------
CUSIP No.  74838J101                     13G                   Page 4 of 8 Pages
-------------------------------                                -----------------

---------- ---------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Larry N. Feinberg
---------- ---------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                      (a) [ ]
                                                                      (b) [X]
---------- ---------------------------------------------------------------------
3          SEC USE ONLY
---------- ---------------------------------------------------------------------
4          CITIZENSHIP OR PLACE OF ORGANIZATION

           United States
-------------------- ------ ----------------------------------------------------
                     5      SOLE VOTING POWER

                            40,000
                     ------ ----------------------------------------------------
     NUMBER OF       6      SHARED VOTING POWER
      SHARES
   BENEFICIALLY             2,829,795
     OWNED BY
       EACH          ------ ----------------------------------------------------
     REPORTING       7      SOLE DISPOSITIVE POWER
      PERSON
       WITH                 40,000
                     ------ ----------------------------------------------------
                     8      SHARED DISPOSITIVE POWER

                            2,829,795
---------- ---------------------------------------------------------------------
9          AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           2,869,795
---------- ---------------------------------------------------------------------
10         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

           N/A
---------- ---------------------------------------------------------------------
11         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

           9.5%
---------- ---------------------------------------------------------------------
12         TYPE OF REPORTING PERSON*

           IN
---------- ---------------------------------------------------------------------






This Amendment No. 6 to Schedule 13G (this "Amendment No. 6") is being filed
with respect to the Common Stock, par value $.001 ("Common Stock") of Quidel
Corporation, a Delaware corporation (the "Company"), to amend the Schedule 13G
filed on April 23, 2001, as previously amended by Amendment No. 1, filed on
February 14, 2002, by Amendment No. 2, filed on February 12, 2003, by Amendment
No. 3, filed on February 9, 2005, by Amendment No. 4, filed on February 7, 2006
and by Amendment No. 5, filed on February 15, 2008 (as so amended, the "Schedule
13G"), in accordance with the annual amendment requirements and to update
ownership information not previously reported through filings on Schedule 13G.
Capitalized terms used but not defined herein have the meaning ascribed thereto
in the Schedule 13G.

Item 2(a):     Name of Person Filing:
---------      ---------------------

     Item 2(a) of the Schedule 13G is hereby amended and restated as follows:

     This statement is filed by:

      (i) Oracle Partners, L.P., a Delaware limited partnership ("Oracle
          Partners"), with respect to shares of Common Stock directly owned by
          it;

     (ii) Oracle Associates, LLC, a Delaware limited liability company ("Oracle
          Associates"), which serves as the general partner of Oracle Partners
          and certain other investment funds and/or managed accounts (the
          "Domestic Funds"), with respect to shares of Common Stock directly
          owned by the Domestic Funds; and

    (iii) Mr. Larry N. Feinberg ("Mr. Feinberg"), who (A) serves as the senior
          managing member of Oracle Associates, (B) is the sole shareholder and
          president of Oracle Investment Management, Inc., a Delaware
          corporation, which serves as the investment manager and has investment
          discretion over the securities held by certain investment funds and/or
          managed accounts (together with the Domestic Funds, the "Funds"), (C)
          is the trustee of The Feinberg Family Foundation (the "Foundation"),
          and (D) is the trustee of certain trusts or the manager of certain
          trusts where a relative serves as trustee (the "Trusts"). Mr. Feinberg
          directly owns (individually and as trustee of the Foundation and
          certain of the Trusts) certain shares of Common Stock and may be
          deemed to indirectly beneficially own shares of Common Stock, by
          virtue of the foregoing relationships, directly owned by the Funds and
          certain of the Trusts.

     The foregoing persons are hereinafter sometimes collectively referred to as
the "Reporting  Persons." Any  disclosures  herein with respect to persons other
than the  Reporting  Persons are made on  information  and belief  after  making
inquiry to the appropriate party.

