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                            NEOSE TECHNOLOGIES, INC.
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                            Neose Technologies, Inc.




                                  [NEOSE LOGO]




                                 102 Witmer Road
                           Horsham, Pennsylvania 19044





April 27, 2001

Dear Stockholder:

         You are invited to attend the Annual Meeting of Stockholders of Neose
Technologies, Inc. on June 20, 2001. You will have the opportunity to ask
questions and make comments. Enclosed with this letter are your Notice of Annual
Meeting of Stockholders, Proxy Statement, Proxy voting card, and 2000 Annual
Report to Stockholders.

         At this year's meeting, you will be asked to elect eight directors to
serve a term of one year each and to increase the number of shares issuable
under our Amended and Restated 1995 Stock Option/Stock Issuance Plan.

         I hope that you attend the meeting. Whether or not you plan to be with
us, please sign, date, and return your voting card promptly in the enclosed
envelope.

Sincerely,

/s/ Stephen Roth

Stephen Roth
Chairman and Chief Executive Officer





                            Neose Technologies, Inc.




                                  [NEOSE LOGO]





                                 102 Witmer Road
                           Horsham, Pennsylvania 19044



                    Notice of Annual Meeting of Stockholders
                            to be held June 20, 2001


To the Stockholders of Neose Technologies, Inc.:

         The 2001 Annual Meeting of Stockholders will be held at our office at
102 Witmer Road, Horsham, Pennsylvania on Wednesday, June 20, 2001 at 1:00 p.m.
During the Annual Meeting, stockholders will be asked to:

1.       Elect eight directors to serve for a term of one year or until the
         election and qualification of their successors;

2.       Approve an amendment to our Amended and Restated 1995 Stock
         Option/Stock Issuance Plan to increase by 700,000 shares the number of
         shares issuable under the stock option plan; and

3.       Transact any other business properly brought before the Annual Meeting.

         If you are a stockholder as of April 23, 2001, you may vote at the
meeting. The date of mailing this Notice of Meeting and Proxy Statement is on or
about May 1, 2001.

By order of the Board of Directors

/s/ Stephen Roth

Stephen Roth
Chairman and Chief Executive Officer







                                 Proxy Statement

         This Proxy Statement and the accompanying proxy card are being mailed,
beginning on or about May 1, 2001, to owners of shares of common stock of Neose
Technologies, Inc. in connection with the solicitation of proxies by the Board
of Directors for our Annual Meeting of Stockholders. This proxy procedure is
necessary to permit all stockholders, many of whom are unable to attend the
Annual Meeting, to vote. The Board of Directors encourages you to read this
document thoroughly and to take this opportunity to vote on the matters to be
decided at the Annual Meeting.


                                    Contents



                                                                                                              
Questions and Answers.............................................................................................2
Proposal 1-- Election of Directors................................................................................6
Summary Compensation Table........................................................................................9
Employment Agreements.............................................................................................9
Option Grant Table...............................................................................................10
Aggregrated Fiscal Year-End Option Values........................................................................11
Report of the Compensation Committee.............................................................................11
Common Stock Performance Graph...................................................................................13
Report of the Audit Committee....................................................................................13
Section 16(a) Beneficial Ownership Reporting Compliance..........................................................14
Stock Ownership of our Directors, Executive Officers, and 5% Beneficial Owners...................................15
Certain Relationships and Related Transaction....................................................................16
Proposal 2-- Amendment to our Amended and Restated 1995 Stock Option/Stock Issuance Plan.........................17
Independent Certified Public Accountants.........................................................................23
Requirements for Advance Notification of Nominations and Stockholder Proposals...................................23






                                       1




                              Questions and Answers

Q.       What am I voting on?

A.       1.   The election of eight directors for a one-year term or until the
              election and qualification of their successors.
         2.   An amendment to our Amended and Restated 1995 Stock Option/Stock
              Issuance Plan to increase by 700,000 shares the number of shares
              issuable under the stock option plan.
         3.   Any other business that properly comes before the meeting for
              a vote.

Q.       Who is entitled to vote at the Annual Meeting, and how many votes do
         they have?

A.       Common stockholders of record at the close of business on April 23,
         2001 may vote at the Annual Meeting. Each share has one vote. There
         were 14,013,793 shares of common stock outstanding on April 23, 2001.
         From June 10, 2001 through June 20, 2001, you may inspect a list of
         stockholders eligible to vote. If you would like to inspect the list,
         please call A. Brian Davis, our Corporate Secretary, at (215) 441-5890
         to arrange a visit to our offices.

Q.       How do I vote?

A.       You must be present, or represented by proxy, at the Annual Meeting in
         order to vote your shares. Because many of our stockholders are unable
         to attend the Annual Meeting in person, we send proxy cards to all of
         our stockholders to enable them to be represented and to vote at the
         Annual Meeting.

Q.       What is a proxy?

A.       A proxy is a person you appoint to vote on your behalf. If you are
         unable to attend the Annual Meeting, we are seeking your appointment of
         proxies so that your shares of common stock may be voted. You must
         complete and return the enclosed proxy card to have your shares voted
         by proxy.

Q.       By completing and returning this proxy card, who am I designating as
         my proxy?

A.       You will be designating Stephen Roth, our Chairman and Chief Executive
         Officer, and Sherrill Neff, our President, Chief Operating Officer, and
         Chief Financial Officer, as your proxies. They may act together or
         individually on your behalf, and will have the authority to appoint a
         substitute to act as proxy.

Q.       How will my proxy vote my shares?

A.       Your proxy will vote according to the instructions on your proxy card.
         If you complete and return your proxy card but do not indicate your
         vote on business matters, your proxy will vote "FOR" Proposals 1 and 2.
         We do not intend to bring any other matter for a vote at the Annual
         Meeting, and we do not know of anyone else who intends to do so. Your
         proxies are authorized to vote on your behalf, however, using their
         best judgment, on any other business that properly comes before the
         Annual Meeting.

Q.       How do I vote using my proxy card?

A.       If you do not vote in person at the Annual Meeting, you may vote by
         mail by returning the enclosed proxy card to us. To vote by mail,
         simply mark, sign, and date the enclosed proxy card, and return it in
         the enclosed postage-paid envelope. Alternatively, you may deliver your
         proxy card to us in person, by facsimile, or by a courier.

                                       2




Q.       What if my shares are held in "street name"?

A.       If you hold your shares in "street name" through a broker or other
         nominee, you will receive separate instructions from the nominee
         describing how to vote your shares. If you do not give your broker or
         nominee specific instructions for either proposal, your broker is
         entitled to vote your shares in favor of each proposal. Shares
         represented by such "broker non-votes" will also be counted in
         determining whether there is a quorum.

Q.       How do I revoke my proxy?

A.       You may revoke your proxy at any time before your shares are voted at
         the Annual Meeting by:

         o  Notifying our Corporate Secretary, A. Brian Davis, in writing at
            102 Witmer Road, Horsham, PA 19044, that you are revoking your
            proxy;
         o  Executing a new proxy card; or
         o  Attending and voting by ballot at the Annual Meeting.

Q.       Is my vote confidential?

A.       Yes, only certain employees will have access to your proxy card. All
         comments remain confidential, unless you ask that your name be
         disclosed.

Q.       Who will count the votes?

A.       An officer of Neose Technologies, Inc. will act as the inspector of
         election and count the votes.

Q.       What constitutes a quorum?

A.       A majority of the outstanding shares, either present or represented by
         proxy, constitutes a quorum. As of April 23, 2001, there were
         14,013,793 shares of common stock issued, outstanding, and entitled to
         vote at the Annual Meeting. A quorum is necessary in order to conduct
         the Annual Meeting. If you choose to have your shares represented by
         proxy at the Annual Meeting, you will be considered part of the quorum.
         If a quorum is not present at the Annual Meeting, the stockholders
         present in person or by proxy may adjourn the meeting to a date when a
         quorum is present. If an adjournment is for more than 30 days or a new
         record date is fixed for the adjourned meeting, we will provide notice
         of the adjourned meeting to each stockholder of record entitled to vote
         at the meeting.

Q.       How will my vote be counted?

A.       For Proposal 1, the election of directors, the nominees will be elected
         by a plurality of the votes cast at the annual meeting. You may choose
         to vote, or withhold your vote, separately for each nominee. Votes that
         are withheld will have no effect on the results of the vote. Brokers
         that do not receive instructions are entitled to vote those shares for
         the election of the directors.

         For Proposal 2, an amendment to our Amended and Restated 1995 Stock
         Option/Stock Issuance Plan:

                                       3




         o   You may abstain, and your abstention will have the same effect as
             a vote against Proposal 2; and
         o   If you hold your shares through a broker in "street name" and you
             do not give instructions to your broker to vote your shares with
             respect to Proposal 2, your broker is entitled to vote those shares
             on the proposal to approve the amendment to our option plan. If
             your broker fails to vote your shares in this instance, there will
             be no effect on the vote because "broker non-votes" are not
             considered present at the meeting.

