Fecal calprotectin (FC) is a 36.5 kDa calcium-binding protein that accounts for 60% of neutrophil cytoplasmic proteins and is accumulated and activated at sites of intestinal inflammation and released into the feces.
FC has a variety of biological properties, including antibacterial, immunomodulatory, and antiproliferative activities. In particular, the presence of FC is quantitatively related to the migration of neutrophils into the gastrointestinal tract. Therefore, it is a useful marker of intestinal inflammation to determine the presence and severity of inflammation in the intestine.
It may only take four steps to develop from intestinal inflammation to cancer: intestinal inflammation -> intestinal polyps -> adenoma -> intestinal cancer. This process takes years or even decades, providing enough opportunities for early screening of intestinal diseases. However, because many people do not pay attention to early screening, many cases of bowel cancer are diagnosed at an advanced stage.
According to authoritative data at home and abroad, the 5-year survival rate of early-stage colorectal cancer can reach 90% to 95%. If it is carcinoma in situ (the earliest stage), the cure rate is close to 100%. The 5-year survival rate of late-stage colorectal cancer is less than 10%. These data strongly suggest that early screening is crucial to improving survival and cure rates for patients with bowel cancer. At present, some experts have proposed that ordinary people should undergo early screening for bowel cancer after the age of 40, and people with family history or other high-risk factors should undergo early screening.
Calprotectin detection reagent is a painless, non-invasive, easy-to-operate product used to evaluate the degree of intestinal inflammation and assist in the diagnosis of intestinal inflammation-related diseases (inflammatory bowel disease, adenoma, colorectal cancer). If the calprotectin test is negative, you don’t need to do a colonoscopy for the time being. If the test result is positive, don’t be too nervous. Most of the post-colonoscopy results are precancerous lesions such as adenomas. These lesions can be effectively managed through early intervention.
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