                                      -5-


Item 4:   Ownership:
------    ---------

     Item 4 of the Schedule 13G is hereby amended and restated as follows:

I.   Current Ownership.
     -----------------

The  beneficial  ownership of Common Stock by the Reporting  Persons,  as of the
date of this Amendment No. 6, is as follows:

A.   Oracle Partners, L.P.
     ---------------------
     (a) Amount beneficially owned: 1,698,935.
     (b) Percent of class: 5.6%. The percentages used herein and in the rest of
this Amendment No. 6, with the exception of Section II of this Item 4, are
calculated based upon a total of 30,093,433 shares of Common Stock issued and
outstanding as of April 22, 2009, as reported in the Company's Quarterly Report
on Form 10-Q for the period ended March 31, 2009.
     (c) Number of shares as to which such person has:
            (i)   Sole power to vote or direct the vote: -0-
            (ii)  Shared power to vote or direct the vote: 1,698,935
            (iii) Sole power to dispose or direct the disposition: -0-
            (iv)  Shared power to dispose or direct the disposition: 1,698,935

B.   Oracle Associates, LLC
     ----------------------
     (a) Amount beneficially owned: 2,255,921.
     (b) Percent of class: 7.5%.
     (c) Number of shares as to which such person has:
             (i)   Sole power to vote or direct the vote: -0-
             (ii)  Shared power to vote or direct the vote: 2,255,921
             (iii) Sole power to dispose or direct the disposition: -0-
             (iv)  Shared power to dispose or direct the disposition: 2,255,921

C.   Larry N. Feinberg
     -----------------
     (a) Amount beneficially owned: 2,869,795.
     (b) Percent of class: 9.5%.
     (c) Number of shares as to which such person has:
             (i)   Sole power to vote or direct the vote: 40,000
             (ii)  Shared power to vote or direct the vote: 2,829,795
             (iii) Sole power to dispose or direct the disposition: 40,000
             (iv)  Shared power to dispose or direct the disposition: 2,829,795

                                      -6-


II.  December 31, 2008 Ownership.
     ---------------------------

The beneficial ownership of Common Stock by the Reporting Persons, as of the
December 31, 2008, is as follows:

A.   Oracle Partners, L.P.
     ---------------------
     (a) Amount beneficially owned: 1,895,927.
     (b) Percent of class: 5.8%. The percentages used in this Section II of
Item 4 are calculated based upon a total of 32,547,651 shares of Common Stock
issued and outstanding as of October 22, 2008, as reported in the Company's
Quarterly Report on Form 10-Q for the period ended September 30, 2008.
     (c) Number of shares as to which such person has:
             (i)   Sole power to vote or direct the vote: -0-
             (ii)  Shared power to vote or direct the vote: 1,895,927
             (iii) Sole power to dispose or direct the disposition: -0-
             (iv)  Shared power to dispose or direct the disposition: 1,895,927

B.   Oracle Associates, LLC
     ----------------------
     (a) Amount beneficially owned: 2,442,413.
     (b) Percent of class: 7.5%.
     (c) Number of shares as to which such person has:
             (i)   Sole power to vote or direct the vote: -0-
             (ii)  Shared power to vote or direct the vote: 2,442,413
             (iii) Sole power to dispose or direct the disposition: -0-
             (iv)  Shared power to dispose or direct the disposition: 2,442,413

C.   Larry N. Feinberg
     -----------------
     (a) Amount beneficially owned: 2,514,964.
     (b) Percent of class: 7.7%.
     (c) Number of shares as to which such person has:
             (i)   Sole power to vote or direct the vote: -0-
             (ii)  Shared power to vote or direct the vote: 2,514,964
             (iii) Sole power to dispose or direct the disposition: -0-
             (iv)  Shared power to dispose or direct the disposition: 2,514,964

Item 10:  Certification:
-------   -------------

     Each of the Reporting Persons hereby makes the following certification:

     By signing below I certify that, to the best of my knowledge and belief,
the securities referred to above were not acquired and are not held for the
purpose of or with the effect of changing or influencing the control of the
issuer of the securities and were not acquired and are not held in connection
with or as a participant in any transaction having that purpose or effect.

              [THE REMAINDER OF THIS PAGE LEFT INTENTIONALLY BLANK]

                                      -7-










                                    SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.

DATED:  May 20, 2009



                                 /s/ Larry N. Feinberg
                                 -----------------------------------------------
                                 Larry N. Feinberg


                                 ORACLE ASSOCIATES, LLC


                                 By:    /s/ Larry N. Feinberg
                                        ----------------------------------------
                                        Name:   Larry N. Feinberg
                                        Title:  Senior Managing Member


                                 ORACLE PARTNERS, L.P.

                                 By:    Oracle Associates, LLC, its General
                                        Partner


                                 By:    /s/ Larry N. Feinberg
                                        ----------------------------------------
                                        Name:   Larry N. Feinberg
                                        Title:  Senior Managing Member



       [SIGNATURE PAGE TO AMENDMENT NO. 6 TO SCHEDULE 13G WITH RESPECT TO
                              QUIDEL CORPORATION]