Q.       What percentage of our common shares do the directors and officers own?

A.       As of April 23, 2001, our directors and executive officers beneficially
         owned approximately 22.5% of our common shares. See the discussion
         under the heading "Stock Ownership of our Directors, Executive
         Officers, and 5% Beneficial Owners" on page 15 for more details.

Q.       Who is soliciting my proxy, how is it being solicited, and who pays
         the cost?

A.       Neose Technologies, Inc., on behalf of the Board of Directors, through
         its directors, officers, and employees, is soliciting proxies
         primarily by mail. In addition, proxies may also be solicited in
         person, by telephone, or facsimile. Morrow & Co., Inc., a proxy
         solicitation firm, will be assisting us for a fee of approximately
         $4,500, plus out-of-pocket expenses. We will pay the cost of
         soliciting proxies. We will also reimburse stockbrokers and other
         custodians, nominees, and fiduciaries for their reasonable
         out-of-pocket expenses for forwarding proxy and solicitation material
         to the owners of our common shares.

Q.       When are stockholder proposals for next year's Annual Meeting due?

A.       To be included in the mailing of the Notice of Annual Meeting of
         Stockholders, Proxy Statement, and Proxy voting card for next year's
         annual meeting, proposed stockholder proposals must be sent by
         December 29, 2001 to our Corporate Secretary, at 102 Witmer Road,
         Horsham, PA 19044. Proposed stockholder proposals for next year's
         Annual Meeting that are not intended for inclusion in the Notice of
         Annual Meeting of Stockholders, Proxy Statement, and Proxy voting card
         must be received by February 1, 2002 by our Corporate Secretary. You
         should submit any proposal by a method that permits you to prove the
         date of delivery to us. See the discussion under the heading
         "Requirements for Advance Notification of Nominations and Stockholder
         Proposals" on page 22 for information regarding certain procedures
         with respect to stockholder proposals and nominations of directors.


                                       4






Q.       Who are the Company's Independent Public Accountants, and will they be
         represented at the Annual Meeting?

A.       Arthur Andersen LLP has served as our independent public accountants
         and auditors since 1994, and we have selected them to serve as our
         auditor for 2001. We expect a representative of Arthur Andersen LLP to
         be present at the Annual Meeting. The representative will have an
         opportunity to make a statement, if he or she desires, and be available
         to answer questions.

Q.       How may I obtain a copy of the Company's Form 10-K?

A.       You may request a copy of our Annual Report on Form 10-K for the year
         ended December 31, 2000, by writing to our Corporate Secretary at 102
         Witmer Road, Horsham, Pennsylvania, 19044 or via e-mail at
         info@neose.com.



                                       5






                       Proposal 1 -- Election of Directors

         The Board of Directors has eight members. Each member has been
nominated for re-election, and has agreed, if elected, to serve a one-year term
or until the election and qualification of his successor. If any nominee is
unable to stand for election, which circumstance we do not anticipate, the Board
may provide for a lesser number of directors or designate a substitute. In the
latter event, shares represented by proxies may be voted for a substitute
nominee.

         If a quorum is present at the Annual Meeting, then a plurality of all
votes cast at the meeting will be sufficient to elect a director. There is no
cumulative voting in the election of directors.

         The Board of Directors recommends a vote "FOR" each of the nominees.

         Stephen A. Roth, 58, has served on our Board since 1989, and as
Chairman and Chief Executive Officer since August 1994. Dr. Roth co-founded
Neose, and from 1992 until August 1994, he served as Senior Vice President,
Research and Development and Chief Scientific Officer. Dr. Roth was on the
faculty of the University of Pennsylvania from 1980 to 1994, and was Chairman of
Biology from 1982 to 1987. Dr. Roth received his A.B. in biology from The Johns
Hopkins University, and his Ph.D. in developmental biology from the Case Western
Reserve University. He completed his post-doctorate training in carbohydrate
chemistry at The Johns Hopkins University.

         P. Sherrill Neff, 49, has served on our Board since 1994, as President
and Chief Financial Officer since December 1994, and as Chief Operating Officer
since April 2000. From 1993 to December 1994, Mr. Neff was Senior Vice
President, Corporate Development, at U.S. Healthcare, Inc., a managed healthcare
company. From 1984 to 1993, he worked at Alex. Brown & Sons Incorporated, an
investment banking firm, where he held a variety of positions, most recently as
Managing Director and Co-Head of the Financial Services Group. Mr. Neff is a
director of Resource America, Inc., a publicly held energy and real estate
finance company. Mr. Neff is also on the board of directors of the Pennsylvania
Biotechnology Association, the University City Science Center, and the
Biotechnology Institute. Mr. Neff received his B.A. in religion from Wesleyan
University, and his J.D. from the University of Michigan Law School.

         William F. Hamilton, 63, has served on our Board since 1991. Dr.
Hamilton has served on the University of Pennsylvania faculty since 1967, and is
the Landau Professor of Management and Technology, and Director of the Jerome
Fisher Program in Management and Technology at The Wharton School and the School
of Engineering and Applied Science. He serves as a director of the following
publicly-held companies: Digital Lightwave, Inc., a manufacturer of
telecommunications test equipment; Hunt Manufacturing Co., a manufacturer of art
and office supplies; and Marlton Technologies, Inc., a trade show supply
company. Dr. Hamilton received his B.S. and his M.S. in chemical engineering and
his M.B.A. from the University of Pennsylvania, and his Ph.D. in applied
economics from the London School of Economics.

         Douglas J. MacMaster, Jr., 70, has served on our Board since 1993. Mr.
MacMaster served as Senior Vice President of Merck & Co., Inc. from 1988 to
1992, where he was responsible for worldwide chemical and pharmaceutical
manufacturing, the Agvet Division, and the Specialty Chemicals Group. From 1985
to 1988, Mr. MacMaster was President of the Merck Sharp Dohme Division of Merck.
Mr. MacMaster serves as a director of the following publicly held companies:
Stratton Mutual Funds, and Martek Biosciences Corp., a biological products
manufacturing company. He received his B.A. from St. Francis Xavier University,
and his J.D. from Boston College Law School.


                                       6




         Mark H. Rachesky, 42, has served on our Board since 1999. Dr. Rachesky
is the founder and President of MHR Fund Management LLC and affiliates,
investment managers of various private investment funds that invest in
inefficient market sectors, including special situation equities and distressed
investments. From 1990 through June 1996, Dr. Rachesky was employed by Carl C.
Icahn, initially as a senior investment officer and for the last three years as
sole Managing Director of Icahn Holding Corporation, and acting chief investment
advisor. Dr. Rachesky is currently on the board of directors of Samsonite
Corporation and Keryx Biopharmaceuticals, Inc. Dr. Rachesky is a graduate of
Stanford University School of Medicine, and Stanford University School of
Business. Dr. Rachesky graduated from the University of Pennsylvania with a
major in Molecular Aspects of Cancer.

         Lindsay A. Rosenwald, 46, has served on our Board since 1989, and
served as our Chairman until August 1994. He is an investment banker, a venture
capitalist, and a fund manager. Dr. Rosenwald has served as Chairman of
Paramount Capital, Inc., an NASD member broker dealer, since 1992; Chairman of
Paramount Capital Investments, LLC, a venture capital firm, since 1996; and
Chairman of Paramount Capital Asset Management, Inc., which manages the
investment of several funds specializing in the biotechnology sector, since
1994. He is a director of Interneuron Pharmaceuticals, Inc. and Keryx
Biopharmaceuticals, Inc., each of which is a publicly-held biotechnology
company. Dr. Rosenwald received his B.S. in finance from Pennsylvania State
University, and his M.D. from Temple University School of Medicine.

         Lowell E. Sears, 50, has served on our Board since 1994. He has been a
private investor involved in portfolio management and life sciences venture
capital since April 1994. From 1988 until April 1994, Mr. Sears was Chief
Financial Officer of Amgen Inc., a pharmaceutical company, and from 1992 until
1994, he also served as Senior Vice President responsible for the Asia-Pacific
region. Mr. Sears is a director of Techne Corp. and Dendreon Corporation, each
of which is a publicly-held biotechnology company. Mr. Sears received his B.A.
in economics from Claremont McKenna College, and his M.B.A. from Stanford
University.

         Jerry A. Weisbach, 67, has served on our Board since 1993. From 1988 to
1994, he served as Director of Technology Transfer and Adjunct Professor at The
Rockefeller University. Dr. Weisbach served as Vice President of Warner-Lambert
Company from 1981 to 1987 and President, Pharmaceutical Research Division from
1979 to 1987, where he was responsible for all pharmaceutical research and
development activities. Dr. Weisbach serves as a director of Inkine
Pharmaceutical Company, a publicly-held biotechnology company. Dr. Weisbach
received his B.S. in chemistry from Brooklyn College, and his M.A. and his Ph.D.
in chemistry from Harvard University.

