A new study from Ohio State University Wexner Medical Center has discovered why immunotherapy fails in 60-80% of cancer patients. Researchers identified a previously unknown stress pathway called TexPSR that floods weakened immune cells with misfolded proteins, crippling their ability to attack tumors. Blocking this pathway in laboratory models restored immune cell function and significantly improved immunotherapy effectiveness across multiple cancer types.
As companies like Calidi Biotherapeutics Inc. (NYSE American: CLDI) undertake R&D programs aimed at commercializing novel immunotherapies, the insights gained from the study on…
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