Registration No. 333-164039
Filed Pursuant to Rule 424(b)(3)



Arrowhead Research Corporation

Common Stock



Sticker Supplement to Resale Prospectus dated June 11, 2010

This sticker serves to supplement the Resale Prospectus dated June 11, 2010 to provide information with respect to a new selling shareholder who will receive shares pursuant to transfer and exercise of a warrant from F. Berdon & Co. L.P., a selling shareholder included in the Resale Prospectus, and to reduce the number of shares held by F. Berdon & Co. disclosed in the Resale Prospectus by the number of such shares issuable under the warrant.

Under the caption “Selling Security Holders” the following person should be added to the table and F. Berdon & Co L.P.’s shares as set forth in the table should be revised as follows:



   Shares Beneficially Owned 
Before Offering(1)
    Number of Shares 
Being Offered(1)
     Shares Beneficially Owned
After Offering(1)
     Number      Percent            Number      Percent  


     8,333                 8,333        —              

F. Berdon & Co, L.P.

     13,333                  13,333         —              


* Less than one percent
(1) All share amounts have been adjusted to reflect a 1-for-10 reverse split effected on November 17, 2011.

This sticker is part of the Resale Prospectus and must accompany the Resale Prospectus.



The date of this sticker is February 13, 2014.