How are directors nominated?

         The Board of Directors has nominated each current director to stand for
re-election. See the discussion under the heading "Requirements for Advance
Notification of Nominations and Stockholder Proposals" on page 22 for
information about procedures for stockholder nomination of directors.

How are directors compensated?

         Directors who are also Neose employees receive no additional
compensation for serving as a director. Non-employee directors receive:

         o   A $14,000 annual retainer, which may be applied, in whole or in
             part, toward the acquisition of an option to purchase shares of
             our common stock;

                                       7




         o   Reimbursement for reasonable travel expenses incurred for their
             attendance at meetings of the Board of Directors;
         o   Consulting fees of $2,000 per day of additional service; and
         o   Upon initial election or appointment to the Board of Directors, an
             option to purchase 16,666 shares of common stock and upon
             re-election to the Board of Directors, an option to purchase
             10,000 shares of common stock. Each automatic option grant has
             an exercise price equal to the fair market value on the date
             of grant. Each automatic grant is immediately exercisable, and
             has a term of ten years, subject to earlier termination,
             following the director's cessation of service on the Board of
             Directors. Any shares purchased upon exercise of the option
             are subject to repurchase should the director's service as a
             non-employee director cease prior to vesting of the shares.
             The initial automatic option grant of 16,666 shares vests in
             successive equal, annual installments over the director's
             initial four-year period of Board service. Each annual
             automatic option grant vests upon the director's completion of
             one year of service on the Board of Directors, as measured
             from the grant date. Each outstanding option vests
             immediately, however, upon certain changes in the ownership or
             control of Neose.

What are the committees of our Board of Directors?

         The Board of Directors has a Compensation Committee and an Audit
Committee.

         o   The Compensation Committee consists of Dr. Hamilton, Mr. MacMaster,
             and Dr. Rosenwald, each of whom is a non-employee director.
             The Compensation Committee determines the compensation of the
             Chief Executive Officer and the President, and reviews and
             takes action on the recommendation of the Chief Executive
             Officer as to the appropriate compensation of other officers.
             The Compensation Committee is primarily responsible for the
             administration of our Amended and Restated 1995 Stock
             Option/Stock Issuance Plan, under which option grants and
             stock issuances may be made to all employees, including
             executive officers, as well as non-employee directors and
             consultants. There are no compensation committee interlocks
             between our company and other entity involving our company's
             or such other entity's executive officers or board members.
         o   The Audit Committee consists of Mr. Sears, Dr. Hamilton, and
             Mr. MacMaster, each of whom is a non-employee director. The Audit
             Committee reviews with our auditors the plan and results of
             their audit and the adequacy of our systems of internal
             accounting controls and management information systems. In
             addition, the Audit Committee reviews the independence of the
             auditors and their fees for services rendered to Neose.

How many Board and Committee Meetings were held during 2000?

         During 2000, the Board of Directors held 6 meetings, the Audit
Committee held 3 meetings, and the Compensation Committee held one meeting. Each
director attended at least 75% of the meetings of the Board of Directors, and
all of his appropriate committee meeting(s).


                                       8





                           Summary Compensation Table


         The following table provides information about all compensation earned
in 2000, 1999, and 1998 by our Chief Executive Officer and other three executive
officers.




                                                                                     Long-term
                                                                                    Compensation
                                                   Annual Compensation                 Shares
                                                   -------------------               Underlying            All Other
Name and Principal Position              Year      Salary      Bonus                Options (#)        Compensation (1)
---------------------------              ----      ------      -----                -----------        ----------------

                                                                                               
Stephen A. Roth                          2000         $274,294        $109,718             50,000             $ 5,472(2)
   Chairman and Chief Executive          1999          263,744          65,936             30,000               5,432(2)
     Officer                             1998          253,600          63,400             60,000               5,432(2)

P. Sherrill Neff                         2000          268,237         107,295             50,000               5,472(3)
   President, Chief Operating            1999          257,920          64,480             30,000               5,432(3)
     Officer, and Chief Financial        1998          248,000          62,000             60,000               5,432(3)
     Officer

Edward J. McGuire                        2000          166,400          33,280             15,000               4,629(4)
   Vice President, Research and          1999          160,000          32,000             12,500               4,632(4)
     Development                         1998          150,000          30,000             15,000               4,235(4)

David A. Zopf                            2000          180,303          54,091             25,000               4,962(5)
   Vice President, New Product           1999          173,368          34,674             12,500               4,966(5)
     Development                         1998          166,700          33,340             15,000               4,635(5)



(1)      Includes $432 in each of 2000, 1999, and 1998 in premiums paid by us
         for group term life insurance.
(2)      Includes $5,040, $5,000, and $5,000 of matching contributions in 2000,
         1999, and 1998, respectively, to Dr. Roth's account in our 401(k) plan.
(3)      Includes $5,040, $5,000, and $5,000 of matching contributions in 2000,
         1999, and 1998, respectively, to Mr. Neff's account in our 401(k) plan.
(4)      Includes $4,197, $4,200, and $3,803 of matching contributions in 2000,
         1999, and 1998, respectively, to Dr. McGuire's account in our 401(k)
         Plan.
(5)      Includes $4,530, $4,534, and $4,203 of matching contributions in 2000,
         1999, and 1998, respectively, to Dr. Zopf's account in our 401(k) Plan.

                              Employment Agreements

         In December 1994, we entered into an employment agreement for an
initial period of three years (with automatic one-year extensions) with P.
Sherrill Neff, our President, Chief Operating Officer, and Chief Financial
Officer. Under this agreement, which includes our standard non-competition and
confidentiality agreement:

         o   Mr. Neff is to receive a minimum base salary of $225,000 per year,
             and a performance incentive bonus of up to 50% of base salary at
             the discretion of the Compensation Committee;
         o   The Board of Directors granted Mr. Neff options, which are now
             fully vested, to purchase 100,000 shares of common stock at an
             exercise price of $5.70 per share; and
         o   We are required to continue to pay Mr. Neff for the shorter of
             12 months after termination or the amount of time remaining in
             his employment term if Mr. Neff is:

                                       9





         o   Involuntarily terminated without cause (as defined in the
             agreement); or
         o   Terminated voluntarily or involuntarily following certain
             changes of control of Neose or a sale of all or
             substantially all of our assets in a complete liquidation
             or dissolution.

         In April 1992, we entered into a one-year employment agreement,
extendable in one-year increments, with David A. Zopf, our Vice President, New
Product Development. The agreement has been extended through March 31, 2002. The
agreement currently provides for an annual base salary of $180,303 and a bonus
of up to 25% of base salary at the discretion of the Chief Executive Officer. In
connection with the original agreement, the Board of Directors granted Dr. Zopf
options, which are now fully vested, to purchase 26,666 shares of common stock
at the fair market value on the date of grant. The agreement contains certain
restrictive covenants, including provisions relating to non-competition,
non-solicitation, and the non-disclosure of proprietary information during his
employment with Neose and for specified periods thereafter.

                               Option Grant Table

         The following table provides information about grants of stock options
made during 2000 to each of the executive officers named in our Summary
Compensation Table.





                                                Individual Grants
                          -----------------------------------------------------------------      Potential Realizable Value
                              Number of                                                          at Assumed Annual Rates of
                                Shares          Percentage of                                   Stock Price Appreciation for
                              Underlying        Total Options                                        Option Term (2)
                               Options           Granted to        Exercise   Expiration        ----------------------------
Name                         Granted (1)          Employees         Price        Date               5%               10%
----                         -----------          ---------         ------     --------         -----------      -----------

                                                                                          
Stephen A. Roth....            50,000               9.2%            $28.75     12/21/10         $ 904,036      $ 2,291,005

P. Sherrill Neff...            50,000               9.2              28.75     12/21/10           904,036        2,291,005

Edward J. McGuire..            15,000               2.8              28.75     12/21/10           271,211          687,301

David A. Zopf......            25,000               4.6              28.75     12/21/10           452,018        1,145,502


------------
(1)      Each option has a term of ten years from the date of grant and vests
         ratably over a four-year period, beginning on the first anniversary
         of the date of grant.
(2)      The potential realizable value of each grant is calculated assuming
         that the market price per share of common stock appreciates at
         annualized rates of 5% and 10% over the ten-year option term. The
         results of these calculations are based on rates set forth by the
         Securities and Exchange Commission and are not intended to forecast
         possible future appreciation of the price of our common stock.

                                       10





                    Aggregated Fiscal Year-End Option Values

         The following table provides information about the exercise of stock
options during 2000 and the value of stock options unexercised at the end of
2000 for the executive officers named in our Summary Compensation Table. The
value of unexercised stock options is calculated by multiplying the number of
option shares by the differences between the option exercise price and the
year-end stock price.



