Ownership Submission
FORM 5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
Form 3 Holdings Reported
Form 4 Transactions Reported
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

ANNUAL STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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1. Name and Address of Reporting Person *
Dobroff Lawrence
2. Issuer Name and Ticker or Trading Symbol
BIOSPECIFICS TECHNOLOGIES CORP [BSTC.PK]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
Chief Financial Officer
(Last)
(First)
(Middle)

15 SOUTHWICK COURT NORTH
3. Statement for Issuer's Fiscal Year Ended (Month/Day/Year)
12/31/2005
(Street)


PLAINVIEW, NY 11803
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Reporting
(check applicable line)

_X_ Form Filed by One Reporting Person
___ Form Filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned at end of Issuer's Fiscal Year
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Amount (A) or (D) Price

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number. SEC 2270 (9-02)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned at End of Issuer's Fiscal Year
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
(A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (Right to Buy) $ 1.45 01/06/2005   A4 1,272   01/06/2005 01/05/2015 Common Stock
1,272
$ 0 2,230
D
 
Stock Option (Right to Buy) $ 1.6 02/04/2005   A4 1,149   02/04/2005 02/03/2015 Common Stock
1,149
$ 0 3,379
D
 
Stock Option (Right to Buy) $ 1.6 03/04/2005   A4 1,149   03/04/2005 03/03/2015 Common Stock
1,149
$ 0 4,528
D
 
Stock Option (Right to Buy) $ 1.2 04/06/2005   A4 1,543   04/06/2005 04/05/2015 Common Stock
1,543
$ 0 6,071
D
 
Stock Option (Right to Buy) $ 1.2 05/06/2005   A4 1,543   05/06/2005 05/05/2015 Common Stock
1,543
$ 0 7,614
D
 
Stock Option (Right to Buy) $ 1.05 06/06/2005   A4 1,754   06/06/2005 06/05/2015 Common Stock
1,754
$ 0 9,368
D
 
Stock Option (Right to Buy) $ 1.08 07/06/2005   A4 1,701   07/06/2005 07/05/2015 Common Stock
1,701
$ 0 11,069
D
 
Stock Option (Right to Buy) $ 2 08/05/2005   A4 921   08/05/2005 08/04/2015 Common Stock
921
$ 0 11,990
D
 
Stock Option (Right to Buy) $ 1.7 09/06/2005   A4 1,082   09/06/2005 09/05/2015 Common Stock
1,082
$ 0 13,072
D
 
Stock Option (Right to Buy) $ 1.25 10/06/2005   A4 1,476   10/06/2005 10/05/2015 Common Stock
1,476
$ 0 14,548
D
 
Stock Option (Right to Buy) $ 0.8 11/04/2005   A4 2,315   11/04/2005 11/03/2015 Common Stock
2,315
$ 0 16,863
D
 
Stock Option (Right to Buy) $ 1.6 12/06/2005   A4 1,149   12/06/2005 12/05/2015 Common Stock
1,149
$ 0 18,012
D
 

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
Dobroff Lawrence
15 SOUTHWICK COURT NORTH
PLAINVIEW, NY 11803
      Chief Financial Officer  

Signatures

/s/ Lawrence Dobroff 02/13/2006
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note: File three copies of this Form, one of which must be manually signed. If space provided is insufficient, see Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.