Ownership Submission
FORM 5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
Form 3 Holdings Reported
Form 4 Transactions Reported
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

ANNUAL STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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1. Name and Address of Reporting Person *
Dobroff Lawrence
2. Issuer Name and Ticker or Trading Symbol
BIOSPECIFICS TECHNOLOGIES CORP [BSTC.PK]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
Chief Financial Officer
(Last)
(First)
(Middle)

15 SOUTHWICK COURT NORTH
3. Statement for Issuer's Fiscal Year Ended (Month/Day/Year)
12/31/2006
(Street)


PLAINVIEW, NY 11803
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Reporting
(check applicable line)

_X_ Form Filed by One Reporting Person
___ Form Filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned at end of Issuer's Fiscal Year
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Amount (A) or (D) Price

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number. SEC 2270 (9-02)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned at End of Issuer's Fiscal Year
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
(A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (Right to Buy) $ 0.97 01/06/2006   A4 1,894   01/06/2006 01/05/2016 Common Stock
1,894
$ 0 19,906
D
 
Stock Option (Right to Buy) $ 1 02/06/2006   A4 1,852   02/06/2006 02/05/2016 Common Stock
1,852
$ 0 46,758 (1)
D
 
Stock Option (Right to Buy) $ 0.85 03/06/2006   A4 2,165   03/06/2006 03/05/2016 Common Stock
2,165
$ 0 48,923
D
 
Stock Option (Right to Buy) $ 1.6 04/06/2006   A4 1,149   04/06/2006 04/05/2016 Common Stock
1,149
$ 0 50,072
D
 
Stock Option (Right to Buy) $ 1.05 05/05/2006   A4 1,754   05/05/2006 05/04/2016 Common Stock
1,754
$ 0 51,826
D
 
Stock Option (Right to Buy) $ 0.82 06/06/2006   A4 2,252   06/06/2006 06/05/2016 Common Stock
2,252
$ 0 54,078
D
 
Stock Option (Right to Buy) $ 1.1 07/06/2006   A4 1,684   07/06/2006 07/05/2016 Common Stock
1,684
$ 0 55,762
D
 
Stock Option (Right to Buy) $ 1 08/04/2006   A4 1,852   08/04/2006 08/03/2016 Common Stock
1,852
$ 0 57,614
D
 
Stock Option (Right to Buy) $ 0.83 09/06/2006   A4 2,222   09/06/2006 09/05/2016 Common Stock
2,222
$ 0 74,836 (2)
D
 
Stock Option (Right to Buy) $ 1.2 10/06/2006   A4 1,543   10/06/2006 10/05/2016 Common Stock
1,543
$ 0 76,379
D
 
Stock Option (Right to Buy) $ 2.9 11/06/2006   A4 636   11/06/2006 11/05/2016 Common Stock
636
$ 0 77,015
D
 
Stock Option (Right to Buy) $ 4.5 12/06/2006   A4 410   12/06/2006 12/05/2016 Common Stock
410
$ 0 77,425
D
 

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
Dobroff Lawrence
15 SOUTHWICK COURT NORTH
PLAINVIEW, NY 11803
      Chief Financial Officer  

Signatures

/s/ Lawrence Dobroff 02/13/2006
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Includes 25,000 stock options granted on January 23, 2006 and already reported on a Form 4 filed on March 28, 2006.
(2) Includes 15,000 stock options granted on September 6, 2006 and already reported on a Form 4 filed on September 12, 2006.

Note: File three copies of this Form, one of which must be manually signed. If space provided is insufficient, see Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.