                                                                   Number of Shares
                             Number of                         Underlying Unexercised          Values of Unexercised
                               Shares                                 Options                   In-The-Money Options
                            Acquired On       Value         ----------------------------    ----------------------------
      Name                    Exercise      Realized        Exercisable    Unexercisable    Exercisable    Unexercisable
---------------------         --------      --------        -----------    -------------    -----------    -------------
                                                                                         
Stephen A. Roth.....              --       $     --           293,333        125,000        $5,398,264     $1,397,500
P. Sherrill Neff....              --             --           385,000        125,000         7,865,150      1,397,500
Edward J. McGuire...          19,000        541,263            65,875         35,625         1,521,669        460,781
David A. Zopf.......           7,552        148,088            65,240         45,625         1,525,457        503,281



The following Report of the Compensation Committee, Common Stock Performance
Graph, and Report of the Audit Committee shall not be deemed incorporated by
reference into any previous or subsequent filing with the Securities and
Exchange Commission, except to the extent that we specifically incorporate them
by reference in any such document.

                      Report of the Compensation Committee


What is our compensation philosophy?

         Our philosophy is to provide competitive compensation levels and, where
appropriate, align compensation of senior management with the long-term
interests of our stockholders. We determine the compensation of the senior
management team by evaluating our corporate performance, as well as each
executive officer's own level of performance.

What is the structure of our executive compensation?

         The elements of our executive compensation programs are:

         o   Base salary;
         o   Annual cash bonuses; and
         o   Annual long-term stock-based incentives.

         We have structured our compensation plan to provide incentives for
senior management performance that promote continuing improvements in our
corporate performance and stock price over both the short- and long-term.

How do we determine base salaries?

         We determine base salaries by each individual's experience and personal
performance, and by comparisons to similar positions within the biotechnology
industry. Base salaries are reviewed annually based on the criteria mentioned
above. The 2000 base salaries for our executive officers were approximately 4%
higher than their 1999 base salaries.

How do we determine annual bonuses?

         We base the amount of the award to each executive officer on a
combination of our overall performance and the individual's performance. The
Compensation Committee approved bonuses in 2000 to our executive officers
totaling $304,384, which was approximately $107,294, or 54%, higher than bonuses
approved by the Compensation Committee to our executive officers in 1999. The
Compensation Committee considered our corporate performance and each
individual's contributions to our success in determining the bonus amounts.

                                       11



How is compensation used to ensure senior management is focused on long-term
results?

         We use stock options to provide long-term incentives to our executive
officers. The Compensation Committee approves all grants of stock options to
executive officers. These stock option grants are designed to align the
interests of each executive officer with those of our other stockholders. Each
option is exercisable over a ten-year period at the market price on the date of
grant. Each option becomes exercisable in installments over a four-year vesting
period. The option will provide a benefit to the executive officer only if he or
she remains employed by Neose during the vesting period, and then only if the
market price of our common stock increases. Excluding the options granted to
Eric L. Sichel in connection with his joining Neose, the Compensation Committee
approved grants of options during 2000 to executive officers to purchase 140,000
shares of common stock, which were 55,000, or 65%, more option shares than were
granted by the Compensation Committee to executive officers during 1999. We
based the number of shares granted to each executive officer on a combination of
our overall performance and the individual's performance, as well as the size of
option grants made to executive officers of comparable biotechnology companies.

How do we determine the compensation of our Chief Executive Officer?

         Dr. Roth was our Chief Executive Officer during 2000. His compensation
is determined by establishing a base salary competitive with those paid by other
biotechnology companies, and making a significant percentage of his total
compensation package contingent upon corporate and individual performance. The
Compensation Committee set Dr. Roth's base salary at $274,294 for 2000. His 2000
bonus of $109,718 was based on the Compensation Committee's assessment of Dr.
Roth's individual performance and his contribution to our corporate performance.
The Compensation Committee granted Dr. Roth options in 2000 to purchase 50,000
shares of common stock. The grant was designed to provide Dr. Roth with a
continuing incentive to remain with Neose and contribute to our corporate
success.

What is the impact of Internal Revenue Code Section 162(m)?

         Under Section 162(m) of the Internal Revenue Code, we will not be
allowed a federal income tax deduction for compensation paid to certain
executive officers, to the extent that compensation exceeds $1 million per
executive officer in any one year. Compensation that qualifies as
performance-based compensation is not taken into account for purposes of the
limitation. The definition of performance-based compensation includes
compensation deemed paid in connection with the exercise of certain stock
options. The exercised stock options must have an exercise price equal to the
fair market value of the option shares on the grant date to qualify as
performance-based compensation. Our Amended and Restated 1995 Stock Option/Stock
Issuance Plan is intended to assure that the exercise of such stock options will
qualify as performance-based compensation.

         Because it is unlikely that the cash compensation payable to any of our
executive officers will soon approach the $1 million limit, the Compensation
Committee has decided not to take any other action to limit or restructure the
elements of cash compensation payable to our executive officers. The
Compensation Committee will reconsider this decision should the individual
compensation of any executive officer ever approach the $1 million level.

Compensation Committee of the Board of Directors

William F. Hamilton, Chairman
Douglas J. MacMaster, Jr.
Lindsay A. Rosenwald

                                       12






                         Common Stock Performance Graph

         The following graph assumes $100 was invested on February 16, 1996, the
date of our initial public offering, in our common stock. The graph compares the
cumulative return, which includes the reinvestment of dividends, of this
investment with an equivalent investment on that date in the Nasdaq Stock Market
- U.S. Index (the "Nasdaq Composite") or the Nasdaq Stock Market Biotech Index
(the "Nasdaq Biotech Index").


                               [GRAPHIC OMITTED]

--------------------------------------------------------------------------------
                       Ntec                   Nasdaq                 Biotech
--------------------------------------------------------------------------------

    02/16/1996         100                      100                     100
    12/31/1996         144                   118.37                   91.11
    12/31/1997         122                   143.98                   93.05
    12/31/1998       112.5                   201.03                  134.25
    12/31/1999         115                   373.09                  272.85
    12/31/2000         264                   226.51                  335.58
--------------------------------------------------------------------------------



                          Report of the Audit Committee

         Management is responsible for the financial reporting process,
including the system of internal control, and for the preparation of
consolidated financial statements in accordance with generally accepted
accounting principles. The Company's independent auditors are responsible for
auditing those financial statements. Our responsibility is to monitor and review
these processes. We are not professionally engaged in the practice of accounting
or auditing, however, and are not experts in the fields of accounting or
auditing, including with respect to auditor independence. We rely, without
independent verification, on the information provided to us and on the
representations made by management and the independent auditors. A copy of the
Charter of the Audit Committee is appended as Appendix A to this Proxy
Statement.

                                       13





         The Audit Committee has reviewed and discussed the audited financial
statements of the Company with the auditors, with and without management
present. The Audit Committee has discussed with the independent auditors, Arthur
Andersen LLP, the matters required to be discussed by Statement on Auditing
Standards No. 61, Communication with Audit Committees, as amended, by the
Auditing Standards Board of the American Institute of Certified Public
Accountants. The Audit Committee has also received and reviewed the written
disclosures and the letter from Arthur Andersen LLP required by Independence
Standards Board Statement No. 1, Independence Discussions with Audit Committees,
as amended, and has discussed with Arthur Andersen LLP their independence.

         Based on the reviews and discussions referred to above, we recommend to
the Board that the financial statements referred to above be included in the
Company's Annual Report on Form 10-K for the year ended December 31, 2000.

Audit Committee of the Board of Directors

Lowell E. Sears, Chairman
William F. Hamilton
Douglas J. MacMaster, Jr.


             Section 16(a) Beneficial Ownership Reporting Compliance

         Based solely upon a review of reports of stock ownership (and changes
in stock ownership) and written representation received by us, we believe that
our directors and executive officers met all of their filing requirements under
Section 16(a) of the Securities and Exchange Act of 1934 during the year ended
December 31, 2000, except that Eric L. Sichel, an executive officer of the
Company, failed to report in a timely fashion his ownership of 4,000 shares on
November 28, 2000, the date he became an executive officer of Neose.


                                       14





              Stock Ownership of our Directors, Executive Officers,
                            and 5% Beneficial Owners

         The following table shows information, as of April 23, 2001, about the
beneficial ownership (as defined under the regulations of the Securities and
Exchange Commission) of our common stock by:

         o   Each person we know to be the beneficial owner of at least five
             percent of our common stock;
         o   Each director (all of whom are nominees for re-election);
         o   Each executive officer named in our Summary Compensation Table; and
         o   All directors and executive officers as a group.

         As of April 23, 2001, there were 14,013,793 shares of our common stock
outstanding. To calculate a shareholder's percentage of beneficial ownership, we
must include in the numerator and denominator those shares underlying options
that a person has the right to acquire upon the exercise of stock options within
60 days of April 23, 2001. Options held by other shareholders, however, are
disregarded in this calculation. Therefore, the denominator used in calculating
beneficial ownership among our shareholders may differ. Unless we have indicated
otherwise, each person named in the table below has sole voting power and
investment power for the shares listed opposite such person's name.

                                                    Number of Shares
                                                    of Common Stock   Percent of
                                                      Beneficially      Shares
Name of Beneficial Owner                                 Owned       Outstanding
------------------------                            ---------------- -----------
Kopp Investment Advisors, Inc. (1)
7701 France Avenue South
Suite 500
Edina, MN 55455....................................    2,096,350          15.0%

Larry N. Feinberg (2)
c/o Oracle Partners
712 Fifth Avenue
45th Floor
New York, NY 10019.................................      886,400           6.3%

Emerald Advisors, Inc. (3)
1703 Oregon Pike
Lancaster, PA  17601...............................      697,439           5.0%

Directors and Executive Officers

Lindsay A. Rosenwald, M.D. (4)(5)
       c/o Paramount Capital, Inc.
       787 7th Avenue
       New York, NY 10019..........................    1,190,873           8.5%

Mark H. Rachesky, M.D. (4)(6)
       c/o MHR Fund Management LLC
       40 West 57th Street, 33rd Floor
       New York, NY  10019.........................      761,308           5.4%

Stephen A. Roth, Ph.D. (4)(7)......................      507,224           3.5%

P. Sherrill Neff (4)(8)............................      401,724           2.8%
Edward J. McGuire, Ph.D. (4)(9)....................      147,251           1.0%
William F. Hamilton, Ph.D. (4).....................      104,215            *
Douglas J. MacMaster, Jr. (4)......................       84,966            *
Lowell E. Sears (4)(10)............................       62,622            *
David A. Zopf, M.D. (4)............................       66,007            *
Jerry A. Weisbach, Ph.D. (4)(11)...................       54,216            *
All current directors and executive officers as
      a group (10 persons) (4).....................    3,380,406          22.5%

-----------------------
* Less than one percent.

                                       15



(1)  According to a Schedule 13G filed January 30, 2001, Kopp Investment
     Advisors, Inc. (KIA) is an investment adviser registered under the
     Investment Advisers Act of 1940. It is wholly owned by Kopp Holding Company
     (KHC), which is wholly owned by Mr. Leroy C. Kopp. Kopp Emerging Growth
     Fund (KEGF) is a registered investment company that has an investment
     advisor agreement with KIA. KIA reported sole voting power over 854,500
     shares, sole dispositive power over 712,000 shares and shared dispositive
     power over 1,384,350 shares. KHC reported beneficial ownership of 2,096,350
     shares. Mr. Kopp reported beneficial ownership of 2,161,350 shares of which
     Mr. Kopp reported sole voting power over 65,000 shares and sole dispositive
     power over 65,000 shares. KEGF reported beneficial ownership of 750,000
     shares. Of the shares beneficially owned by KIA, KHC, and Mr. Kopp,
     2,084,350 are held in a fiduciary or representative capacity.
(2)  In a Schedule 13G filed February 13, 2001, Mr. Feinberg reported that these
     shares of common stock are held directly and indirectly by Oracle Partners,
     L.P. ("Oracle Partners") (511,600 shares), Oracle Institutional Partners,
     L.P. ("Oracle Institutional") (113,600 shares), Oracle Associates, LLC
     ("Oracle Associates") (625,200 shares), Oracle Investment Management, Inc.
     (the "Investment Manager") (223,700 shares), and Mr. Feinberg (27,500
     shares). Oracle Investment Management, Inc. serves as investment manager to
     and has investment discretion over the securities held by several entities.
     Oracle Associates serves as the general partner of Oracle Partners and
     Oracle Institutional. Mr. Feinberg is senior managing member of Oracle
     Associates and the sole shareholder and president of the Investment
     Manager.
(3)  According to a Schedule 13G filed February 5, 2001, Emerald Advisors, Inc.
     owns and has sole dispositive power for 697,439 shares of common stock. Of
     these, Emerald Advisors has sole voting power for 545,294 shares.
(4)  Includes the following shares of common stock issuable under stock options
     that are exercisable within 60 days of April 23, 2001: Rosenwald - 21,313
     shares; Rachesky - 5,918 shares; Roth - 293,333 shares; Neff - 385,000
     shares; McGuire - 65,875 shares; Hamilton - 64,131 shares; MacMaster -
     49,132 shares; Sears - 41,298 shares; Zopf - 65,240 shares; Weisbach -
     49,132 shares; and all directors and executive officers as a group -
     1,040,372 shares.
(5)  Includes (i) 75,624 shares of common stock owned by Dr. Rosenwald's wife;
     (ii) 30,250 shares of common stock held by Dr. Rosenwald's wife as
     custodian for Dr. Rosenwald's children; (iii) 357,694 shares of common
     stock held by The Aries Master Fund; (iv) 167,133 shares of common stock
     held by the Aries Domestic Fund, L.P.; (v) 37,942 shares of common stock
     held by the Aries Domestic Fund II, L.P.; and (vi) 32,000 shares of common
     stock held by The Rosenwald Foundation, Inc. Paramount Capital Asset
     Management, Inc., of which Dr. Rosenwald is the sole shareholder, serves as
     the investment manager to The Aries Master Fund and also is the General
     Partner of the Aries Domestic Fund, and the Aries Domestic Fund II. Dr.
     Rosenwald disclaims beneficial ownership of the shares held by The Aries
     Master Fund, the Aries Domestic Fund, and the Aries Domestic Fund II,
     except to the extent of his pecuniary interest in the funds. Dr. Rosenwald
     may be deemed to have voting and investment control with respect to the
     shares held by The Aries Master Fund, the Aries Domestic Fund, and the
     Aries Domestic Fund II. In addition, Dr. Rosenwald disclaims beneficial
     ownership of the shares held by The Rosenwald Foundation. Dr. Rosenwald may
     be deemed to share voting and investment power with respect to the shares
     held by The Rosenwald Foundation.
(6)  Includes (i) 210,526 shares of common stock held by MHR Capital Partners
     LP, (ii) 502,759 shares of common stock held by MRL Partners LP, and (iii)
     42,105 shares of common stock held by OTT LLC. Dr. Rachesky is the managing
     member of MHR Advisors LLC, which is the General Partner of MHR Capital
     Partners and MRL Partners. Dr. Rachesky is the managing member of OTT LLC.
     Dr. Rachesky may be deemed to have voting and investment control over the
     shares held by MHR Capital Partners, MRL Partners, and OTT LLC. Dr.
     Rachesky disclaims beneficial ownership of the shares held by MHR Capital
     Partners, MRL Partners, and OTT LLC, except to the extent of his pecuniary
     interest in the funds.
(7)  Includes 100,000 shares of common stock owned by Dr. Roth's wife and 15,758
     shares of common stock owned by Dr. Roth's daughter. Dr. Roth disclaims
     beneficial ownership of the shares held by his wife and daughter.
(8)  Includes 1,000 shares of common stock owned by Mr. Neff's wife. Mr. Neff
     disclaims beneficial ownership of the shares held by his wife.
(9)  Includes 20,000 shares of common stock held by Dr. McGuire's wife. Dr.
     McGuire disclaims beneficial ownership of the shares held by his wife.
(10) Includes 21,324 shares of common stock owned by the Sears Family Living
     Trust, of which Mr. Sears is trustee.
(11) Includes 3,000 shares of common stock held by Dr. Weisbach's children as
     custodian for his grandchildren. Dr. Weisbach disclaims beneficial
     ownership of the shares held by his children.

                 Certain Relationships and Related Transaction

         On November 13, 2000, we amended the Amended and Restated Rights
Agreement between Neose and American Stock Transfer & Trust Company, as Rights
Agent. The amendment permits Kopp Investment Advisors to increase its percentage
of beneficial ownership in Neose to more than 15%, but less than 20%, without
being deemed an "Acquiring Person" under the Amended and Restated Rights
Agreement. We understand that Kopp Investment Advisors purchases and holds
these shares in the ordinary course of business solely for investment purposes
and not for the purpose, or with the effect, of changing or influencing the
control of Neose.

                                       16





         Proposal 2 -- Amendment to our Amended and Restated 1995 Stock
                           Option/Stock Issuance Plan

Proposed Amendment

         At the Annual Meeting, a proposal will be presented to the stockholders
to approve and adopt an amendment to our Amended and Restated 1995 Stock
Option/Stock Issuance Plan to increase by 700,000 shares the number of shares of
common stock authorized under the stock option plan. Of the 3,271,664 shares
currently authorized under the stock option plan, 510,831 shares have been
issued pursuant to option exercises and, therefore, are no longer available for
grant. Of the remaining 2,760,833 shares available for grant under the stock
option plan as of April 23, 2001, options to purchase 2,501,741 shares of common
stock were outstanding, and options to purchase 259,092 shares remained
available for future grants.

         In March 2001, the Board adopted the amendment, subject to approval by
our stockholders. We believe that our ability to grant options under the stock
option plan is a valuable and necessary compensation tool that aligns the
long-term financial interests of employees and directors with the financial
interests of our stockholders. In addition, we believe that the stock option
plan helps us to attract, retain, and motivate qualified employees, and
encourages them to devote their best efforts to our business and financial
success. An increase in the number of shares available for issuance under the
stock option plan is necessary to meet the above objectives. The Board of
Directors believes that approval of Proposal 2 is in the best interests of Neose
and its stockholders.

         The material features of the stock option plan are described below.
Approval of the proposal to amend the Amended and Restated 1995 Stock
Option/Stock Issuance Plan requires the affirmative vote of the holders of a
majority of shares present in person or represented by proxy at the Annual
Meeting.

         The Board of Directors recommends a vote "FOR" the proposal to amend
the stock option plan.

Description of the Stock Option Plan

         We adopted the stock option plan in 1995, and most recently amended the
stock option plan on June 26, 2000. The stock option plan, which designates our
Compensation Committee as the plan administrator, incorporates our two
predecessor stock option plans, the 1991 Stock Option Plan and the 1992 Stock
Option Plan. The stock option plan is divided into four separate components:

                                       17




         o    The Discretionary Option Grant Program, under which employees,
              non-employee directors (other than the members of the Compensation
              Committee), and consultants may be granted options to purchase
              shares of common stock;
         o    The Stock Issuance Program, under which employees, non-employee
              directors (other than the members of the Compensation Committee),
              and consultants may be issued shares of common stock either
              through the purchase of shares or as a bonus tied to the
              performance of services;
         o    The Automatic Option Grant Program, under which option grants will
              automatically be made annually to eligible non-employee directors
              to purchase shares of common stock; and
         o    The Director Fee Option Grant Program, under which non-employee
              directors may elect to apply all, or part, of their annual
              retainer fees otherwise payable in cash to the acquisition of a
              special option grant.

         As of April 23, 2001, options to purchase 2,501,741 shares of common
stock were outstanding under the stock option plan, and options to purchase
259,092 shares remained available for future grants. Shares of common stock
issued or currently issuable under the stock option plan are covered by
registration statements on Form S-8, which were filed with the Securities and
Exchange Commission on February 15, 1996, September 10, 1997, October 13, 1999,
and October 11, 2000.

     Eligibility

         All employees, non-employee directors, and consultants are eligible to
receive grants under the stock option plan. Non-employee directors are eligible
to receive grants pursuant to the Automatic Option Grant Program and the
Director Fee Option Grant Program, and non-employee directors who do not serve
on the Compensation Committee are eligible to participate in the Discretionary
Option Grant Program and the Stock Issuance Program. As of April 23, 2001, there
were approximately 101 employees and 6 non-employee directors eligible to
participate in the stock option plan. No person may be granted, in any given
year, more than 50% of the total number of shares for which stock options, stock
appreciation rights, and direct stock issuances may be granted over the term of
the stock option plan.

     Discretionary Option Grant Program

         Under the Discretionary Option Grant Program, the Compensation
Committee has complete discretion to determine:

     o    Which eligible individuals are to receive option grants or stock
          appreciation rights;
     o    The time or times when option grants are to be made;
     o    The number of shares subject to, and the vesting schedule for, each
          option grant;
     o    The designation of each stock option as either an incentive or a
          non-qualified stock option;
     o    The maximum term for which each option grant is to remain outstanding,
          which term, for an incentive stock option, may not exceed ten years,
          and for a stock option granted to a person who owns more than 10% of
          the voting power of Neose may not exceed five years; and
     o    The option exercise price, which for a non-qualified stock option may
          not be less than 85% of the fair market value of the stock on the date
          of grant. The exercise price of an incentive stock option must have an
          exercise price of at least 100% of the fair market value on the date
          of grant, provided that the recipient of the option grant does not own
          more than 10% of the voting power of Neose. If the recipient of an
          incentive stock option owns more than 10% of the voting power of
          Neose, the exercise price must be at least 110% of the fair market
          value on the date of grant. The Internal Revenue Code allows an
          optionee to receive incentive stock options only to the extent that
          the aggregate amount of incentive stock options exercisable for the
          first time by an optionee during any calendar year does not exceed
          $100,000. Any stock option that is granted to an optionee who fails to
          meet the criteria for an incentive stock option must be granted as a
          non-qualified stock option.

                                       18




         The fair market value of the common stock is the closing sale price per
share on the grant date as such price is reported on The Nasdaq Stock Market. If
there is no reported closing sale price on such date, the fair market value is
the closing sale price on the last preceding date for which a quotation exists.
The closing sale price per share of common stock on April 23, 2001 was $24.99.

         The Compensation Committee also has the authority to cancel outstanding
options under the Discretionary Option Grant Program (including options
incorporated from our two predecessor stock option plans) in return for the
grant of new options for the same or different number of option shares, with an
exercise price per share based upon the fair market value of the common stock on
the new grant date.

         Stock appreciation rights may be issued under the Discretionary Option
Grant Program. These stock appreciation rights will allow the holders to
surrender their outstanding options for an appreciation distribution from Neose
equal to the fair market value of the vested shares of common stock subject to
the surrendered option less the aggregate exercise price payable for such
shares. The appreciation distribution may be made in cash or in shares of common
stock.

     Stock Issuance Program

         Under the Stock Issuance Program, the Compensation Committee has
complete discretion to determine:

     o   Which eligible individuals are to receive stock issuances;
     o   The time or times when stock issuances are to be made; and
     o   The number of shares subject to, and the vesting schedule for, each
         stock issuance.

         The Compensation Committee may issue shares of common stock for cash, a
promissory note, or past services rendered. The consideration must be equal in
value to at least 85% of the fair market value of the common stock issued. The
issued shares may be fully and immediately vested, vest in one or more
installments over a period of service, or vest upon the attainment of certain
performance milestones determined by the Compensation Committee.

     Automatic Option Grant Program

         Under the Automatic Option Grant Program, each non-employee director,
on the date first elected or appointed to the Board of Directors, will
automatically be granted an option to purchase 16,666 shares of common stock,
provided such individual has not been previously employed by us. In addition,
upon each annual re-election to the Board, each non-employee director with at
least six months of Board service will automatically be granted an option to
purchase 10,000 shares of common stock.

         All grants under the Automatic Option Grant Program will be made in
strict compliance with the provisions of such programs. Accordingly, the
Compensation Committee does not exercise any administrative discretion with
respect to these automatic options. Each automatic option has a term of ten
years, subject to earlier termination following the director's cessation of
service on the Board. Each automatic option is immediately exercisable. Any
shares purchased upon exercise of the option, however, are subject to repurchase

                                       19




if the director's service as a non-employee director ceases prior to vesting of
the shares. The initial automatic option grant to purchase 16,666 shares will
vest in successive equal, annual installments over the director's initial
four-year period of Board service. Each additional automatic option grant vests
upon the director's completion of one year of service on the Board of Directors,
as measured from the grant date. In addition, each outstanding option will vest
immediately upon certain changes in the ownership or control of Neose.

     Director Fee Option Grant Program

         Under the Director Fee Option Grant Program, each non-employee director
may elect to apply all, or part, of his or her annual retainer fee otherwise
payable in cash to the acquisition of a special option grant under the Director
Fee Option Grant Program. Elections to acquire an option grant in lieu of annual
retainer fees must be filed with us prior to the start of the calendar year of
participation. If an election is filed, the option grant is automatically made
on the first trading day in January, and has an exercise price per share equal
to one-third of the fair market value of the common stock on the grant date. The
number of option shares is determined by dividing the amount of the retainer fee
applied to the program by two-thirds of the fair market value of common stock on
the grant date. As a result, the total spread on the option (the fair market
value of the option shares on the grant date less the aggregate exercise price
payable for those shares) is equal to the portion of the retainer fee subject to
the director's election.

         All grants under the Director Fee Option Grant Program will be made in
strict compliance with the provisions of such programs. Accordingly, the
Compensation Committee does not exercise any administrative discretion with
respect to these options. The option becomes exercisable in a series of twelve
successive equal, monthly installments upon the director's completion of each
month of Board service during the calendar year for which the option grant is
made. The option remains exercisable for such shares until the earlier of the
expiration of the ten-year option term or the end of the three-year period
measured from the date of the director's cessation of Board service. In
addition, upon certain changes in the ownership or control of Neose, each
outstanding option will immediately vest in full.

     Corporate Transactions

         If we are a party to certain corporate transactions (as defined in the
stock option plan), including certain mergers or asset sales, each outstanding
option and unvested stock issuance will, under certain circumstances,
automatically vest in full. Options and stock issuances that do not vest in full
at the time of the acquisition will vest in full if the individual's service is
terminated, whether involuntarily or through a resignation for good reason,
within 18 months following the acquisition. The Compensation Committee may also
accelerate the vesting of options and unvested stock issuances upon a change in
control (as defined in the stock option plan) of Neose or the termination of the
individual's service, whether involuntarily or through a resignation for good
reason, within a specified period following the change in control. Options
currently outstanding under our predecessor stock option plans contain different
provisions for acceleration of vesting in connection with an acquisition of
Neose. Options outstanding under the 1992 Stock Option Plan may, under certain
circumstances, vest in full upon a change in control. Options outstanding under
the 1991 Stock Option Plan do not contain any acceleration of vesting provisions
in connection with a change in control. The Compensation Committee has the
discretion, however, to extend the acceleration of vesting provisions of the
stock option plan to outstanding options under our predecessor stock option
plans.

                                       20




     Amendment and Termination of the Stock Option Plan

         The Board has complete and exclusive power and authority to amend or
modify the stock option plan in any, or all, respects. No amendment, however,
may adversely affect the rights and obligations of options outstanding at the
time under the stock option plan. In addition, no amendment may adversely affect
the rights of any optionee with respect to common stock issued under the stock
option plan prior to such action, unless the optionee consents to such action.
In addition, the Board may not, without stockholder approval, amend the stock
option plan to:

     o   Increase the maximum number of shares issuable under the stock
         option plan, or the maximum amount of shares for which any one
         individual participating in the stock option plan may be granted
         stock options, stock appreciation rights, and direct stock
         issuances for any given year;
     o   Materially modify the eligibility requirements for participation; or
     o   Otherwise materially increase the benefits accruing to participants.

         The stock option plan will terminate on the earlier of February 28,
2005 or the date on which all shares available for issuance under the stock
option plan have been issued.

Federal income tax consequences of the stock option plan

         The following discussion summarizes the principal federal income tax
consequences of the stock option plan based on the Internal Revenue Code and its
regulations, and administrative and judicial interpretations. The summary does
not address any foreign, state, or local tax consequences of participation in
the stock option plan.

     Non-Qualified Stock Options

         There generally are no federal income tax consequences to an optionee
or to Neose upon the grant of a non-qualified stock option. Upon the exercise of
a non-qualified stock option, an optionee will recognize ordinary compensation
income in an amount equal to the fair market value of the shares at the time of
exercise less the exercise price of the non-qualified stock option. We generally
will be entitled to a corresponding federal income tax deduction. Upon the sale
of shares of common stock that were acquired by the exercise of a non-qualified
stock option, an optionee will recognize a capital gain or loss. The amount of
the capital gain or loss will be equal to the difference between the amount
realized upon the sale of the shares and the optionee's adjusted tax basis in
the shares of common stock. The optionee's adjusted tax basis in the shares of
common stock is equal to the exercise price plus the amount of ordinary income
recognized by the optionee at the time of exercise of the non-qualified stock
option. The tax rate for the capital gain will depend on the length of time the
shares were held by the optionee and other factors.

     Incentive Stock Options

         A recipient of an incentive stock option will not recognize taxable
income, for purposes of the regular income tax, upon either the grant or
exercise of the incentive stock option. Under the regulations of the Internal
Revenue Code governing the alternative minimum tax, however, the exercise of an
incentive stock option generally increases the recipient's alternative minimum
taxable income in the year in which an incentive stock option is exercised. The
amount of the increase is equal to the fair market value of the shares of common
stock acquired upon exercise less the stock option exercise price. Upon a
qualifying disposition of shares acquired upon exercise of an incentive stock
option, an optionee will recognize long-term capital gain or loss, and we will
not be entitled to a corresponding federal income tax deduction. For these
purposes, a qualifying disposition is defined as a disposition of shares at
least two years after the incentive stock option was granted and at least one
year after exercise of the incentive stock option. As a general rule, if an

                                       21




optionee disposes of the shares acquired upon exercise of an incentive stock
option before satisfying both holding period requirements, the gain recognized
on such a disposition will be taxed to the optionee as ordinary income, and we
generally will be entitled to a corresponding federal income tax deduction. The
amount of ordinary income is the difference between the fair market value of the
shares on the date of exercise and the option exercise price. The gain, if any,
in excess of the amount recognized as ordinary income on such a disqualifying
disposition will be long-term or short-term capital gain, depending upon the
length of time the optionee held the shares prior to the disposition.

     Stock Appreciation Rights

         An optionee will not recognize any income upon the grant of a stock
appreciation right. Upon the exercise of a stock appreciation right, the
optionee will recognize ordinary compensation income in the amount of both the
cash and the fair market value of the shares of common stock received upon such
exercise, and we generally will be entitled to a corresponding federal income
tax deduction. When an optionee sells shares acquired upon the exercise of a
stock appreciation right, the optionee will recognize a capital gain or loss.
The amount of the capital gain or loss will be equal to the difference between
the amount realized on the sale and the amount of ordinary income recognized at
the time of exercise of the stock appreciation right.

     Stock Issuances

         A recipient generally will recognize taxable income upon the grant of a
stock issuance if:

         o  The shares are not subject to a substantial risk of forfeiture; and
         o  There are no restrictions on the transferability of the shares at
            the time of grant.

         A recipient of a grant of restricted stock (a stock issuance not
meeting either of the above criteria) normally will not recognize taxable income
upon the grant, and we will not be entitled to a corresponding federal income
tax deduction. When the shares either are transferable or are no longer subject
to a substantial risk of forfeiture, the recipient will recognize ordinary
compensation income, and we generally will be entitled to a corresponding
federal income tax deduction. The amount of the ordinary compensation income
will be equal to the difference between the fair market value of the common
stock at that time and any amount paid for the shares. A recipient may, however,
elect to recognize ordinary compensation income in the year the restricted stock
grant is awarded, and we generally will be entitled to a corresponding federal
income tax deduction. The amount of ordinary compensation income will be equal
to the difference between the fair market value of the common stock at that time
and any amount paid for the shares.

     Payment of Withholding Taxes

         Our obligation to deliver shares of common stock upon the exercise of
any stock option or upon the issuance of any shares is subject to the
satisfaction of all applicable income and employment tax withholding
requirements. In some circumstances, we permit an optionee to remit directly to
the appropriate taxing authority the amount of the optionee's withholding tax
obligations.

Plan benefits

         Option grants to our current executive officers and directors to
purchase the following number of shares of common stock have been made under the
stock option plan (including our two predecessor stock option plans) from
adoption of the 1991 Stock Option Plan through April 23, 2001: Stephen A.
Roth--418,333; P. Sherrill Neff--510,000; Edward J. McGuire--122,500; Eric L.
Sichel--125,000; David A. Zopf--115,832; current executive officers as a
group--1,291,665; current non-employee directors as a group--305,543; and all
other employees and consultants as a group--1,709,534.

                                       22




         The benefits and amounts that may be received in the future by persons
eligible to participate in the stock option plan are not currently determinable,
except as to those future automatic grants to be awarded to non-employee
directors under the Automatic Option Grant Program.

                    Independent Certified Public Accountants

         Arthur Andersen LLP has served as our independent certified public
accountants since 1994. Arthur Andersen LLP has been selected to continue as our
independent certified public accountants for the current year. A representative
of the firm is expected to be present at the Annual Meeting, will have the
opportunity to make a statement if he or she desires to do so, and will be
available to respond to appropriate questions. The following additional
information is provided as required by the Securities and Exchange Commission.

     o   Audit Fees. The aggregate fees billed by Arthur Andersen LLP for
         professional services rendered to the Company for the 2000 audit and
         for review of the Company's financial statements included in the
         Company's Quarterly Reports on Form 10-Q for 2000 totaled approximately
         $41,000.
     o   Financial Information Systems Design and Implementation Fees. The
         Company did not engage Arthur Andersen LLP during 2000 to provide
         professional services with respect to financial information systems
         design and implementation as described in Paragraph (c)(4)(ii) of Rule
         2-01 of Regulation S-X.
     o   All Other Fees. The aggregate fees billed by Arthur Andersen LLP for
         all other services rendered during 2000, including tax related
         services, totaled approximately $71,000.

         The Audit Committee has considered whether the provision by Arthur
Andersen LLP of professional services not related to the audit of the financial
statements referred to above and not related to the reviews of the interim
financial statements referred to above is compatible with maintaining the
independence of Arthur Andersen LLP, and has determined it to be so.

              Requirements for Advance Notification of Nominations
                            and Stockholder Proposals

     Advance Notice Requirements for the next year's Annual Meeting

         Under Section 11 of Article II of our By-Laws, you may nominate a
person for election as a director or propose business to be considered at the
next year's Annual Meeting if you:

     o   Are a holder of record at the time of giving the notice described
         below;
     o   Are entitled to vote at the Annual Meeting; and

                                       23




     o   Deliver a written notice of intent to make a nomination or proposal to
         our Corporate Secretary at our offices. You must deliver the written
         notice of intent, which must contain the relevant information
         described below, between December 1, 2001 and December 31, 2001. If
         the date of next year's Annual Meeting is earlier than March 31, 2002
         or later than June 29, 2002, however, your written notice of intent
         must be delivered between the 90th day before next year's Annual
         Meeting and the later of:

         o    The 60th day before next year's Annual Meeting; or
         o    The 10th day after our first public announcement of next year's
              Annual Meeting date.

         If the Board of Directors decides to propose, for next year's Annual
Meeting, an increase in the number of directors, the advance notice requirements
will differ from those described above if we fail to make a timely public
announcement of the proposal. Our public announcement must be made as described
in our By-Laws, and must either name all of the nominees for director or specify
the new size of the Board of Directors. To be considered timely, our first
public announcement of such a proposal must be made:

     o   By April 11, 2002, if the date of next year's Annual Meeting is between
         March 31, 2002 and June 29, 2002; or
     o   By 70 days before next year's Annual Meeting, if the date of next
         year's Annual Meeting is earlier than March 31, 2002 or later than
         June 29, 2002.

         If we fail to meet the applicable deadline for making a timely public
announcement, and you would like to nominate individuals for the new position(s)
created by the increase, you must deliver your written notice of intent by no
later than the 10th day after our first public announcement. Your written notice
of intent may nominate individuals only for new position(s) created by the
increase, and must contain the information described below.

     Requirements for a Written Notice of Intent

         Your written notice of intent to make a nomination or proposal must
contain your name, address, and the number of each class of our shares you own
beneficially and of record. If you are delivering the written notice of intent
on behalf of a beneficial owner of our shares, the written notice of intent also
must contain the beneficial owner's name, address, and the number of each class
of our shares held beneficially and of record. Your written notice of intent
also must include:

     o   As to each person you propose to nominate for election or
         re-election as a director, the nominee's written consent to be
         named in the proxy statement as a nominee and to serve as a
         director if elected.

                                       24




     o   As to any other business you propose to bring before the meeting:

          -  A brief description of the business;
          -  The reasons for conducting the business at the meeting; and
          -  Your material interest in the business, or the material interest
             in the business of the beneficial owner, if any, on whose behalf
             the proposal is made.

     Other Requirements

         You also must comply with all applicable requirements of the Securities
Exchange Act of 1934 for nominations of directors and proposals of business to
be conducted at stockholder meetings. If you have not complied with the
procedures described above, the chairman of a meeting may refuse to acknowledge
your nomination or proposal. These procedures will not be deemed to affect any
of your rights under Rule 14a-8 under the Securities Exchange Act of 1934 to
request inclusion of proposals in our proxy statements.



                                       25





                                    EXHIBIT A

                      CHARTER OF THE AUDIT COMMITTEE OF THE
                 BOARD OF DIRECTORS OF NEOSE TECHNOLOGIES, INC.

The Audit Committee of the Company's Board of Directors shall be composed of
three or more directors who are "independent" as such term is defined in
applicable regulations of the NASD, and who are free of any relationship that,
in the opinion of the Board of Directors, would interfere with their exercise of
independent judgment as a committee member. Each of the members of the Audit
Committee shall be a person who through prior experience is financially
sophisticated and familiar with financial oversight responsibilities. The
independent auditors of the Company's financial statements shall be accountable
to the Audit Committee and to the Board of Directors of the Company. In carrying
out these responsibilities, the Audit Committee will:

   o   Meet not fewer than four times per year.
   o   Review and recommend to the Board of Directors the independent auditors
       to be selected to audit the financial statements of the Company and its
       divisions and subsidiaries and, when appropriate, recommend the
       replacement of the Company's auditors.
   o   Meet with the independent auditors and financial management of the
       Company to review the scope of the proposed audit for the current year
       and the audit procedures to be utilized, and at its conclusion to
       review such audit, including any comments or recommendations of the
       independent auditors. Any changes in accounting principles shall be
       reviewed.
   o   Review with the independent auditors and the Company's financial and
       accounting personnel the adequacy and effectiveness of the accounting
       and financial controls of the Company, and elicit any recommendations
       for the improvement of such internal control procedures or particular
       areas where new or more detailed controls or procedures are desirable.
       Particular emphasis shall be given to the adequacy of such internal
       controls to expose any payments, transactions, or procedures that might
       be deemed illegal or otherwise improper.
   o   Provide sufficient opportunity for independent auditors to meet with
       the members of the Audit Committee without members of management
       present. Among the items to be discussed in these meetings are the
       independent auditors' evaluation of the Company's financial,
       accounting, and auditing personnel, and the cooperation that the
       independent auditors received during the course of the audit.
   o   Oversee the independence of the independent auditors through
       appropriate means including obtaining a written statement delineating
       all relationships between the independent auditors and the Company and
       determining whether and to what extent the objectivity and independence
       of the auditors may be impacted by all relationships and services.
   o   Discuss with the independent auditors their qualitative judgments about
       the appropriateness, not just the acceptability, of accounting
       principles and financial disclosure practices used or proposed to be
       adopted by the Company, particularly about the degree of aggressiveness
       or conservatism of the Company's accounting principles and underlying
       estimates.
   o   Establish and review adherence to the Company's cash management and
       investment policies.
   o   Provide the report for the Company's annual proxy statement required by
       regulations of the Securities and Exchange Commission respecting
       activities of the Committee and state whether the Committee recommends
       inclusion of the Company's audited financial statements in the annual
       report to be filed with the Commission.
   o   Investigate any matter brought to its attention within the scope of its
       duties, with the power to retain outside counsel or other consultants
       for this purpose if, in its judgment, that is appropriate.
   o   Submit the minutes of all meetings of the Audit Committee to discuss
       the material matters discussed at each committee meeting with the Board
       of Directors.

                                       26





                            Neose Technologies, Inc.
            PROXY FOR ANNUAL MEETING OF STOCKHOLDERS - JUNE 20, 2001
       (This Proxy is solicited by the Board of Directors of the Company)


     The undersigned stockholder of Neose Technologies, Inc. hereby appoints
Stephen A. Roth, Chairman and Chief Executive Officer, and P. Sherrill Neff,
President, Chief Operating Officer, and Chief Financial Officer, and each of
them, with full power of substitution, proxies to vote the shares of stock that
the undersigned could vote if personally present at the Annual Meeting of
Stockholders of Neose Technologies, Inc. to be held at the Company's
headquarters at 102 Witmer Road, Horsham, PA 19044, on June 20, 2001, at
1:00 P.M. (Eastern Daylight Time), or any adjournment thereof.

                  (Continued and to be signed on Reverse Side)








                        Please date, sign and mail your
                      proxy card back as soon as possible:

                         Annual Meeting of Stockholders
                            NEOSE TECHNOLOGIES, INC.

                                  June 20, 2001

                Please Detach and Mail in the Envelope Provided
--------------------------------------------------------------------------------

A  [X]  Please mark your
        votes as in this
        example.

1. ELECTION       FOR all nominees          WITHHOLD
   OF             at right (except as       AUTHORITY
   DIRECTORS      marked to the             to vote for all
                  contrary below)           nominees at right
                       |_|                       |_|

INSTRUCTION: To withhold authority to vote for
an individual nominee, strike a line through
that nominee's name in the list at right.

                                           NOMINEES:  Stephen A. Roth
                                                      P. Sherrill Neff
                                                      William F. Hamilton
                                                      Douglas J. MacMaster, Jr.
                                                      Mark H. Rachesky
                                                      Lindsay A. Rosenwald
                                                      Lowell E. Sears
                                                      Jerry A. Weisbach

                                                  FOR      AGAINST     ABSTAIN
                                                  |_|       |_|          | |

2. PROPOSAL TO APPROVE AND ADOPT AN AMENDMENT
   TO THE NEOSE TECHNOLOGIES, INC. AMENDED
   AND RESTATED 1995 STOCK OPTIONS/STOCK
   ISSUANCE PLAN (the "Amended Plan") to
   increase by 700,000 shares the number of shares authorized for issuance under
   the Amended Plan.

3. IN THEIR DISCRETION UPON SUCH OTHER MATTERS AS MAY PROPERLY COME BEFORE
   THE MEETING

UNLESS OTHERWISE SPECIFIED, THIS PROXY WILL BE VOTED FOR THE ELECTION OF
DIRECTORS NAMED IN PROPOSAL 1 AND FOR PROPOSAL 2.

THE UNDERSIGNED HEREBY ACKNOWLEDGES RECEIPT OF THE NOTICE OF ANNUAL MEETING OF
STOCKHOLDERS AND THE RELATED PROXY STATEMENT.

Signature____________________________________         Dated:____________________


_____________________________________________         Dated:____________________
          SIGNATURE: IF HELD JOINTLY

Note: Please date and sign exactly as your name appears on the envelope in which
      this material was mailed. If shares are held jointly, each stockholder
      should sign. Executors, administrators, trustees, etc. should use full
      title, and if more than one, all should sign. If the stockholder is a
      corporation, please sign full corporate name by an authorized officer. If
      the stockholder is a partnership, please sign full partnership name by an
      authorized person.